signaling pathway - Ontology Report

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PATHWAY ONTOLOGY - ANNOTATIONS	{{ watchLinkText }}
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:	signaling pathway	go back to main search page
Accession:	PW:0000003	browse the term
Definition:	The pathways where a signal - hormone, neurotransmitter, growth factor, peptide, any molecule - triggers one or multiple cascades of events. This involves a number of molecules, including receptors, proteins, ligands, messengers, any participating molecule. A signaling pathway may be upstream or downstream of other signaling pathways. Signaling pathways control a very broad spectrum of processes as well as pathways.
Comment:	The definition was compiled based on a number of definitions available in various dictionaries.
Synonyms:	related_synonym:	Signal Transduction

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Rat (2646) Mouse (2512) Human (2505) Chinchilla (1890) Bonobo (1938) Dog (1936) Squirrel (1893) Pig (1929) Green Monkey (1930) Naked Mole-rat (1885) All
Genes (1936)

acetylcholine signaling pathway via muscarinic acetylcholine receptor

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

acetylcholinesterase

NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702

CHAT

choline O-acetyltransferase

NCBI chr28:1,480,364...1,528,858
Ensembl chr28:1,482,202...1,528,776

GRK2

G protein-coupled receptor kinase 2

NCBI chr18:50,148,566...50,167,422
Ensembl chr18:50,148,598...50,167,428

GRK5

G protein-coupled receptor kinase 5

NCBI chr28:29,424,350...29,636,552
Ensembl chr28:29,424,593...29,632,741

RGS2

regulator of G protein signaling 2

NCBI chr38:6,200,237...6,203,491
Ensembl chr38:6,200,657...6,203,494

RGS4

regulator of G protein signaling 4

NCBI chr38:19,771,454...19,778,917
Ensembl chr38:19,771,441...19,779,190

RGS6

regulator of G protein signaling 6

NCBI chr 8:45,392,246...45,975,073
Ensembl chr 8:45,438,239...46,009,049

SLC18A3

solute carrier family 18 member A3

NCBI chr28:1,476,873...1,478,538
Ensembl chr28:1,476,774...1,478,505

SLC5A7

solute carrier family 5 member 7

NCBI chr10:35,879,880...35,908,203
Ensembl chr10:35,883,245...35,908,569

acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CHRM2

cholinergic receptor muscarinic 2

NCBI chr16:11,515,727...11,665,651
Ensembl chr16:11,515,426...11,664,977

CHRM4

cholinergic receptor muscarinic 4

NCBI chr18:43,077,115...43,084,298
Ensembl chr18:43,082,404...43,083,840

GNAI1

G protein subunit alpha i1

NCBI chr18:19,924,381...19,952,956
Ensembl chr18:19,924,235...19,951,244

GNAI2

G protein subunit alpha i2

NCBI chr20:39,075,085...39,094,697
Ensembl chr20:39,075,085...39,094,697

acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CHRM1

cholinergic receptor muscarinic 1

NCBI chr18:53,783,938...53,797,750
Ensembl chr18:53,795,326...53,796,708

CHRM3

cholinergic receptor muscarinic 3

NCBI chr 4:504,663...999,550
Ensembl chr 4:506,990...520,613

CHRM5

cholinergic receptor muscarinic 5

NCBI chr30:988,764...1,074,599
Ensembl chr30:990,208...991,806

GNA11

G protein subunit alpha 11

G protein subunit alpha 14

NCBI chr 1:80,992,992...81,178,362
Ensembl chr 1:80,992,863...81,177,674

GNAQ

G protein subunit alpha q

NCBI chr 1:80,733,530...80,928,065
Ensembl chr 1:80,715,366...80,928,065

acetylcholine signaling pathway via nicotinic acetylcholine receptor

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

acetylcholinesterase

NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702

agrin

NCBI chr 5:56,239,621...56,273,679
Ensembl chr 5:56,239,701...56,272,745

CHAT

choline O-acetyltransferase

NCBI chr28:1,480,364...1,528,858
Ensembl chr28:1,482,202...1,528,776

CHRNA1

cholinergic receptor nicotinic alpha 1 subunit

ISO

RGD

PMID:19126755 PMID:23032192

RGD:8549508 RGD:8549510

NCBI chr36:18,726,243...18,742,505
Ensembl chr36:18,726,243...18,742,505

CHRNA10

cholinergic receptor nicotinic alpha 10 subunit

NCBI chr21:26,216,862...26,233,226

CHRNA2

cholinergic receptor nicotinic alpha 2 subunit

NCBI chr25:30,117,384...30,137,223
Ensembl chr25:30,117,239...30,135,599

CHRNA3

cholinergic receptor nicotinic alpha 3 subunit

NCBI chr13:38,330,287...38,343,142
Ensembl chr13:38,328,814...38,346,246

CHRNA4

cholinergic receptor nicotinic alpha 4 subunit

NCBI chr24:47,024,948...47,036,507
Ensembl chr24:47,025,187...47,042,266

CHRNA5

cholinergic receptor nicotinic alpha 5 subunit

NCBI chr13:38,343,966...38,355,534
Ensembl chr13:38,346,104...38,355,468

CHRNA6

cholinergic receptor nicotinic alpha 6 subunit

NCBI chr16:22,990,377...23,009,257
Ensembl chr16:22,990,167...23,009,106

CHRNA7

cholinergic receptor nicotinic alpha 7 subunit

NCBI chr 3:36,852,082...37,164,930
Ensembl chr 3:36,852,543...36,978,399

CHRNA9

cholinergic receptor nicotinic alpha 9 subunit

NCBI chr 3:72,190,431...72,204,092
Ensembl chr 3:72,190,555...72,203,404

CHRNB1

cholinergic receptor nicotinic beta 1 subunit

ISO

RGD

PMID:19126755 PMID:23032192

RGD:8549508 RGD:8549510

NCBI chr 5:32,375,152...32,383,517
Ensembl chr 5:32,375,215...32,382,929

CHRNB2

cholinergic receptor nicotinic beta 2 subunit

NCBI chr 7:42,786,505...42,797,976
Ensembl chr 7:42,789,600...42,795,722

CHRNB3

cholinergic receptor nicotinic beta 3 subunit

NCBI chr16:23,021,652...23,040,907
Ensembl chr16:23,021,645...23,048,347

CHRNB4

cholinergic receptor nicotinic beta 4 subunit

NCBI chr13:38,312,537...38,327,242
Ensembl chr13:38,312,173...38,328,341

CHRND

cholinergic receptor nicotinic delta subunit

ISO

RGD

PMID:19126755 PMID:23032192

RGD:8549508 RGD:8549510

NCBI chr25:44,166,089...44,175,047
Ensembl chr25:44,165,819...44,174,216

CHRNE

cholinergic receptor nicotinic epsilon subunit

ISO

RGD

PMID:19126755 PMID:23032192

RGD:8549508 RGD:8549510

NCBI chr 5:31,696,710...31,707,639
Ensembl chr 5:31,696,993...31,708,671

CHRNG

cholinergic receptor nicotinic gamma subunit

ISO

RGD

PMID:19126755 PMID:23032192

RGD:8549508 RGD:8549510

NCBI chr25:44,178,149...44,183,623
Ensembl chr25:44,178,181...44,183,626

docking protein 7

NCBI chr 3:60,873,298...60,897,047
Ensembl chr 3:60,869,206...60,897,318

LRP4

LDL receptor related protein 4

NCBI chr18:42,616,683...42,667,297
Ensembl chr18:42,616,426...42,665,794

MUSK

muscle associated receptor tyrosine kinase

NCBI chr11:65,552,320...65,642,165
Ensembl chr11:65,551,889...65,642,349

RAPSN

receptor associated protein of the synapse

NCBI chr18:42,199,160...42,210,668
Ensembl chr18:42,199,412...42,210,673

SLC18A3

solute carrier family 18 member A3

NCBI chr28:1,476,873...1,478,538
Ensembl chr28:1,476,774...1,478,505

SLC5A7

solute carrier family 5 member 7

NCBI chr10:35,879,880...35,908,203
Ensembl chr10:35,883,245...35,908,569

activin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACVR1

activin A receptor type 1

ISO

PID
RGD

PMID:12770730

PID:200029 RGD:1559169

NCBI chr36:3,743,257...3,818,659
Ensembl chr36:3,744,163...3,818,652

ACVR1B

activin A receptor type 1B

NCBI chr27:3,009,710...3,029,726
Ensembl chr27:2,994,857...3,042,396

ACVR2A

activin A receptor type 2A

NCBI chr19:49,642,429...49,726,720
Ensembl chr19:49,641,219...49,723,420

ACVR2B

activin A receptor type 2B

NCBI chr23:8,211,555...8,225,596
Ensembl chr23:8,192,483...8,218,894

ACVRL1

activin A receptor like type 1

ISO

PID
RGD

PMID:12770730

PID:200029 RGD:1559169

NCBI chr27:3,075,373...3,090,549
Ensembl chr27:3,076,124...3,092,469

FKBP1A

FKBP prolyl isomerase 1A

ISO

PID

PID:200029

NCBI chr24:19,618,581...19,643,685
Ensembl chr24:19,618,558...19,643,046

SMAD family member 2

NCBI chr 7:43,696,883...43,778,063
Ensembl chr 7:43,700,445...43,769,983

SMAD family member 3

NCBI chr30:31,246,313...31,360,098
Ensembl chr30:31,245,657...31,363,337

adenosine monophosphate-activated protein kinase (AMPK) signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CAB39

calcium binding protein 39

ISO

RGD

PMID:14511394 PMID:15509864

RGD:1600678 RGD:1600691

NCBI chr25:42,752,798...42,801,257
Ensembl chr25:42,703,332...42,799,279

calmodulin 1

NCBI chr 8:61,398,231...61,408,874
Ensembl chr 8:61,398,244...61,406,195

calmodulin 2

NCBI chr10:49,299,698...49,314,533
Ensembl chr10:49,299,897...49,314,457

calmodulin 3

NCBI chr 1:109,284,729...109,294,491
Ensembl chr 1:109,286,155...109,294,391

CAMKK1

calcium/calmodulin dependent protein kinase kinase 1

NCBI chr 9:47,643,781...47,670,536
Ensembl chr 9:47,645,815...47,663,855

CAMKK2

calcium/calmodulin dependent protein kinase kinase 2

NCBI chr26:7,848,191...7,895,317
Ensembl chr26:7,847,466...7,893,410

CPT1A

carnitine palmitoyltransferase 1A

NCBI chr18:49,136,691...49,190,117
Ensembl chr18:49,136,691...49,190,117

PPM1E

protein phosphatase, Mg2+/Mn2+ dependent 1E

NCBI chr 9:33,350,379...33,560,523
Ensembl chr 9:33,350,614...33,560,272

PPM1F

protein phosphatase, Mg2+/Mn2+ dependent 1F

NCBI chr26:31,162,810...31,193,586
Ensembl chr26:31,166,593...31,193,587

PPP1CA

protein phosphatase 1 catalytic subunit alpha

NCBI chr18:50,062,352...50,065,166
Ensembl chr18:50,062,352...50,065,166

PPP1CB

protein phosphatase 1 catalytic subunit beta

NCBI chr17:22,680,691...22,699,999
Ensembl chr17:22,679,783...22,699,999

PPP1R3D

protein phosphatase 1 regulatory subunit 3D

NCBI chr24:44,550,028...44,551,556
Ensembl chr24:44,550,320...44,551,219

PPP2CA

protein phosphatase 2 catalytic subunit alpha

NCBI chr11:22,388,327...22,410,052
Ensembl chr11:22,385,257...22,410,052

PRKAA1

protein kinase AMP-activated catalytic subunit alpha 1

ISO

RGD

PMID:12829246 PMID:14511394 PMID:15509864

RGD:1600678 RGD:1600679 RGD:1600691

NCBI chr 4:68,579,061...68,614,548
Ensembl chr 4:68,579,037...68,611,841

PRKAA2

protein kinase AMP-activated catalytic subunit alpha 2

ISO

RGD

PMID:12829246 PMID:14511394 PMID:15509864

RGD:1600678 RGD:1600679 RGD:1600691

NCBI chr 5:52,809,792...52,855,072
Ensembl chr 5:52,815,609...52,876,609

PRKAB1

protein kinase AMP-activated non-catalytic subunit beta 1

ISO

RGD

PMID:12829246 PMID:15509864

RGD:1600678 RGD:1600679

NCBI chr26:15,706,583...15,716,612
Ensembl chr26:15,706,678...15,715,314

PRKAB2

protein kinase AMP-activated non-catalytic subunit beta 2

ISO

RGD

PMID:12829246 PMID:15509864

RGD:1600678 RGD:1600679

NCBI chr17:57,614,499...57,630,041
Ensembl chr17:57,616,451...57,630,041

PRKAG1

protein kinase AMP-activated non-catalytic subunit gamma 1

ISO

RGD

PMID:12829246 PMID:14511394 PMID:15509864

RGD:1600678 RGD:1600679 RGD:1600691

NCBI chr27:5,556,433...5,570,675
Ensembl chr27:5,556,549...5,570,235

PRKAG2

protein kinase AMP-activated non-catalytic subunit gamma 2

ISO

RGD

PMID:12829246 PMID:15509864

RGD:1600678 RGD:1600679

NCBI chr16:15,521,304...15,786,237
Ensembl chr16:15,522,111...15,785,854

PRKAG3

protein kinase AMP-activated non-catalytic subunit gamma 3

ISO

RGD

PMID:12829246 PMID:15509864

RGD:1600678 RGD:1600679

NCBI chr37:25,405,794...25,414,745
Ensembl chr37:25,406,190...25,414,961

STK11

serine/threonine kinase 11

ISO

RGD

PMID:14511394 PMID:15509864

RGD:1600678 RGD:1600691

NCBI chr20:57,558,966...57,579,163
Ensembl chr20:57,559,424...57,579,118

STRADA

STE20 related adaptor alpha

ISO

RGD

PMID:14511394 PMID:15509864

RGD:1600678 RGD:1600691

NCBI chr 9:11,684,905...11,712,515
Ensembl chr 9:11,684,663...11,712,432

TSC1

TSC complex subunit 1

NCBI chr 9:51,409,307...51,459,546
Ensembl chr 9:51,425,937...51,454,677

adenosine signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ADCY2

adenylate cyclase 2

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr34:6,139,931...6,527,677
Ensembl chr34:6,140,276...6,527,677

ADORA2A

adenosine A2a receptor

ISO

SMPDB

SMP:00320

NCBI chr26:28,141,076...28,150,600
Ensembl chr26:28,141,076...28,150,598

ADORA2B

adenosine A2b receptor

ISO

SMPDB

SMP:00321

NCBI chr 5:39,884,375...39,908,214

AKT1

AKT serine/threonine kinase 1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193

ARHGEF7

Rho guanine nucleotide exchange factor 7

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr22:59,207,278...59,305,240
Ensembl chr22:59,206,868...59,303,049

ATF2

activating transcription factor 2

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr36:19,032,376...19,103,382
Ensembl chr36:19,010,717...19,103,292

BAD

BCL2 associated agonist of cell death

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr18:52,781,335...52,791,789
Ensembl chr18:52,781,921...52,791,405

BRAF

B-Raf proto-oncogene, serine/threonine kinase

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr16:8,222,909...8,318,179
Ensembl chr16:8,222,907...8,317,906

CHUK

component of inhibitor of nuclear factor kappa B kinase complex

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr28:12,964,670...13,001,557
Ensembl chr28:12,965,479...13,001,512

CREB1

cAMP responsive element binding protein 1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr37:15,921,214...15,978,492
Ensembl chr37:15,939,138...15,977,556

ELK1

ETS transcription factor ELK1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr X:41,256,205...41,270,656
Ensembl chr X:41,257,482...41,270,776

GNAS

GNAS complex locus

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr24:43,643,409...43,658,641
Ensembl chr24:43,643,405...43,658,657

GNB1

G protein subunit beta 1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 5:56,777,854...56,879,619
Ensembl chr 5:56,779,354...56,817,295

GNG12

G protein subunit gamma 12

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 6:77,316,649...77,378,356
Ensembl chr 6:77,338,685...77,374,937

HRAS

HRas proto-oncogene, GTPase

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr18:25,642,844...25,644,717
Ensembl chr18:25,642,844...25,644,717

IKBKB

inhibitor of nuclear factor kappa B kinase subunit beta

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr16:23,359,551...23,419,114
Ensembl chr16:23,359,813...23,419,075

JUN

Jun proto-oncogene, AP-1 transcription factor subunit

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 5:50,966,698...50,968,939

LOC403934

cell division cycle 42

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 2:77,153,276...77,169,947
Ensembl chr 2:77,153,095...77,199,211

MAP2K2

mitogen-activated protein kinase kinase 2

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr20:55,465,460...55,487,629
Ensembl chr20:55,465,212...55,487,641

MAP2K6

mitogen-activated protein kinase kinase 6

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 9:15,840,714...15,962,400
Ensembl chr 9:15,840,983...15,952,026

MAP2K7

mitogen-activated protein kinase kinase 7

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr20:52,594,450...52,604,236
Ensembl chr20:52,594,536...52,602,150

MAP3K1

mitogen-activated protein kinase kinase kinase 1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 2:43,918,210...43,996,817
Ensembl chr 2:43,917,604...43,995,209

MAP3K4

mitogen-activated protein kinase kinase kinase 4

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 1:49,590,615...49,702,289
Ensembl chr 1:49,548,274...49,702,289

MAPK1

mitogen-activated protein kinase 1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998

MAPK11

mitogen-activated protein kinase 11

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr10:16,977,133...16,984,764

MAPK8

mitogen-activated protein kinase 8

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401

NFKB1

nuclear factor kappa B subunit 1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr32:23,948,598...24,040,704
Ensembl chr32:23,942,954...24,040,703

NFKB2

nuclear factor kappa B subunit 2

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr28:14,902,212...14,910,437
Ensembl chr28:14,902,706...14,910,395

NFKBIA

NFKB inhibitor alpha

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 8:14,100,203...14,103,453
Ensembl chr 8:14,100,671...14,103,433

PAK1

p21 (RAC1) activated kinase 1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr21:21,341,530...21,409,535
Ensembl chr21:21,265,484...21,408,416

PARD6A

par-6 family cell polarity regulator alpha

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 5:81,787,424...81,789,833
Ensembl chr 5:81,787,553...81,790,324

PDPK1

3-phosphoinositide dependent protein kinase 1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 6:38,426,464...38,506,520
Ensembl chr 6:38,431,600...38,499,295

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910

PRKACB

protein kinase cAMP-activated catalytic subunit beta

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 6:63,615,445...63,729,386
Ensembl chr 6:63,618,323...63,730,146

PRKCZ

protein kinase C zeta

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664

RAP1A

RAP1A, member of RAS oncogene family

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr17:63,725,812...63,795,359
Ensembl chr17:63,726,248...63,746,881

RAPGEF2

Rap guanine nucleotide exchange factor 2

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr15:56,133,094...56,353,609
Ensembl chr15:56,174,578...56,352,569

RAPGEF3

Rap guanine nucleotide exchange factor 3

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr27:6,993,452...7,030,372
Ensembl chr27:6,993,452...7,017,316

RPS6KA1

ribosomal protein S6 kinase A1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 2:73,497,128...73,533,853
Ensembl chr 2:73,497,473...73,534,378

adiponectin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ADIPOQ

adiponectin, C1Q and collagen domain containing

NCBI chr34:19,398,310...19,410,519
Ensembl chr34:19,354,825...19,409,844

ADIPOR1

adiponectin receptor 1

NCBI chr 7:240,035...254,287
Ensembl chr 7:240,065...282,845

ADIPOR2

adiponectin receptor 2

ISO

RGD

PMID:16823476 PMID:18755807 PMID:24797033 PMID:27220557

RGD:1642395 RGD:25824939 RGD:25824940 RGD:25824943

NCBI chr27:43,739,269...43,840,116
Ensembl chr27:43,741,679...43,878,467

aldosterone signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CASP8AP2

caspase 8 associated protein 2

NCBI chr12:49,040,069...49,077,418
Ensembl chr12:49,039,411...49,077,688

CREB binding protein

NCBI chr 6:37,410,201...37,536,688
Ensembl chr 6:37,409,930...37,534,176

DAXX

death domain associated protein

NCBI chr12:2,755,960...2,760,687
Ensembl chr12:2,755,960...2,761,340

DExH-box helicase 9

NCBI chr 7:16,233,763...16,292,576
Ensembl chr 7:16,233,814...16,292,618

ELL

elongation factor for RNA polymerase II

NCBI chr20:44,512,665...44,592,156
Ensembl chr20:44,489,219...44,598,497

FAF1

Fas associated factor 1

NCBI chr15:10,232,520...10,691,106
Ensembl chr15:10,232,614...10,690,741

FKBP4

FKBP prolyl isomerase 4

NCBI chr27:41,950,087...41,959,136
Ensembl chr27:41,950,509...41,959,034

FKBP5

FKBP prolyl isomerase 5

NCBI chr12:4,724,668...4,833,691
Ensembl chr12:4,727,497...4,833,323

HSP90AA1

heat shock protein 90 alpha family class A member 1

NCBI chr 8:70,091,203...70,096,107
Ensembl chr 8:70,092,217...70,095,243

HSP90AB1

heat shock protein 90 alpha family class B member 1

NCBI chr12:12,658,415...12,664,945
Ensembl chr12:12,660,008...12,664,940

Janus kinase 2

NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997

NCOA1

nuclear receptor coactivator 1

NCBI chr17:18,880,676...19,124,300
Ensembl chr17:18,880,383...19,122,258

NCOA2

nuclear receptor coactivator 2

NCBI chr29:19,253,849...19,471,640
Ensembl chr29:19,222,842...19,545,371

NCOR1

nuclear receptor corepressor 1

NCBI chr 5:39,687,530...39,837,003
Ensembl chr 5:39,687,543...39,836,464

NCOR2

nuclear receptor corepressor 2

NCBI chr26:5,352,670...5,493,741
Ensembl chr26:5,331,459...5,493,830

NFYC

nuclear transcription factor Y subunit gamma

NCBI chr15:2,268,050...2,334,939
Ensembl chr15:2,268,102...2,318,605

NR3C2

nuclear receptor subfamily 3 group C member 2

NCBI chr15:46,390,030...46,718,000
Ensembl chr15:46,390,023...46,710,131

PIAS1

protein inhibitor of activated STAT 1

NCBI chr30:32,116,363...32,232,530
Ensembl chr30:32,119,311...32,228,945

PPARGC1A

PPARG coactivator 1 alpha

NCBI chr 3:85,645,942...86,284,570
Ensembl chr 3:86,016,140...86,281,269

PTGES3

prostaglandin E synthase 3

NCBI chr10:885,744...903,814
Ensembl chr10:870,392...909,161

UBE2I

ubiquitin conjugating enzyme E2 I

NCBI chr 6:39,440,123...39,453,688
Ensembl chr 6:39,440,314...39,817,588

altered androgen signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

androgen receptor

ISO

RGD

PMID:18008377 PMID:23759327

RGD:2326139 RGD:8693397

NCBI chr24:34,713,390...34,731,461
NCBI chr X:51,969,785...52,167,450
Ensembl chr X:51,969,785...52,151,912

NCOA2

nuclear receptor coactivator 2

NCBI chr29:19,253,849...19,471,640
Ensembl chr29:19,222,842...19,545,371

NCOR2

nuclear receptor corepressor 2

NCBI chr26:5,352,670...5,493,741
Ensembl chr26:5,331,459...5,493,830

altered clathrin-dependent synaptic vesicle endocytosis

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

DNAJC6

DnaJ heat shock protein family (Hsp40) member C6

NCBI chr 5:44,882,111...45,021,152
Ensembl chr 5:44,884,283...45,120,203

synaptojanin 1

NCBI chr31:27,308,169...27,399,226
Ensembl chr31:27,308,169...27,399,197

altered epidermal growth factor/neuregulin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

EGF

epidermal growth factor

NCBI chr32:30,073,541...30,166,904
Ensembl chr32:30,073,950...30,166,295

EGFR

epidermal growth factor receptor

ISO

RGD

PMID:19506583 PMID:20519133 PMID:20951313

RGD:5133241 RGD:5133242 RGD:5490965

NCBI chr18:5,983,669...6,044,092
Ensembl chr18:5,982,770...6,042,631

ERBB2

erb-b2 receptor tyrosine kinase 2

ISO

RGD

PMID:19078924 PMID:21277552

RGD:4143515 RGD:5133243

NCBI chr 9:22,760,373...22,785,367
Ensembl chr 9:22,759,256...22,785,294

TGFA

transforming growth factor alpha

NCBI chr10:68,915,671...68,957,027

altered Erk5 MAPK signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

MAP2K5

mitogen-activated protein kinase kinase 5

NCBI chr30:31,665,032...31,920,792
Ensembl chr30:31,664,564...31,920,751

MAPK7

mitogen-activated protein kinase 7

NCBI chr 5:40,831,949...40,836,990
Ensembl chr 5:40,831,947...40,836,505

altered extracellular signal-regulated Raf/Mek/Erk signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BRAF

B-Raf proto-oncogene, serine/threonine kinase

ISO

RGD

PMID:17126425 PMID:18098337 PMID:20951313 PMID:21277552

RGD:2293882 RGD:2298531 RGD:5133242 RGD:5133243

NCBI chr16:8,222,909...8,318,179
Ensembl chr16:8,222,907...8,317,906

KRAS

KRAS proto-oncogene, GTPase

ISO

RGD

PMID:16112461 PMID:18772397 PMID:19078924 PMID:19506583 PMID:20951313

RGD:2306732 RGD:4143515 RGD:5133242 RGD:5490965 RGD:5490966

NCBI chr27:22,261,753...22,296,704
Ensembl chr27:22,257,941...22,293,369

MAP2K1

mitogen-activated protein kinase kinase 1

ISO

RGD

PMID:20951313 PMID:21277552

RGD:5133242 RGD:5133243

NCBI chr30:30,683,192...30,760,479
Ensembl chr30:30,683,107...30,760,479

RAF1

Raf-1 proto-oncogene, serine/threonine kinase

NCBI chr20:5,892,839...5,972,672
Ensembl chr20:5,892,834...5,972,090

altered Hedgehog signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BOC

BOC cell adhesion associated, oncogene regulated

NCBI chr33:17,508,046...17,629,705
Ensembl chr33:17,556,910...17,630,259

DHH

desert hedgehog signaling molecule

NCBI chr27:5,490,122...5,497,144
Ensembl chr27:5,490,441...5,494,636

GLI1

GLI family zinc finger 1

ISO

RGD

PMID:18772397 PMID:21186299

RGD:5490966 RGD:5491005

NCBI chr10:1,565,306...1,575,971
Ensembl chr10:1,565,244...1,575,982

GLI3

GLI family zinc finger 3

NCBI chr18:7,800,817...8,071,531
Ensembl chr18:7,801,394...8,068,132

LRP2

LDL receptor related protein 2

NCBI chr36:13,910,450...14,107,081
Ensembl chr36:13,911,865...14,107,546

SHH

sonic hedgehog signaling molecule

NCBI chr16:18,650,553...18,663,571
Ensembl chr16:18,484,809...18,662,903

SMO

smoothened, frizzled class receptor

NCBI chr14:7,518,871...7,527,703
Ensembl chr14:7,518,856...7,528,033

altered hypoxia inducible factor pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

VHL

von Hippel-Lindau tumor suppressor

NCBI chr20:8,206,616...8,211,347
Ensembl chr20:8,206,616...8,211,323

altered insulin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

insulin

NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122

insulin receptor

NCBI chr20:52,017,261...52,136,061
Ensembl chr20:52,021,887...52,136,046

altered insulin-like growth factor signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

IGF1

insulin like growth factor 1

NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794

altered integrin mediated signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ILK

integrin linked kinase

NCBI chr21:29,911,326...29,917,972
Ensembl chr21:29,911,364...29,917,974

ITGA1

integrin subunit alpha 1

NCBI chr 4:62,287,823...62,455,940
Ensembl chr 4:62,293,082...62,455,650

ITGA11

integrin subunit alpha 11

NCBI chr30:32,322,441...32,405,679
Ensembl chr30:32,323,687...32,405,661

ITGA4

integrin subunit alpha 4

ISO

RGD

PMID:11782963 PMID:18772397

RGD:1302879 RGD:5490966

NCBI chr36:24,670,464...24,686,719
Ensembl chr36:24,653,408...24,729,057

ITGA8

integrin subunit alpha 8

NCBI chr 2:21,034,630...21,244,304
Ensembl chr 2:21,075,653...21,241,951

ITGA9

integrin subunit alpha 9

NCBI chr23:7,285,118...7,618,056
Ensembl chr23:7,281,378...7,613,899

altered Jak-Stat signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Janus kinase 2

NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997

Janus kinase 3

NCBI chr20:45,051,135...45,068,445
Ensembl chr20:45,050,526...45,072,805

altered leptin system pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

INSR

insulin receptor

ISO

increased basal hypothalamic leptin signaling without changes in leptin receptor expression after antisense-mediated hypothalamus-specific Insr knock-down

RGD

PMID:17585961

RGD:2290473

NCBI chr20:52,017,261...52,136,061
Ensembl chr20:52,021,887...52,136,046

LEP

leptin

ISO

RGD

PMID:11102451 PMID:15703762

RGD:1357910 RGD:61790

NCBI chr14:8,115,396...8,130,946
Ensembl chr14:8,116,122...8,131,395

LEPR

leptin receptor

ISO

RGD

PMID:11102451 PMID:15703762 PMID:17229951

RGD:1357910 RGD:1600611 RGD:61790

NCBI chr 5:44,684,118...44,775,626
Ensembl chr 5:44,688,109...44,775,636

altered melanocortin system pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AGRP

agouti related neuropeptide

NCBI chr 5:81,924,249...81,926,510
Ensembl chr 5:81,925,055...81,925,845

MC4R

melanocortin 4 receptor

NCBI chr 1:16,131,829...16,132,827
Ensembl chr 1:16,131,589...16,133,079

PCSK1

proprotein convertase subtilisin/kexin type 1

ISO

RGD

PMID:11874690 PMID:15189116

RGD:1357925 RGD:1357926

NCBI chr 3:13,233,342...13,276,921
Ensembl chr 3:13,233,594...13,274,094

POMC

proopiomelanocortin

ISO

RGD

PMID:11874690 PMID:15189116

RGD:1357925 RGD:1357926

NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440

syndecan 1

NCBI chr17:15,220,906...15,243,974
Ensembl chr17:15,222,094...15,243,890

altered Notch signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

HEY1

hes related family bHLH transcription factor with YRPW motif 1

NCBI chr29:27,185,191...27,188,121
Ensembl chr29:27,185,191...27,188,121

NUMB

NUMB endocytic adaptor protein

NCBI chr 8:46,620,444...46,781,564
Ensembl chr 8:46,607,556...46,782,175

altered Notch signaling pathway involving promoters

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

HEY1

hes related family bHLH transcription factor with YRPW motif 1

NCBI chr29:27,185,191...27,188,121
Ensembl chr29:27,185,191...27,188,121

altered Notch signaling pathway involving the macromolecules modifying the main players

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

NUMB

NUMB endocytic adaptor protein

NCBI chr 8:46,620,444...46,781,564
Ensembl chr 8:46,607,556...46,782,175

PSEN2

presenilin 2

ISO

C. elegans transgenics expressing wild-type and mutant PSEN2

RGD

PMID:16474849

RGD:2302525

NCBI chr 7:38,147,157...38,163,023
Ensembl chr 7:38,147,173...38,166,722

altered Notch signaling pathway involving the main players

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

DLL3

delta like canonical Notch ligand 3

ISO

Mutations in the gene have been associated with Spondylocostal dysostosis

RGD

PMID:12141422

RGD:1304493

NCBI chr 1:113,737,662...113,745,936

JAG1

jagged canonical Notch ligand 1

NCBI chr24:11,656,926...11,693,146
Ensembl chr24:11,657,416...11,692,199

NOTCH1

notch receptor 1

ISO

Mutations in the dimerization and/or PEST domain have been associated with human acute T-lymphoblastic leukemias

RGD

PMID:15472075

RGD:1334450

NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277

NOTCH3

notch receptor 3

ISO

Mutations are predominantly found in the EGF repeats and clustered within the first five

RGD

PMID:9388399

RGD:1334441

NCBI chr20:46,946,654...46,978,821
Ensembl chr20:46,937,485...46,978,219

altered p53 signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ETS1

ETS proto-oncogene 1, transcription factor

NCBI chr 5:6,059,023...6,189,516
Ensembl chr 5:6,058,935...6,186,232

MDM2

MDM2 proto-oncogene

ISO

RGD

PMID:19165225 PMID:23262034

RGD:2316186 RGD:8663434

NCBI chr10:10,936,288...10,963,118
Ensembl chr10:10,893,719...10,962,596

MDM4

MDM4 regulator of p53

NCBI chr38:1,055,978...1,122,348
Ensembl chr38:1,056,109...1,107,166

MRE11

MRE11 homolog, double strand break repair nuclease

NCBI chr21:6,448,909...6,528,185
Ensembl chr21:6,449,822...6,527,119

NFYA

nuclear transcription factor Y subunit alpha

ISO

RGD

PMID:22713868 PMID:23263379

RGD:8663430 RGD:8663431

NCBI chr12:9,827,254...9,854,693
Ensembl chr12:9,835,285...9,854,543

NFYB

nuclear transcription factor Y subunit beta

ISO

RGD

PMID:22713868 PMID:23263379

RGD:8663430 RGD:8663431

NCBI chr15:42,608,067...42,628,816
Ensembl chr15:42,609,606...42,629,158

NFYC

nuclear transcription factor Y subunit gamma

ISO

RGD

PMID:22713868 PMID:23263379

RGD:8663430 RGD:8663431

NCBI chr15:2,268,050...2,334,939
Ensembl chr15:2,268,102...2,318,605

PIN1

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

NCBI chr20:51,156,887...51,168,131
Ensembl chr20:51,157,121...51,168,136

SREBF2

sterol regulatory element binding transcription factor 2

ISO

RGD

PMID:22713868 PMID:23263379

RGD:8663430 RGD:8663431

NCBI chr10:23,451,923...23,532,765
Ensembl chr10:23,452,561...23,518,689
Ensembl chr10:23,452,561...23,518,689

TP53

tumor protein p53

ISO

RGD

PMID:18772397 PMID:19078924 PMID:19165225 PMID:20951313 PMID:22713868 More...

RGD:2316186 RGD:4143515 RGD:5133242 RGD:5490966 RGD:8663430 RGD:8663431 RGD:8693397

NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109

TP63

tumor protein p63

ISO

RGD

PMID:22713868 PMID:23263379

RGD:8663430 RGD:8663431

NCBI chr34:21,766,861...21,985,095
Ensembl chr34:21,766,496...21,983,046

TP73

tumor protein p73

ISO

RGD

PMID:22713868 PMID:23263379

RGD:8663430 RGD:8663431

NCBI chr 5:58,194,385...58,241,159
Ensembl chr 5:58,187,826...58,240,839

vitamin D receptor

NCBI chr27:6,852,915...6,909,466
Ensembl chr27:6,852,723...6,909,470

altered phosphatidylinositol 3-kinase signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910

PTEN

phosphatase and tensin homolog

NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176

altered phosphatidylinositol 3-kinase-Akt signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AKT1

AKT serine/threonine kinase 1

ISO

RGD

PMID:18955974 PMID:21277552

RGD:2313763 RGD:5133243

NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193

AKT2

AKT serine/threonine kinase 2

ISO

RGD

PMID:15166380 PMID:18955974 PMID:19506583

RGD:2313408 RGD:2313763 RGD:5490965

NCBI chr 1:113,359,038...113,407,119
Ensembl chr 1:113,359,575...113,407,131

AKT3

AKT serine/threonine kinase 3

NCBI chr 7:34,633,064...34,931,112
Ensembl chr 7:34,636,124...34,931,112

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

ISO

RGD

PMID:18955974 PMID:19078924 PMID:20951313 PMID:21277552

RGD:2313763 RGD:4143515 RGD:5133242 RGD:5133243

NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910

PTEN

phosphatase and tensin homolog

ISO

RGD

PMID:18008377 PMID:18955974 PMID:19078924 PMID:19506583 PMID:20951313

RGD:2313763 RGD:2326139 RGD:4143515 RGD:5133242 RGD:5490965

NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176

altered Reelin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

DAB1

DAB adaptor protein 1

ISO

RGD

PMID:12670697 PMID:12764038 PMID:16266828

RGD:1358468 RGD:2324967 RGD:727518

NCBI chr 5:51,397,837...52,505,513
Ensembl chr 5:52,231,141...52,502,336

FYN

FYN proto-oncogene, Src family tyrosine kinase

NCBI chr12:68,105,060...68,316,630
Ensembl chr12:68,075,184...68,316,541

ITGA3

integrin subunit alpha 3

NCBI chr 9:26,065,792...26,095,649
Ensembl chr 9:26,062,393...26,094,422

ITGB1

integrin subunit beta 1

NCBI chr 2:3,728,472...3,757,696
Ensembl chr 2:3,670,596...3,756,961

LRP8

LDL receptor related protein 8

NCBI chr 5:55,604,878...55,684,666
Ensembl chr 5:55,604,878...55,699,736

PAFAH1B1

platelet activating factor acetylhydrolase 1b regulatory subunit 1

NCBI chr 9:46,648,057...46,731,259
Ensembl chr 9:46,648,052...46,771,400

PAFAH1B2

platelet activating factor acetylhydrolase 1b catalytic subunit 2

platelet activating factor acetylhydrolase 1b catalytic subunit 3

NCBI chr 1:112,078,131...112,080,874
Ensembl chr 1:112,063,074...112,080,873

RELN

reelin

ISO

RGD

PMID:12670697 PMID:12764038

RGD:1358468 RGD:727518

NCBI chr18:16,275,822...16,773,875
Ensembl chr18:16,275,837...16,773,875

SRC

SRC proto-oncogene, non-receptor tyrosine kinase

NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077

VLDLR

very low density lipoprotein receptor

NCBI chr 1:91,242,010...91,277,030
Ensembl chr 1:91,241,509...91,272,495

altered scatter factor/hepatocyte growth factor signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

MET

MET proto-oncogene, receptor tyrosine kinase

ISO

RGD

PMID:19506583 PMID:20519133 PMID:20951313 PMID:21277552

RGD:5133241 RGD:5133242 RGD:5133243 RGD:5490965

NCBI chr14:55,599,047...55,711,626
Ensembl chr14:55,598,337...55,724,027

altered transforming growth factor-beta Smad dependent signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

B9D2

B9 domain containing 2

ISO

RGD

PMID:17613544 PMID:18313409

RGD:2299005 RGD:2306282

NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885

SMAD2

SMAD family member 2

ISO

RGD

PMID:17613544 PMID:18662538

RGD:2306282 RGD:2308865

NCBI chr 7:43,696,883...43,778,063
Ensembl chr 7:43,700,445...43,769,983

SMAD3

SMAD family member 3

ISO

RGD

PMID:17613544 PMID:18772397

RGD:2306282 RGD:5490966

NCBI chr30:31,246,313...31,360,098
Ensembl chr30:31,245,657...31,363,337

SMAD4

SMAD family member 4

ISO

RGD

PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583

RGD:2306282 RGD:2308865 RGD:5490965 RGD:5490966

NCBI chr 1:23,875,989...23,930,027
Ensembl chr 1:23,882,139...23,969,405

SMAD family member 7

NCBI chr 7:79,706,485...79,734,673
Ensembl chr 7:79,706,705...79,734,749

TGFBR1

transforming growth factor beta receptor 1

ISO

RGD

PMID:17613544 PMID:18313409

RGD:2299005 RGD:2306282

NCBI chr11:56,191,383...56,223,042
Ensembl chr11:56,161,772...56,218,594

TGFBR2

transforming growth factor beta receptor 2

ISO

RGD

PMID:17613544 PMID:18313409 PMID:18662538 PMID:18772397 PMID:19506583

RGD:2299005 RGD:2306282 RGD:2308865 RGD:5490965 RGD:5490966

NCBI chr23:13,886,869...13,946,480
Ensembl chr23:13,889,000...13,977,636

altered vascular endothelial growth factor signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

FLT4

fms related receptor tyrosine kinase 4

NCBI chr11:1,145,643...1,184,097
Ensembl chr11:1,145,585...1,185,165

altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

KDR

kinase insert domain receptor

NCBI chr13:47,442,861...47,484,574
Ensembl chr13:47,442,764...47,485,042

VEGFA

vascular endothelial growth factor A

NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965

altered vascular endothelial growth factor signaling pathway involving the main players

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

FLT4

fms related receptor tyrosine kinase 4

NCBI chr11:1,145,643...1,184,097
Ensembl chr11:1,145,585...1,185,165

KDR

kinase insert domain receptor

NCBI chr13:47,442,861...47,484,574
Ensembl chr13:47,442,764...47,485,042

VEGFA

vascular endothelial growth factor A

NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965

altered visual phototransduction pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CNGA1

cyclic nucleotide gated channel subunit alpha 1

NCBI chr13:43,831,159...43,864,276
Ensembl chr13:43,831,163...43,864,276

CNGB1

cyclic nucleotide gated channel subunit beta 1

NCBI chr 2:58,574,552...58,641,631
Ensembl chr 2:58,574,552...58,640,812

GUCA1B

guanylate cyclase activator 1B

NCBI chr12:10,796,961...10,806,796
Ensembl chr12:10,797,921...10,834,237

phosphodiesterase 6A

NCBI chr 4:59,103,965...59,163,857
Ensembl chr 4:59,103,945...59,163,857

phosphodiesterase 6B

NCBI chr 3:91,746,571...91,775,372
Ensembl chr 3:91,746,571...91,775,372

phosphodiesterase 6G

NCBI chr 9:525,123...529,406
Ensembl chr 9:526,577...529,526

rhodopsin

NCBI chr20:5,630,735...5,638,906

SAG

S-antigen visual arrestin

NCBI chr25:44,800,141...44,843,580
Ensembl chr25:44,812,362...44,843,579

altered Wnt signaling, canonical pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

APC

APC regulator of WNT signaling pathway

NCBI chr 3:252,052...380,506
Ensembl chr 3:253,081...322,993

axin 1

NCBI chr 6:40,155,797...40,218,330
Ensembl chr 6:40,158,244...40,218,343

axin 2

NCBI chr 9:14,559,476...14,588,950
Ensembl chr 9:14,559,388...14,588,530

CTNNB1

catenin beta 1

ISO

RGD

PMID:18432252 PMID:19078924

RGD:2293188 RGD:4143515

NCBI chr23:10,559,722...10,572,933
Ensembl chr23:10,559,718...10,572,927

LRP5

LDL receptor related protein 5

NCBI chr18:49,439,494...49,555,375
Ensembl chr18:49,439,483...49,516,396

MAP3K1

mitogen-activated protein kinase kinase kinase 1

NCBI chr 2:43,918,210...43,996,817
Ensembl chr 2:43,917,604...43,995,209

TCF7L2

transcription factor 7 like 2

NCBI chr28:23,966,079...24,162,775
Ensembl chr28:23,966,073...24,163,737

Wnt family member 9A

NCBI chr14:946,843...959,289
Ensembl chr14:953,244...959,295

androgen signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

androgen receptor

NCBI chr24:34,713,390...34,731,461
NCBI chr X:51,969,785...52,167,450
Ensembl chr X:51,969,785...52,151,912

CARM1

coactivator associated arginine methyltransferase 1

NCBI chr20:50,328,466...50,371,845
Ensembl chr20:50,331,030...50,348,195

CREB binding protein

NCBI chr 6:37,410,201...37,536,688
Ensembl chr 6:37,409,930...37,534,176

DNAJA2

DnaJ heat shock protein family (Hsp40) member A2

NCBI chr 2:67,903,292...67,916,267

EP300

E1A binding protein p300

NCBI chr10:24,076,538...24,156,708
Ensembl chr10:24,077,971...24,156,396

HSP90AA1

heat shock protein 90 alpha family class A member 1

NCBI chr 8:70,091,203...70,096,107
Ensembl chr 8:70,092,217...70,095,243

HSP90AB1

heat shock protein 90 alpha family class B member 1

NCBI chr12:12,658,415...12,664,945
Ensembl chr12:12,660,008...12,664,940

HSPA8

heat shock protein family A (Hsp70) member 8

NCBI chr 5:11,292,219...11,296,851
Ensembl chr 5:11,292,262...11,296,797

NCOA1

nuclear receptor coactivator 1

NCBI chr17:18,880,676...19,124,300
Ensembl chr17:18,880,383...19,122,258

NCOA2

nuclear receptor coactivator 2

NCBI chr29:19,253,849...19,471,640
Ensembl chr29:19,222,842...19,545,371

NCOA3

nuclear receptor coactivator 3

Ensembl chr24:34,585,305...34,728,674
Ensembl chr24:34,585,305...34,728,674

NCOR1

nuclear receptor corepressor 1

NCBI chr 5:39,687,530...39,837,003
Ensembl chr 5:39,687,543...39,836,464

NCOR2

nuclear receptor corepressor 2

NCBI chr26:5,352,670...5,493,741
Ensembl chr26:5,331,459...5,493,830

PIAS2

protein inhibitor of activated STAT 2

NCBI chr 7:44,436,100...44,583,657
Ensembl chr 7:44,454,095...44,583,657

PRMT1

protein arginine methyltransferase 1

NCBI chr 1:106,849,864...106,859,896
Ensembl chr 1:106,849,864...106,874,075

ST13

ST13 Hsp70 interacting protein

NCBI chr10:24,379,997...24,411,764
Ensembl chr10:24,379,997...24,411,766

STIP1

stress induced phosphoprotein 1

NCBI chr18:52,854,262...52,868,187
Ensembl chr18:52,854,663...52,868,478

angiopoietin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

angiopoietin 1

NCBI chr13:8,068,920...8,312,090
Ensembl chr13:8,048,205...8,311,618

TEK

TEK receptor tyrosine kinase

NCBI chr11:45,278,375...45,377,300
Ensembl chr11:45,278,891...45,409,093

angiotensin (1-7) signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACE

angiotensin I converting enzyme

ISO

RGD

PMID:10642323 PMID:15283675

RGD:1581953 RGD:1598433

NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358

ACE2

angiotensin converting enzyme 2

NCBI chr X:11,798,839...11,839,591
Ensembl chr X:11,798,839...11,900,594

angiotensinogen

NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880

MAS1

MAS1 proto-oncogene, G protein-coupled receptor

ISO

RGD

PMID:15951342 PMID:16520407

RGD:1581931 RGD:1581938

NCBI chr 1:49,090,041...49,105,244
Ensembl chr 1:49,090,041...49,105,244

MME

membrane metalloendopeptidase

ISO

RGD

PMID:10642323 PMID:15638741 PMID:16520407

RGD:1581742 RGD:1581931 RGD:1581953

NCBI chr23:48,966,222...49,059,919
Ensembl chr23:48,971,066...49,059,919

angiotensin II signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACE

angiotensin I converting enzyme

NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358

angiotensinogen

NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880

AGTR1

angiotensin II receptor type 1

NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238

AGTR2

angiotensin II receptor type 2

NCBI chr X:88,703,551...88,708,451
Ensembl chr X:88,705,765...88,706,853

CCL2

C-C motif chemokine ligand 2

NCBI chr 9:39,008,187...39,009,932

CMA1

chymase 1

ISO

RGD

PMID:15638741 PMID:15869764

RGD:1581742 RGD:1581745

NCBI chr 8:4,438,244...4,441,189
Ensembl chr 8:4,438,244...4,441,189

Janus kinase 2

NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997

OLR1

oxidized low density lipoprotein receptor 1

NCBI chr27:35,828,852...35,838,748
Ensembl chr27:35,828,029...35,838,754

PDPK1

3-phosphoinositide dependent protein kinase 1

NCBI chr 6:38,426,464...38,506,520
Ensembl chr 6:38,431,600...38,499,295

PLA2G6

phospholipase A2 group VI

NCBI chr10:26,499,033...26,559,533
Ensembl chr10:26,509,695...26,634,087

PRKCZ

protein kinase C zeta

NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664

angiotensin II signaling pathway via AT1 receptor

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

angiotensinogen

NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880

AGTR1

angiotensin II receptor type 1

ISO

RGD

PMID:9287353 PMID:10977869 PMID:12446719 PMID:14559250

RGD:1581825 RGD:2316188 RGD:5133683 RGD:629553

NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238

AGTRAP

angiotensin II receptor associated protein

NCBI chr 2:84,489,269...84,501,732
Ensembl chr 2:84,490,638...84,501,919

ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

NCBI chr21:25,468,653...25,531,644
Ensembl chr21:25,443,386...25,531,165

arrestin beta 1

NCBI chr21:23,261,020...23,304,448
Ensembl chr21:23,235,711...23,297,786

arrestin beta 2

NCBI chr 5:31,831,208...31,838,875
Ensembl chr 5:31,829,864...31,839,454

GNA11

G protein subunit alpha 11

G protein subunit alpha q

NCBI chr 1:80,733,530...80,928,065
Ensembl chr 1:80,715,366...80,928,065

GRK2

G protein-coupled receptor kinase 2

NCBI chr18:50,148,566...50,167,422
Ensembl chr18:50,148,598...50,167,428

GRK3

G protein-coupled receptor kinase 3

NCBI chr26:19,385,059...19,512,528
Ensembl chr26:19,385,058...19,516,077

GRK5

G protein-coupled receptor kinase 5

NCBI chr28:29,424,350...29,636,552
Ensembl chr28:29,424,593...29,632,741

GRK6

G protein-coupled receptor kinase 6

NCBI chr 4:35,927,470...35,943,218
Ensembl chr 4:35,913,472...35,943,221

JAK2

Janus kinase 2

ISO

RGD

PMID:9287353 PMID:9314843

RGD:5133683 RGD:6478796

NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997

RGS2

regulator of G protein signaling 2

NCBI chr38:6,200,237...6,203,491
Ensembl chr38:6,200,657...6,203,494

tyrosine kinase 2

NCBI chr20:50,747,145...50,770,008
Ensembl chr20:50,748,329...50,769,216

angiotensin II signaling pathway via AT2 receptor

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AGT

angiotensinogen

ISO

RGD

PMID:16286564 PMID:16286568 PMID:22949090

RGD:1582434 RGD:1582435 RGD:7401256

NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880

AGTR2

angiotensin II receptor type 2

ISO

RGD

PMID:10977869 PMID:22949090

RGD:1581825 RGD:7401256

NCBI chr X:88,703,551...88,708,451
Ensembl chr X:88,705,765...88,706,853

DUSP1

dual specificity phosphatase 1

NCBI chr 4:39,588,833...39,591,065
Ensembl chr 4:39,588,339...39,590,514

ERBB3

erb-b2 receptor tyrosine kinase 3

NCBI chr10:406,856...424,746
Ensembl chr10:406,633...424,264

GNAI2

G protein subunit alpha i2

NCBI chr20:39,075,085...39,094,697
Ensembl chr20:39,075,085...39,094,697

GNAI3

G protein subunit alpha i3

NCBI chr 6:42,275,060...42,315,545
Ensembl chr 6:42,276,998...42,315,533

MTUS1

microtubule associated scaffold protein 1

NCBI chr16:40,955,619...41,118,601
Ensembl chr16:40,957,574...41,068,967

PTPN6

protein tyrosine phosphatase non-receptor type 6

NCBI chr27:38,084,976...38,101,552
Ensembl chr27:38,084,980...38,101,937

SLC9A6

solute carrier family 9 member A6

NCBI chr X:106,408,789...106,465,504
Ensembl chr X:106,398,850...106,463,252

TIMP3

TIMP metallopeptidase inhibitor 3

NCBI chr10:30,627,154...30,681,520
Ensembl chr10:30,627,154...30,694,288

ZBTB16

zinc finger and BTB domain containing 16

NCBI chr 5:19,082,594...19,284,360
Ensembl chr 5:19,087,154...19,267,628

angiotensin III signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

angiotensinogen

NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880

AGTR1

angiotensin II receptor type 1

NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238

AGTR2

angiotensin II receptor type 2

NCBI chr X:88,703,551...88,708,451
Ensembl chr X:88,705,765...88,706,853

ENPEP

glutamyl aminopeptidase

ISO

RGD

PMID:15638741 PMID:16537183

RGD:1581649 RGD:1581742

NCBI chr32:30,553,055...30,639,790
Ensembl chr32:30,553,182...30,638,522

angiotensin III signaling pathway via AT1 receptor

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

angiotensinogen

NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880

AGTR1

angiotensin II receptor type 1

NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238

angiotensin III signaling pathway via AT2 receptor

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

angiotensinogen

NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880

AGTR2

angiotensin II receptor type 2

NCBI chr X:88,703,551...88,708,451
Ensembl chr X:88,705,765...88,706,853

angiotensin IV signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

angiotensinogen

NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880

ANPEP

alanyl aminopeptidase, membrane

ISO

RGD

PMID:15638741 PMID:16537183

RGD:1581649 RGD:1581742

NCBI chr 3:52,764,418...52,779,516
Ensembl chr 3:52,764,418...52,779,746

LNPEP

leucyl and cystinyl aminopeptidase

ISO

RGD

PMID:11282364 PMID:12591177

RGD:1581864 RGD:1582105

NCBI chr 3:12,668,994...12,766,712
Ensembl chr 3:12,681,577...12,767,183

RNPEP

arginyl aminopeptidase

NCBI chr 7:966,563...985,169
Ensembl chr 7:966,607...984,714

angiotensin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

angiotensinogen

NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880

apelin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

apelin

NCBI chr X:100,863,360...100,873,105

apelin receptor

NCBI chr18:38,878,621...38,882,280
Ensembl chr18:38,878,947...38,886,206

Arf family mediated signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AP2A1

adaptor related protein complex 2 subunit alpha 1

ISO

PID

PID:200195

NCBI chr 1:106,752,326...106,784,803
Ensembl chr 1:106,751,800...106,784,663

AP2M1

adaptor related protein complex 2 subunit mu 1

ISO

PID

PID:200195

NCBI chr34:17,071,199...17,080,445
Ensembl chr34:17,071,235...17,080,445

ARF1

ADP ribosylation factor 1

ISO

PID

PID:200195

NCBI chr14:835,476...836,424
Ensembl chr14:835,476...836,424

ARFGAP1

ADP ribosylation factor GTPase activating protein 1

ISO

PID

PID:200195

NCBI chr24:46,983,944...46,995,552
Ensembl chr24:46,983,939...46,995,548

ARFIP2

ADP ribosylation factor interacting protein 2

ISO

PID

PID:200195

NCBI chr21:29,793,325...29,798,223
Ensembl chr21:29,791,813...29,798,172

ARL6

ADP ribosylation factor like GTPase 6

NCBI chr33:4,797,944...4,857,566
Ensembl chr33:4,800,917...4,839,635

ASAP1

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

ISO

PID

PID:200195

NCBI chr13:27,111,785...27,468,476
Ensembl chr13:27,113,994...27,430,758

CD4

CD4 molecule

ISO

PID

PID:200195

NCBI chr27:38,204,003...38,250,771
Ensembl chr27:38,204,003...38,250,771

CLTA

clathrin light chain A

ISO

PID

PID:200195

NCBI chr11:52,636,328...52,681,258
Ensembl chr11:52,615,039...52,681,270

CLTB

clathrin light chain B

ISO

PID

PID:200195

NCBI chr 4:36,915,106...36,935,565
Ensembl chr 4:36,791,891...36,935,278

COPA

COPI coat complex subunit alpha

ISO

PID

PID:200195

NCBI chr38:21,892,995...21,936,076
Ensembl chr38:21,892,993...21,936,458

CYTH2

cytohesin 2

ISO

PID

PID:200195

NCBI chr 1:107,794,560...107,803,345
Ensembl chr 1:107,794,560...107,803,016

GBF1

golgi brefeldin A resistant guanine nucleotide exchange factor 1

ISO

PID

PID:200195

NCBI chr28:14,775,431...14,896,121
Ensembl chr28:14,788,369...14,895,978

GGA3

golgi associated, gamma adaptin ear containing, ARF binding protein 3

ISO

PID

PID:200195

NCBI chr 9:5,235,377...5,250,982
Ensembl chr 9:5,235,025...5,249,361

GIT ArfGAP 1

NCBI chr 9:43,676,707...43,686,566
Ensembl chr 9:43,677,899...43,693,177

GOSR2

golgi SNAP receptor complex member 2

ISO

PID

PID:200195

NCBI chr 9:10,201,625...10,220,688

KDELR1

KDEL endoplasmic reticulum protein retention receptor 1

ISO

PID

PID:200195

NCBI chr 1:107,860,187...107,869,522

PIP5K1A

phosphatidylinositol-4-phosphate 5-kinase type 1 alpha

ISO

PID

PID:200195

NCBI chr17:60,257,017...60,295,866
Ensembl chr17:60,257,332...60,295,866

PLD2

phospholipase D2

ISO

PID

PID:200195

NCBI chr 5:31,755,881...31,767,131
Ensembl chr 5:31,756,433...31,767,066

RAC1

Rac family small GTPase 1

ISO

PID

PID:200195

NCBI chr 6:11,726,259...11,758,532
Ensembl chr 6:11,655,494...11,757,216

USO1

USO1 vesicle transport factor

ISO

PID

PID:200195

NCBI chr32:305,895...395,113
Ensembl chr32:305,935...394,896

aryl hydrocarbon receptor signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AHR

aryl hydrocarbon receptor

NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444

ARNT

aryl hydrocarbon receptor nuclear translocator

Ensembl chr17:59,941,353...60,010,867
Ensembl chr17:59,941,353...60,010,867

ARNT2

aryl hydrocarbon receptor nuclear translocator 2

NCBI chr 3:57,005,106...57,139,585
Ensembl chr 3:57,008,570...57,159,713

ataxia telangiectasia-mutated (ATM) signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ATM

ATM serine/threonine kinase

ISO

RGD

PMID:21533982 PMID:23532176

RGD:8661225 RGD:8661232

NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207

BAZ1B

bromodomain adjacent to zinc finger domain 1B

NCBI chr 6:6,709,648...6,776,904
Ensembl chr 6:6,709,697...6,776,867

BRCA1

BRCA1 DNA repair associated

NCBI chr 9:19,958,941...20,025,494
Ensembl chr 9:19,958,391...20,025,494

BRCC3

BRCA1/BRCA2-containing complex subunit 3

NCBI chr X:123,081,262...123,143,509
Ensembl chr X:123,081,050...123,140,133

EYA1

EYA transcriptional coactivator and phosphatase 1

NCBI chr29:20,176,306...20,595,131
Ensembl chr29:20,177,014...20,525,653

EYA3

EYA transcriptional coactivator and phosphatase 3

NCBI chr 2:72,313,412...72,417,729
Ensembl chr 2:72,328,362...72,414,058

H2AX

H2A.X variant histone

ISO

RGD

PMID:21533982 PMID:24002223

RGD:8661232 RGD:8661242

NCBI chr 5:14,765,625...14,766,590
Ensembl chr 5:14,766,126...14,766,557

KAT5

lysine acetyltransferase 5

ISO

RGD

PMID:21533982 PMID:23532176

RGD:8661225 RGD:8661232

NCBI chr18:51,499,615...51,507,434
Ensembl chr18:51,499,938...51,576,699

KDM4A

lysine demethylase 4A

ISO

RGD

PMID:24002223 PMID:24326623

RGD:8661237 RGD:8661242

NCBI chr15:16,521,760...16,570,965
Ensembl chr15:16,521,700...16,571,000

L3MBTL1

L3MBTL histone methyl-lysine binding protein 1

ISO

RGD

PMID:24002223 PMID:24326623

RGD:8661237 RGD:8661242

NCBI chr24:31,238,787...31,266,062
Ensembl chr24:31,217,184...31,265,291

MDC1

mediator of DNA damage checkpoint 1

ISO

RGD

PMID:21533982 PMID:24002223

RGD:8661232 RGD:8661242

NCBI chr12:496,353...509,812
Ensembl chr12:496,878...507,442

MRE11

MRE11 homolog, double strand break repair nuclease

NCBI chr21:6,448,909...6,528,185
Ensembl chr21:6,449,822...6,527,119

nibrin

NCBI chr29:35,416,093...35,477,569
Ensembl chr29:35,416,093...35,477,563

OTUB1

OTU deubiquitinase, ubiquitin aldehyde binding 1

NCBI chr 3:40,225,531...40,226,507
Ensembl chr 3:40,225,474...40,226,612
Ensembl chr18:40,225,474...40,226,612

PIAS1

protein inhibitor of activated STAT 1

NCBI chr30:32,116,363...32,232,530
Ensembl chr30:32,119,311...32,228,945

PIAS4

protein inhibitor of activated STAT 4

NCBI chr20:55,529,841...55,553,604
Ensembl chr20:55,524,443...55,553,525

PPM1D

protein phosphatase, Mg2+/Mn2+ dependent 1D

ISO

RGD

PMID:21533982 PMID:24002223

RGD:8661232 RGD:8661242

NCBI chr 9:35,856,277...35,914,096
Ensembl chr 9:35,856,765...35,913,884

PPP2CA

protein phosphatase 2 catalytic subunit alpha

ISO

RGD

PMID:21533982 PMID:24002223

RGD:8661232 RGD:8661242

NCBI chr11:22,388,327...22,410,052
Ensembl chr11:22,385,257...22,410,052

PPP4C

protein phosphatase 4 catalytic subunit

NCBI chr 6:18,085,048...18,092,861
Ensembl chr 6:18,085,116...18,092,854

PPP5C

protein phosphatase 5 catalytic subunit

NCBI chr 1:109,453,768...109,470,933
Ensembl chr 1:109,454,107...109,467,087

PPP6C

protein phosphatase 6 catalytic subunit

NCBI chr 9:57,884,035...57,921,080
Ensembl chr 5:43,094,942...43,095,395
Ensembl chr 9:43,094,942...43,095,395

PSMD14

proteasome 26S subunit, non-ATPase 14

NCBI chr36:6,883,612...6,985,291
Ensembl chr36:6,889,622...6,984,974

PWWP3A

PWWP domain containing 3A, DNA repair factor

NCBI chr20:57,452,289...57,469,207
Ensembl chr20:57,452,300...57,468,692

RAD50

RAD50 double strand break repair protein

NCBI chr11:20,836,863...20,928,930
Ensembl chr11:20,836,879...20,928,819

RBBP8

RB binding protein 8, endonuclease

NCBI chr 7:65,218,288...65,319,696
Ensembl chr 7:65,218,297...65,297,099

RIF1

replication timing regulatory factor 1

NCBI chr19:52,661,278...52,711,969
Ensembl chr19:52,661,155...52,709,279

RNF168

ring finger protein 168

ISO

RGD

PMID:21533982 PMID:24326623

RGD:8661232 RGD:8661237

NCBI chr33:29,542,209...29,575,127
Ensembl chr33:29,539,182...29,628,248

RNF20

ring finger protein 20

NCBI chr11:58,239,245...58,266,637
Ensembl chr11:58,239,313...58,265,866

RNF4

ring finger protein 4

NCBI chr 3:61,721,752...61,759,797
Ensembl chr 3:61,723,124...61,759,730

RNF40

ring finger protein 40

NCBI chr 6:17,402,022...17,414,494
Ensembl chr 6:17,402,908...17,414,362

RNF8

ring finger protein 8

ISO

RGD

PMID:21533982 PMID:24326623

RGD:8661232 RGD:8661237

NCBI chr12:6,380,365...6,415,407
Ensembl chr12:6,292,459...6,415,382

TP53BP1

tumor protein p53 binding protein 1

NCBI chr30:10,263,650...10,362,646
Ensembl chr30:10,263,650...10,336,134

TRIP12

thyroid hormone receptor interactor 12

NCBI chr25:42,060,103...42,208,326
Ensembl chr25:42,060,991...42,208,054

UBE2N

ubiquitin conjugating enzyme E2 N

ISO

RGD

PMID:21533982 PMID:24326623

RGD:8661232 RGD:8661237

NCBI chr10:41,470,073...41,470,738
Ensembl chr10:41,470,073...41,470,738

UBR5

ubiquitin protein ligase E3 component n-recognin 5

NCBI chr13:3,887,408...4,023,364
Ensembl chr13:3,879,220...4,023,955

USP16

ubiquitin specific peptidase 16

NCBI chr31:24,034,399...24,060,268
Ensembl chr31:24,034,448...24,059,874

USP3

ubiquitin specific peptidase 3

NCBI chr30:28,073,484...28,184,121
Ensembl chr30:28,072,655...28,181,749

USP44

ubiquitin specific peptidase 44

NCBI chr15:35,401,486...35,454,351
Ensembl chr15:35,402,207...35,414,261

VCP

valosin containing protein

ISO

RGD

PMID:24002223 PMID:24326623

RGD:8661237 RGD:8661242

NCBI chr11:51,636,986...51,651,749
Ensembl chr11:51,637,411...51,651,714

atrial natriuretic peptide signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CORIN

corin, serine peptidase

NCBI chr13:43,501,287...43,737,522
Ensembl chr13:43,502,665...43,737,813

NPPA

natriuretic peptide A

ISO

RGD

PMID:12608696 PMID:15758553 PMID:16010968

RGD:1578335 RGD:1580001 RGD:1626242

NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385

NPR1

natriuretic peptide receptor 1

NCBI chr 7:43,382,246...43,396,464
Ensembl chr 7:43,283,418...43,396,027

auditory mechanotransduction pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

actin beta

NCBI chr 6:12,421,006...12,424,449
Ensembl chr 6:12,418,932...12,462,845

actin gamma 1

NCBI chr 9:635,978...638,328
Ensembl chr 9:635,978...638,328

ADGRV1

adhesion G protein-coupled receptor V1

NCBI chr 3:17,866,459...18,351,532
Ensembl chr 3:17,866,808...18,351,532

CDH23

cadherin related 23

ISO

RGD

PMID:19804752 PMID:22177415

RGD:8547667 RGD:8547671

NCBI chr 4:22,206,972...22,570,875
Ensembl chr 4:22,207,001...22,571,131

ESPN

espin

ISO

RGD

PMID:19804752 PMID:20624897

RGD:8547667 RGD:8547669

NCBI chr 5:60,285,185...60,316,261
Ensembl chr 5:60,285,312...60,315,676

myosin XVA

NCBI chr 5:41,369,484...41,421,303
Ensembl chr 5:41,370,509...41,392,881

myosin IC

NCBI chr 9:45,635,295...45,658,226
Ensembl chr 9:45,636,208...45,658,035

myosin IIIA

NCBI chr 2:7,455,125...7,695,483
Ensembl chr 2:7,455,625...7,696,043

MYO6

myosin VI

ISO

RGD

PMID:20624897 PMID:22715884

RGD:8547669 RGD:8547672

NCBI chr12:37,359,200...37,502,342
Ensembl chr12:37,413,570...37,500,724

MYO7A

myosin VIIA

ISO

RGD

PMID:19804752 PMID:22177415

RGD:8547667 RGD:8547671

NCBI chr21:21,539,735...21,624,063
Ensembl chr21:21,539,785...21,624,279

otoferlin

NCBI chr17:20,518,480...20,619,713
Ensembl chr17:20,518,813...20,614,750

PCDH15

protocadherin related 15

ISO

RGD

PMID:19804752 PMID:22177415

RGD:8547667 RGD:8547671

NCBI chr26:33,426,728...34,589,208
Ensembl chr26:33,719,839...34,588,017

plastin 1

NCBI chr23:38,243,631...38,347,195
Ensembl chr23:38,243,024...38,347,202

plastin 3

NCBI chr X:88,308,817...88,399,682
Ensembl chr X:88,308,888...88,398,810

PTPRQ

protein tyrosine phosphatase receptor type Q

NCBI chr15:22,771,653...23,017,694
Ensembl chr15:22,825,348...23,013,762

SLC17A8

solute carrier family 17 member 8

NCBI chr15:39,443,790...39,489,988
Ensembl chr15:39,443,518...39,486,595

USH1C

USH1 protein network component harmonin

ISO

RGD

PMID:19804752 PMID:22177415

RGD:8547667 RGD:8547671

NCBI chr21:40,055,786...40,100,685
Ensembl chr21:40,055,730...40,101,430

USH1G

USH1 protein network component sans

NCBI chr 9:5,527,935...5,532,940
Ensembl chr 9:5,528,492...5,533,900

usherin

NCBI chr38:11,063,221...11,750,444
Ensembl chr38:11,063,817...11,750,444

whirlin

NCBI chr11:68,617,383...68,699,824
Ensembl chr11:68,617,377...68,699,977

bile acid signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ABCB11

ATP binding cassette subfamily B member 11

NCBI chr36:13,742,895...13,835,312
Ensembl chr36:13,746,964...13,834,974

ABCC2

ATP binding cassette subfamily C member 2

NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740

ABCC4

ATP binding cassette subfamily C member 4

NCBI chr22:45,767,033...46,013,577
Ensembl chr22:45,765,835...46,013,505

ABCG5

ATP binding cassette subfamily G member 5

NCBI chr10:46,261,747...46,300,084
Ensembl chr10:46,271,772...46,299,773

ABCG8

ATP binding cassette subfamily G member 8

NCBI chr10:46,300,142...46,319,592
Ensembl chr10:46,300,165...46,319,229

ACAT2

acetyl-CoA acetyltransferase 2

NCBI chr 1:49,011,665...49,029,368
Ensembl chr 1:49,011,706...49,029,327

ALDH1L1

aldehyde dehydrogenase 1 family member L1

NCBI chr20:52,722...99,180
Ensembl chr20:61,349...99,160

CIDEB

cell death inducing DFFA like effector b

NCBI chr 8:4,275,700...4,278,612

CYP27A1

cytochrome P450 family 27 subfamily A member 1

NCBI chr37:25,366,475...25,401,978
Ensembl chr37:25,366,472...25,401,509

CYP7A1

cytochrome P450 family 7 subfamily A member 1

ISO

RGD

PMID:28774887 PMID:30223280

RGD:15045601 RGD:15045612

NCBI chr29:9,285,315...9,295,895
Ensembl chr29:9,286,181...9,332,310

CYP8B1

cytochrome P450 family 8 subfamily B member 1

NCBI chr23:11,965,685...11,968,994
Ensembl chr23:11,967,341...11,968,846

DGAT2

diacylglycerol O-acyltransferase 2

NCBI chr21:22,833,659...22,850,300
Ensembl chr21:22,834,518...22,851,260

HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

NCBI chr 3:30,970,037...30,988,987
Ensembl chr 3:30,970,037...30,990,294

NR1H3

nuclear receptor subfamily 1 group H member 3

NCBI chr18:42,333,173...42,346,152
Ensembl chr18:42,333,202...42,341,236

NR1H4

nuclear receptor subfamily 1 group H member 4

ISO

RGD

PMID:25263431 PMID:27090119 PMID:28774887 PMID:29235094 PMID:30061734 More...

RGD:15042870 RGD:15042872 RGD:15045601 RGD:15045610 RGD:15045612 RGD:15090804 RGD:15092071

NCBI chr15:39,497,313...39,608,120
Ensembl chr15:39,536,290...39,608,116

PRKAA1

protein kinase AMP-activated catalytic subunit alpha 1

NCBI chr 4:68,579,061...68,614,548
Ensembl chr 4:68,579,037...68,611,841

SLC10A1

solute carrier family 10 member 1

NCBI chr 8:43,521,291...43,546,426
Ensembl chr 8:43,521,747...43,546,274

SLCO1A2

solute carrier organic anion transporter family member 1A2

NCBI chr27:26,279,654...26,398,000
Ensembl chr27:26,279,547...26,425,818

Bone morphogenetic proteins signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AHSG

alpha 2-HS glycoprotein

ISO

PID

PID:200144

NCBI chr34:19,221,034...19,228,866
Ensembl chr34:19,221,107...19,228,716

BAMBI

BMP and activin membrane bound inhibitor

ISO

PID

PID:200144

NCBI chr 2:17,453,628...17,459,812
Ensembl chr 2:17,455,243...17,462,346

BMP2

bone morphogenetic protein 2

ISO

PID
RGD

PMID:16361357

PID:200144 RGD:1580077

NCBI chr24:15,199,667...15,211,509
Ensembl chr24:15,200,291...15,212,217

BMP4

bone morphogenetic protein 4

ISO

PID
RGD

PMID:18985159

PID:200144 RGD:11553861

NCBI chr 8:29,997,563...30,254,307
Ensembl chr 8:29,997,569...30,004,557

BMP6

bone morphogenetic protein 6

ISO

PID

PID:200144

NCBI chr35:7,780,763...7,833,095
Ensembl chr35:7,804,231...7,831,845

BMP7

bone morphogenetic protein 7

ISO

PID

PID:200144

NCBI chr24:42,203,183...42,294,105
Ensembl chr24:42,204,823...42,294,653

BMPR1A

bone morphogenetic protein receptor type 1A

ISO

PID

PID:200144

NCBI chr 4:34,499,898...34,582,481
Ensembl chr 4:34,517,492...34,578,923

BMPR1B

bone morphogenetic protein receptor type 1B

ISO

PID

PID:200144

NCBI chr32:17,761,555...17,978,056
Ensembl chr32:17,870,904...18,016,444

BMPR2

bone morphogenetic protein receptor type 2

ISO

RGD
PID

PMID:16361357

PID:200144 RGD:1580077

NCBI chr37:11,342,292...11,540,199
Ensembl chr37:11,342,384...11,533,024

CER1

cerberus 1, DAN family BMP antagonist

ISO

PID

PID:200144

NCBI chr11:35,155,568...35,159,085
Ensembl chr11:35,156,430...35,158,942

CHRD

chordin

ISO

PID

PID:200144

NCBI chr34:17,255,770...17,264,776
Ensembl chr34:17,255,562...17,271,713

CHRDL1

chordin like 1

ISO

PID

PID:200144

NCBI chr X:83,816,131...83,936,497
Ensembl chr X:83,817,880...83,936,949

CTDSP1

CTD small phosphatase 1

ISO

PID

PID:200144

NCBI chr37:25,051,839...25,057,506
Ensembl chr37:25,050,267...25,056,113

CTDSP2

CTD small phosphatase 2

ISO

PID

PID:200144

NCBI chr10:1,875,307...1,898,385
Ensembl chr10:1,876,536...1,898,348

CTDSPL

CTD small phosphatase like

ISO

PID

PID:200144

NCBI chr23:7,616,264...7,760,595
Ensembl chr23:7,725,446...7,758,067

FST

follistatin

ISO

PID

PID:200144

NCBI chr 4:61,779,252...61,785,666
Ensembl chr 4:61,779,259...61,783,260

GREM1

gremlin 1, DAN family BMP antagonist

ISO

PID

PID:200144

NCBI chr30:2,219,535...2,231,868
Ensembl chr30:2,222,898...2,225,418

GSK3B

glycogen synthase kinase 3 beta

ISO

PID

PID:200144

NCBI chr33:23,458,369...23,659,878
Ensembl chr33:23,463,767...23,659,666

HJV

hemojuvelin BMP co-receptor

ISO

PID

PID:200144

NCBI chr17:58,792,647...58,797,504
Ensembl chr17:58,793,247...58,797,373

MAP3K7

mitogen-activated protein kinase kinase kinase 7

ISO

PID

PID:200144

NCBI chr12:49,669,849...49,740,039
Ensembl chr12:49,672,389...49,739,850

MAPK1

mitogen-activated protein kinase 1

ISO

PID

PID:200144

NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998

NOG

noggin

ISO

PID

PID:200144

NCBI chr 9:31,453,604...31,456,060

NUP214

nucleoporin 214

ISO

PID

PID:200144

NCBI chr 9:52,840,300...52,943,785
Ensembl chr 9:52,841,096...52,947,770

PPM1A

protein phosphatase, Mg2+/Mn2+ dependent 1A

ISO

PID

PID:200144

NCBI chr 8:35,336,055...35,384,249
Ensembl chr 8:35,336,140...35,377,551

PPP1CA

protein phosphatase 1 catalytic subunit alpha

ISO

PID

PID:200144

NCBI chr18:50,062,352...50,065,166
Ensembl chr18:50,062,352...50,065,166

PPP1R15A

protein phosphatase 1 regulatory subunit 15A

ISO

PID

PID:200144

NCBI chr 1:107,486,399...107,490,151
Ensembl chr 1:107,486,438...107,489,222

RGMA

repulsive guidance molecule BMP co-receptor a

ISO

PID

PID:200144

NCBI chr 3:47,044,342...47,089,923
Ensembl chr 3:47,061,910...47,089,294

RGMB

repulsive guidance molecule BMP co-receptor b

ISO

PID

PID:200144

NCBI chr 3:11,407,426...11,427,317

SKI

SKI proto-oncogene

ISO

PID

PID:200144

NCBI chr 5:57,144,178...57,216,385
Ensembl chr 5:57,145,825...57,214,403

SLC39A13

solute carrier family 39 member 13

NCBI chr18:42,221,311...42,229,992
Ensembl chr18:42,222,333...42,227,361

SMAD1

SMAD family member 1

ISO

RGD
PID

PMID:16361357 PMID:18985159

PID:200144 RGD:11553861 RGD:1580077

NCBI chr15:44,093,491...44,171,177
Ensembl chr15:44,095,497...44,170,098

SMAD4

SMAD family member 4

ISO

PID

PID:200144

NCBI chr 1:23,875,989...23,930,027
Ensembl chr 1:23,882,139...23,969,405

SMAD5

SMAD family member 5

ISO

RGD
PID

PMID:16361357 PMID:18985159

PID:200144 RGD:11553861 RGD:1580077

NCBI chr11:24,027,603...24,082,673
Ensembl chr11:24,028,126...24,078,169

SMAD6

SMAD family member 6

ISO

PID

PID:200144

NCBI chr30:30,938,908...31,014,259
Ensembl chr30:30,937,849...31,014,583

SMAD7

SMAD family member 7

ISO

PID

PID:200144

NCBI chr 7:79,706,485...79,734,673
Ensembl chr 7:79,706,705...79,734,749

SMAD family member 9

PID:200144 RGD:1580077

NCBI chr25:3,768,851...3,844,645
Ensembl chr25:3,779,197...3,841,321

SMURF1

SMAD specific E3 ubiquitin protein ligase 1

ISO

PID

PID:200144

NCBI chr 6:10,385,781...10,498,071
Ensembl chr 6:10,385,779...10,494,922

SMURF2

SMAD specific E3 ubiquitin protein ligase 2

ISO

PID

PID:200144

NCBI chr 9:12,348,777...12,472,636
Ensembl chr 9:12,351,627...12,471,467

SOSTDC1

sclerostin domain containing 1

ISO

PID

PID:200144

NCBI chr14:31,035,759...31,079,139
Ensembl chr14:31,022,766...31,026,737
Ensembl chr14:31,022,766...31,026,737

TAB1

TGF-beta activated kinase 1 (MAP3K7) binding protein 1

ISO

PID

PID:200144

NCBI chr10:25,623,381...25,657,630
Ensembl chr10:25,623,940...25,657,543

TAB2

TGF-beta activated kinase 1 (MAP3K7) binding protein 2

ISO

PID

PID:200144

NCBI chr 1:40,125,842...40,216,455
Ensembl chr 1:40,149,569...40,215,385

XIAP

X-linked inhibitor of apoptosis

ISO

PID

PID:200144

NCBI chr X:95,300,234...95,356,103
Ensembl chr X:95,331,827...95,351,582

ZFYVE16

zinc finger FYVE-type containing 16

ISO

PID

PID:200144

NCBI chr 3:26,662,750...26,714,184
Ensembl chr 3:26,664,068...26,699,073

brain natriuretic peptide signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

NPPB

natriuretic peptide B

NCBI chr 2:84,395,844...84,397,473

NPR1

natriuretic peptide receptor 1

NCBI chr 7:43,382,246...43,396,464
Ensembl chr 7:43,283,418...43,396,027

brain-derived neurotrophic factor signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BDNF

brain derived neurotrophic factor

NCBI chr21:48,191,580...48,243,699
Ensembl chr21:48,192,670...48,204,480

FRS2

fibroblast growth factor receptor substrate 2

NCBI chr10:11,445,843...11,552,325
Ensembl chr10:11,539,994...11,552,890

GRB2

growth factor receptor bound protein 2

NCBI chr 9:5,108,128...5,182,091
Ensembl chr 9:5,117,164...5,180,296

NTRK2

neurotrophic receptor tyrosine kinase 2

NCBI chr 1:74,447,927...74,777,910
Ensembl chr 1:74,449,060...74,777,032

SHC1

SHC adaptor protein 1

NCBI chr 7:42,501,829...42,509,613
Ensembl chr 7:42,500,185...42,508,276

TIAM1

TIAM Rac1 associated GEF 1

NCBI chr31:26,058,858...26,440,059
Ensembl chr31:25,932,697...26,202,756

c-Jun N-terminal kinases MAPK signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

DUSP1

dual specificity phosphatase 1

NCBI chr 4:39,588,833...39,591,065
Ensembl chr 4:39,588,339...39,590,514

DUSP10

dual specificity phosphatase 10

NCBI chr38:16,196,354...16,233,640
Ensembl chr38:16,196,635...16,231,315

DUSP16

dual specificity phosphatase 16

NCBI chr27:33,728,209...33,831,258
Ensembl chr27:33,789,557...33,832,075

DUSP19

dual specificity phosphatase 19

NCBI chr36:26,095,436...26,111,700
Ensembl chr36:26,095,463...26,111,774

DUSP8

dual specificity phosphatase 8

NCBI chr18:45,791,878...45,809,996
Ensembl chr18:45,794,330...45,809,996

LOC403934

cell division cycle 42

ISO

RGD

PMID:8910292 PMID:9305638

RGD:2293876 RGD:2293879

NCBI chr 2:77,153,276...77,169,947
Ensembl chr 2:77,153,095...77,199,211

MAP2K4

mitogen-activated protein kinase kinase 4

ISO

RGD

PMID:10051439 PMID:17064355 PMID:17306896

RGD:2293875 RGD:2298561 RGD:2298577

NCBI chr 5:36,142,610...36,243,673
Ensembl chr 5:36,118,388...36,241,296

MAP2K7

mitogen-activated protein kinase kinase 7

ISO

RGD

PMID:10051439 PMID:15680699 PMID:17064355 PMID:17306896

RGD:2293875 RGD:2298561 RGD:2298567 RGD:2298577

NCBI chr20:52,594,450...52,604,236
Ensembl chr20:52,594,536...52,602,150

MAP3K1

mitogen-activated protein kinase kinase kinase 1

ISO

RGD

PMID:9305638 PMID:17306896

RGD:2293875 RGD:2293879

NCBI chr 2:43,918,210...43,996,817
Ensembl chr 2:43,917,604...43,995,209

MAP3K10

mitogen-activated protein kinase kinase kinase 10

NCBI chr 1:113,422,239...113,435,979
Ensembl chr 1:113,422,518...113,428,688

MAP3K11

mitogen-activated protein kinase kinase kinase 11

ISO

RGD

PMID:8910292 PMID:15680699 PMID:17064355 PMID:17306896

RGD:2293875 RGD:2293876 RGD:2298567 RGD:2298577

NCBI chr18:51,593,641...51,609,245
Ensembl chr18:51,594,274...51,608,696

MAP3K12

mitogen-activated protein kinase kinase kinase 12

NCBI chr27:1,721,484...1,736,204
Ensembl chr27:1,726,310...1,734,955

MAP3K13

mitogen-activated protein kinase kinase kinase 13

NCBI chr34:18,081,158...18,252,800
Ensembl chr34:18,083,595...18,247,367

MAP3K2

mitogen-activated protein kinase kinase kinase 2

ISO

RGD

PMID:9305638 PMID:17306896

RGD:2293875 RGD:2293879

NCBI chr19:23,210,106...23,303,426
Ensembl chr19:23,210,714...23,294,586

MAP3K20

mitogen-activated protein kinase kinase kinase 20

NCBI chr36:17,353,829...17,515,247
Ensembl chr36:17,341,300...17,514,869

MAP3K21

mitogen-activated protein kinase kinase kinase 21

NCBI chr 4:6,339,146...6,391,333
Ensembl chr 4:6,341,540...6,391,364

MAP3K3

mitogen-activated protein kinase kinase kinase 3

ISO

RGD

PMID:9305638 PMID:17306896

RGD:2293875 RGD:2293879

NCBI chr 9:11,612,527...11,678,407
Ensembl chr 9:11,612,994...11,675,838

MAP3K4

mitogen-activated protein kinase kinase kinase 4

ISO

RGD

PMID:9305638 PMID:17306896

RGD:2293875 RGD:2293879

NCBI chr 1:49,590,615...49,702,289
Ensembl chr 1:49,548,274...49,702,289

MAP3K5

mitogen-activated protein kinase kinase kinase 5

ISO

RGD

PMID:12215209 PMID:17306896

RGD:2293875 RGD:2296020

NCBI chr 1:29,107,813...29,306,437
Ensembl chr 1:29,108,591...29,306,503

MAP3K7

mitogen-activated protein kinase kinase kinase 7

NCBI chr12:49,669,849...49,740,039
Ensembl chr12:49,672,389...49,739,850

MAP3K9

mitogen-activated protein kinase kinase kinase 9

NCBI chr 8:44,435,714...44,509,528
Ensembl chr 8:44,440,692...44,509,925

MAPK10

mitogen-activated protein kinase 10

ISO

RGD

PMID:10051439 PMID:15680699 PMID:17306896

RGD:2293875 RGD:2298561 RGD:2298567

NCBI chr32:9,584,437...9,889,118
Ensembl chr32:9,575,492...9,884,325

MAPK8

mitogen-activated protein kinase 8

ISO

RGD

PMID:10051439 PMID:17064355 PMID:17306896

RGD:2293875 RGD:2298561 RGD:2298577

NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401

MAPK8IP1

mitogen-activated protein kinase 8 interacting protein 1

ISO

RGD

PMID:15816852 PMID:17726577

RGD:1579811 RGD:2293880

NCBI chr18:43,517,186...43,522,603
Ensembl chr18:43,517,677...43,526,379

MAPK8IP2

mitogen-activated protein kinase 8 interacting protein 2

NCBI chr10:16,702,623...16,712,426
Ensembl chr10:16,702,621...16,712,278

MAPK8IP3

mitogen-activated protein kinase 8 interacting protein 3

NCBI chr 6:39,132,746...39,179,427
Ensembl chr 6:39,133,965...39,179,505

MAPK9

mitogen-activated protein kinase 9

ISO

RGD

PMID:10051439 PMID:17064355 PMID:17306896

RGD:2293875 RGD:2298561 RGD:2298577

NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119

RAC1

Rac family small GTPase 1

ISO

RGD

PMID:8910292 PMID:9305638

RGD:2293876 RGD:2293879

NCBI chr 6:11,726,259...11,758,532
Ensembl chr 6:11,655,494...11,757,216

RAPGEF1

Rap guanine nucleotide exchange factor 1

NCBI chr 9:52,429,204...52,566,775
Ensembl chr 9:52,450,597...52,563,778

SPP1

secreted phosphoprotein 1

NCBI chr32:11,354,070...11,362,325
Ensembl chr32:11,353,953...11,362,069

TRAF2

TNF receptor associated factor 2

NCBI chr 9:48,688,071...48,713,936
Ensembl chr 9:48,689,331...48,703,633

C-type natriuretic peptide signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

NPPC

natriuretic peptide C

ISO

RGD

PMID:15337698 PMID:16537417

RGD:1580149 RGD:1601488

NCBI chr25:43,714,545...43,718,969
Ensembl chr25:43,717,939...43,718,996

NPR2

natriuretic peptide receptor 2

NCBI chr11:52,283,680...52,339,247
Ensembl chr11:52,321,590...52,339,249

NPR3

natriuretic peptide receptor 3

NCBI chr 4:74,794,553...74,863,344
Ensembl chr 4:74,799,857...74,862,969

cadherin mediated signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

cadherin 2

NCBI chr 7:60,736,760...60,950,477
Ensembl chr 7:60,736,760...60,951,034

calcineurin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

NFATC2

nuclear factor of activated T cells 2

NCBI chr24:37,606,977...37,734,813
Ensembl chr24:37,609,561...37,771,132

NFATC3

nuclear factor of activated T cells 3

NCBI chr 5:81,294,656...81,434,256
Ensembl chr 5:81,296,214...81,434,250

NFATC4

nuclear factor of activated T cells 4

NCBI chr 8:4,337,098...4,346,409
Ensembl chr 8:4,336,450...4,346,100

PPP3CA

protein phosphatase 3 catalytic subunit alpha

NCBI chr32:22,688,141...22,996,693
Ensembl chr32:22,688,143...22,996,688

PPP3CB

protein phosphatase 3 catalytic subunit beta

NCBI chr 4:23,976,023...24,028,139
Ensembl chr 4:23,977,317...24,028,153

PPP3CC

protein phosphatase 3 catalytic subunit gamma

NCBI chr25:34,732,268...34,839,743
Ensembl chr25:34,725,226...34,838,994

PPP3R1

protein phosphatase 3 regulatory subunit B, alpha

NCBI chr10:67,242,552...67,308,469
Ensembl chr10:67,244,329...67,275,487

PPP3R2

protein phosphatase 3 regulatory subunit B, beta

NCBI chr11:58,295,237...58,295,942

RCAN1

regulator of calcineurin 1

NCBI chr31:29,908,046...30,002,412
Ensembl chr31:29,909,388...30,002,418

calcium signaling pathway via the calcium-sensing receptor

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ARRB1

arrestin beta 1

ISO

RGD

PMID:15637145 PMID:22192592

RGD:7207059 RGD:7207060

NCBI chr21:23,261,020...23,304,448
Ensembl chr21:23,235,711...23,297,786

ARRB2

arrestin beta 2

ISO

RGD

PMID:15637145 PMID:22192592

RGD:7207059 RGD:7207060

NCBI chr 5:31,831,208...31,838,875
Ensembl chr 5:31,829,864...31,839,454

CASR

calcium sensing receptor

ISO

RGD

PMID:12239094 PMID:15637145 PMID:22192592

RGD:7207059 RGD:7207060 RGD:7207227

NCBI chr33:25,340,822...25,432,814
Ensembl chr33:25,405,846...25,432,559

filamin A

NCBI chr X:122,058,303...122,083,467
Ensembl chr X:122,061,455...122,083,203

GRK2

G protein-coupled receptor kinase 2

NCBI chr18:50,148,566...50,167,422
Ensembl chr18:50,148,598...50,167,428

GRK3

G protein-coupled receptor kinase 3

NCBI chr26:19,385,059...19,512,528
Ensembl chr26:19,385,058...19,516,077

GRK4

G protein-coupled receptor kinase 4

NCBI chr 3:61,233,066...61,331,094
Ensembl chr 3:61,079,904...61,330,290

RGS12

regulator of G protein signaling 12

NCBI chr 3:60,917,033...61,011,812
Ensembl chr 3:60,917,072...61,009,131

RGS2

regulator of G protein signaling 2

NCBI chr38:6,200,237...6,203,491
Ensembl chr38:6,200,657...6,203,494

RGS4

regulator of G protein signaling 4

NCBI chr38:19,771,454...19,778,917
Ensembl chr38:19,771,441...19,779,190

RGS5

regulator of G protein signaling 5

NCBI chr38:19,683,396...19,730,514
Ensembl chr38:19,683,485...19,725,778

RHOA

ras homolog family member A

NCBI chr20:39,824,552...39,888,089
Ensembl chr20:39,824,575...39,887,215

calcium/calcium-mediated signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ATP2A1

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

NCBI chr 6:18,384,981...18,400,038
Ensembl chr 6:18,385,007...18,400,036

ATP2A2

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388

ATP2A3

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

NCBI chr 9:47,694,494...47,727,017
Ensembl chr 9:47,695,809...47,727,778

ATP2B1

ATPase plasma membrane Ca2+ transporting 1

NCBI chr15:30,547,009...30,674,094
Ensembl chr15:30,547,015...30,616,429

ATP2B2

ATPase plasma membrane Ca2+ transporting 2

NCBI chr20:7,665,468...8,037,407
Ensembl chr20:7,749,807...8,034,474

ATP2B3

ATPase plasma membrane Ca2+ transporting 3

NCBI chr X:121,355,217...121,405,245
Ensembl chr X:121,361,239...121,403,609

ATP2B4

ATPase plasma membrane Ca2+ transporting 4

NCBI chr38:321,246...420,262
Ensembl chr38:366,656...416,952

ATP2C1

ATPase secretory pathway Ca2+ transporting 1

NCBI chr23:28,097,831...28,233,675
Ensembl chr23:28,066,639...28,235,215

ATP2C2

ATPase secretory pathway Ca2+ transporting 2

NCBI chr 5:67,986,120...68,046,391
Ensembl chr 5:67,986,355...68,046,272

CABP1

calcium binding protein 1

NCBI chr26:16,492,484...16,523,265

CABP2

calcium binding protein 2

NCBI chr18:49,960,656...49,963,889
Ensembl chr18:49,959,544...49,964,268

CABP4

calcium binding protein 4

NCBI chr18:50,014,698...50,017,854
Ensembl chr18:50,014,698...50,017,854

CACNA1A

calcium voltage-gated channel subunit alpha1 A

NCBI chr20:48,747,087...49,036,627
Ensembl chr20:48,821,025...49,036,032

CACNA1B

calcium voltage-gated channel subunit alpha1 B

NCBI chr 9:47,813,625...48,009,532
Ensembl chr 9:47,816,393...48,009,406

CACNA1C

calcium voltage-gated channel subunit alpha1 C

NCBI chr27:44,007,363...44,748,251
Ensembl chr27:44,008,020...44,746,429

CACNA1D

calcium voltage-gated channel subunit alpha1 D

NCBI chr20:36,189,986...36,488,460
Ensembl chr20:36,191,810...36,613,686

CACNA1E

calcium voltage-gated channel subunit alpha1 E

NCBI chr 7:14,892,165...15,267,418
Ensembl chr 7:14,707,801...15,267,422

CACNA1F

calcium voltage-gated channel subunit alpha1 F

NCBI chr X:42,302,971...42,327,787
Ensembl chr X:42,303,158...42,326,774

CACNA1G

calcium voltage-gated channel subunit alpha1 G

NCBI chr 9:26,481,148...26,544,511
Ensembl chr 9:26,481,652...26,544,845

CACNA1H

calcium voltage-gated channel subunit alpha1 H

NCBI chr 6:39,510,129...39,533,129
Ensembl chr 6:39,510,121...39,533,753

CACNA1I

calcium voltage-gated channel subunit alpha1 I

NCBI chr10:25,381,446...25,493,680
Ensembl chr10:25,380,943...25,482,852

CACNA1S

calcium voltage-gated channel subunit alpha1 S

NCBI chr 7:2,108,716...2,172,246
Ensembl chr 7:2,108,455...2,303,220

CACNB1

calcium voltage-gated channel auxiliary subunit beta 1

NCBI chr 9:23,182,407...23,197,035
Ensembl chr 9:23,180,554...23,195,673

CACNB2

calcium voltage-gated channel auxiliary subunit beta 2

NCBI chr 2:18,537,100...18,787,728
Ensembl chr 2:18,538,620...18,902,286

CACNB3

calcium voltage-gated channel auxiliary subunit beta 3

NCBI chr27:5,705,587...5,714,620
Ensembl chr27:5,706,064...5,717,647

CACNB4

calcium voltage-gated channel auxiliary subunit beta 4

NCBI chr19:52,987,170...53,116,410
Ensembl chr19:52,993,618...53,116,140
Ensembl chr19:52,993,618...53,116,140

calbindin 1

NCBI chr29:35,551,836...35,572,985
Ensembl chr29:35,552,436...35,572,925

calbindin 2

NCBI chr 5:77,178,158...77,205,663
Ensembl chr 5:77,177,951...77,205,671

CALM1

calmodulin 1

ISO

RGD

PMID:10884684 PMID:18083096

RGD:7204676 RGD:7204677

NCBI chr 8:61,398,231...61,408,874
Ensembl chr 8:61,398,244...61,406,195

CALM2

calmodulin 2

ISO

RGD

PMID:10884684 PMID:18083096

RGD:7204676 RGD:7204677

NCBI chr10:49,299,698...49,314,533
Ensembl chr10:49,299,897...49,314,457

CALM3

calmodulin 3

ISO

RGD

PMID:10884684 PMID:18083096

RGD:7204676 RGD:7204677

NCBI chr 1:109,284,729...109,294,491
Ensembl chr 1:109,286,155...109,294,391

calreticulin

NCBI chr20:49,251,390...49,255,291
Ensembl chr20:49,251,777...49,255,245

calsequestrin 1

NCBI chr38:22,012,060...22,020,430
Ensembl chr38:22,011,060...22,020,383

calsequestrin 2

NCBI chr17:53,233,966...53,299,093
Ensembl chr17:53,224,438...53,299,708

CNGA1

cyclic nucleotide gated channel subunit alpha 1

NCBI chr13:43,831,159...43,864,276
Ensembl chr13:43,831,163...43,864,276

CNGA2

cyclic nucleotide gated channel subunit alpha 2

NCBI chr X:119,695,898...119,702,791
Ensembl chr X:119,695,898...119,702,446

CNGA3

cyclic nucleotide gated channel subunit alpha 3

NCBI chr10:44,232,716...44,278,555
Ensembl chr10:44,234,004...44,260,746

CNGA4

cyclic nucleotide gated channel subunit alpha 4

NCBI chr21:29,575,140...29,581,721
Ensembl chr21:29,575,578...29,580,616

CNGB1

cyclic nucleotide gated channel subunit beta 1

NCBI chr 2:58,574,552...58,641,631
Ensembl chr 2:58,574,552...58,640,812

CNGB3

cyclic nucleotide gated channel subunit beta 3

NCBI chr29:32,744,946...32,992,715
Ensembl chr29:32,749,389...32,893,077

GUCA1A

guanylate cyclase activator 1A

NCBI chr12:10,786,284...10,795,974
Ensembl chr12:10,788,424...10,795,442

GUCA1B

guanylate cyclase activator 1B

NCBI chr12:10,796,961...10,806,796
Ensembl chr12:10,797,921...10,834,237

GUCA2B

guanylate cyclase activator 2B

NCBI chr15:1,094,283...1,096,605
Ensembl chr15:1,094,276...1,096,688

ITPR1

inositol 1,4,5-trisphosphate receptor type 1

NCBI chr20:12,746,171...13,065,256
Ensembl chr20:12,747,315...13,064,198

ITPR2

inositol 1,4,5-trisphosphate receptor type 2

NCBI chr27:20,806,670...21,278,638
Ensembl chr27:20,805,842...21,350,083

ITPR3

inositol 1,4,5-trisphosphate receptor type 3

NCBI chr12:2,970,613...3,050,254
Ensembl chr12:2,805,187...3,048,938

KCNIP1

potassium voltage-gated channel interacting protein 1

NCBI chr 4:41,220,128...41,566,841
Ensembl chr 4:41,223,369...41,431,510

KCNIP2

potassium voltage-gated channel interacting protein 2

NCBI chr28:14,409,526...14,425,641
Ensembl chr28:14,409,526...14,425,641

KCNIP3

potassium voltage-gated channel interacting protein 3

NCBI chr17:34,725,433...34,808,429

KCNIP4

potassium voltage-gated channel interacting protein 4

NCBI chr 3:88,013,222...88,896,093
Ensembl chr 3:87,771,875...88,894,884

KCNN1

potassium calcium-activated channel subfamily N member 1

NCBI chr20:44,939,619...44,971,923
Ensembl chr20:44,939,603...44,969,020

KCNN2

potassium calcium-activated channel subfamily N member 2

NCBI chr11:4,279,362...4,423,080
Ensembl chr11:4,154,746...4,423,078

KCNN3

potassium calcium-activated channel subfamily N member 3

NCBI chr 7:42,562,500...42,704,862
Ensembl chr 7:42,572,432...42,698,047

KCNN4

potassium calcium-activated channel subfamily N member 4

NCBI chr 1:111,391,464...111,407,612
Ensembl chr 1:111,391,159...111,407,701

MCOLN1

mucolipin TRP cation channel 1

NCBI chr20:52,318,411...52,327,389
Ensembl chr20:52,318,408...52,348,963

MCU

mitochondrial calcium uniporter

NCBI chr 4:23,309,376...23,508,480
Ensembl chr 4:23,309,391...23,506,586

NCS1

neuronal calcium sensor 1

NCBI chr 9:53,661,361...53,676,925
Ensembl chr 9:53,672,910...53,676,910

ORAI1

ORAI calcium release-activated calcium modulator 1

NCBI chr26:7,584,276...7,599,667
Ensembl chr26:7,584,880...7,599,401

ORAI2

ORAI calcium release-activated calcium modulator 2

NCBI chr 6:7,725,901...7,738,477
Ensembl chr 6:7,728,505...7,737,962

ORAI3

ORAI calcium release-activated calcium modulator 3

NCBI chr 6:17,248,900...17,253,935
Ensembl chr 6:17,248,884...17,274,850

parvalbumin

NCBI chr10:27,655,896...27,674,309
Ensembl chr10:27,655,905...27,707,332

recoverin

NCBI chr 5:34,323,580...34,330,667
Ensembl chr 5:34,323,576...34,330,667

ryanodine receptor 1

NCBI chr 1:114,461,350...114,579,577
Ensembl chr 1:114,461,348...114,579,493

ryanodine receptor 2

NCBI chr 4:2,371,868...2,908,132
Ensembl chr 4:2,373,114...2,907,875

ryanodine receptor 3

NCBI chr30:1,179,575...1,533,352
Ensembl chr30:1,180,359...1,533,619

S100A1

S100 calcium binding protein A1

ISO

RGD

PMID:16129693 PMID:17964289

RGD:1579960 RGD:7204682

NCBI chr 7:43,428,819...43,432,637
Ensembl chr 7:43,428,820...43,433,459

S100A4

S100 calcium binding protein A4

NCBI chr 7:43,494,007...43,496,021

S100B

S100 calcium binding protein B

NCBI chr31:39,783,990...39,788,289
Ensembl chr31:39,784,506...39,788,183

S100G

S100 calcium binding protein G

NCBI chr X:12,808,234...12,813,696
Ensembl chr X:12,808,718...12,812,972

SLC24A1

solute carrier family 24 member 1

NCBI chr30:29,967,762...29,996,762
Ensembl chr30:29,967,762...29,995,005

SLC24A2

solute carrier family 24 member 2

NCBI chr11:39,273,285...39,521,223
Ensembl chr11:39,278,370...39,519,222

SLC24A3

solute carrier family 24 member 3

NCBI chr24:3,593,562...4,014,366
Ensembl chr24:3,593,513...3,784,467

SLC24A4

solute carrier family 24 member 4

NCBI chr 8:1,570,833...1,685,135
Ensembl chr 8:1,517,560...1,680,208

SLC24A5

solute carrier family 24 member 5

NCBI chr30:14,372,019...14,400,262
Ensembl chr30:14,371,778...14,400,152

SLC8A1

solute carrier family 8 member A1

NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700

SLC8A2

solute carrier family 8 member A2

NCBI chr 1:108,544,825...108,575,894
Ensembl chr 1:108,544,509...108,575,891

SLC8A3

solute carrier family 8 member A3

NCBI chr 8:43,780,363...43,926,142
Ensembl chr 8:43,781,120...43,926,343

SLC8B1

solute carrier family 8 member B1

NCBI chr26:10,662,491...10,688,182
Ensembl chr26:10,662,208...10,687,629

STIM1

stromal interaction molecule 1

NCBI chr21:26,394,592...26,594,764
Ensembl chr21:26,394,811...26,593,375

STIM2

stromal interaction molecule 2

NCBI chr 3:83,560,690...83,703,978
Ensembl chr 3:83,564,108...83,724,520

SYT1

synaptotagmin 1

ISO

RGD

PMID:11751925 PMID:15534041

RGD:2311146 RGD:7204679

NCBI chr15:21,629,061...22,042,734
Ensembl chr15:21,834,763...22,042,732

SYT7

synaptotagmin 7

ISO

RGD

PMID:15534041 PMID:18713958

RGD:2311148 RGD:7204679

NCBI chr18:54,863,072...54,926,121
Ensembl chr18:54,861,754...54,921,367

SYT9

synaptotagmin 9

ISO

RGD

PMID:11751925 PMID:18713958

RGD:2311146 RGD:2311148

NCBI chr21:30,985,059...31,123,986
Ensembl chr21:30,986,521...31,162,414

TNNC1

troponin C1, slow skeletal and cardiac type

NCBI chr20:37,313,983...37,317,288
Ensembl chr20:37,311,966...37,317,321

TNNC2

troponin C2, fast skeletal type

NCBI chr24:33,136,644...33,139,289
Ensembl chr24:33,128,290...33,163,050

TPCN1

two pore segment channel 1

NCBI chr26:10,599,898...10,662,269
Ensembl chr26:10,599,780...10,660,767

TPCN2

two pore segment channel 2

NCBI chr18:48,956,833...48,984,499
Ensembl chr18:48,957,249...48,984,564

TRPV5

transient receptor potential cation channel subfamily V member 5

NCBI chr16:6,647,070...6,678,080
Ensembl chr16:6,650,574...6,676,963

TRPV6

transient receptor potential cation channel subfamily V member 6

NCBI chr16:6,691,521...6,706,205
Ensembl chr16:6,691,254...6,706,207

calcium/calmodulin dependent kinase 2 signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CACNA1C

calcium voltage-gated channel subunit alpha1 C

NCBI chr27:44,007,363...44,748,251
Ensembl chr27:44,008,020...44,746,429

CACNB2

calcium voltage-gated channel auxiliary subunit beta 2

NCBI chr 2:18,537,100...18,787,728
Ensembl chr 2:18,538,620...18,902,286

CACNG2

calcium voltage-gated channel auxiliary subunit gamma 2

NCBI chr10:27,750,314...27,862,646
Ensembl chr10:27,750,935...27,862,885

CALM1

calmodulin 1

ISO

RGD

PMID:22717267 PMID:23091085

RGD:7240705 RGD:7240708

NCBI chr 8:61,398,231...61,408,874
Ensembl chr 8:61,398,244...61,406,195

CALM2

calmodulin 2

ISO

RGD

PMID:22717267 PMID:23091085

RGD:7240705 RGD:7240708

NCBI chr10:49,299,698...49,314,533
Ensembl chr10:49,299,897...49,314,457

CALM3

calmodulin 3

ISO

RGD

PMID:22717267 PMID:23091085

RGD:7240705 RGD:7240708

NCBI chr 1:109,284,729...109,294,491
Ensembl chr 1:109,286,155...109,294,391

CAMK2A

calcium/calmodulin dependent protein kinase II alpha

ISO

RGD

PMID:22334212 PMID:22717267

RGD:7240704 RGD:7240705

NCBI chr 4:58,800,818...58,865,830
Ensembl chr 4:58,800,813...58,865,830 <

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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PATHWAY ONTOLOGY - ANNOTATIONS