signaling pathway - Ontology Report

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PATHWAY ONTOLOGY - ANNOTATIONS	{{ watchLinkText }}
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:	signaling pathway	go back to main search page
Accession:	PW:0000003	browse the term
Definition:	The pathways where a signal - hormone, neurotransmitter, growth factor, peptide, any molecule - triggers one or multiple cascades of events. This involves a number of molecules, including receptors, proteins, ligands, messengers, any participating molecule. A signaling pathway may be upstream or downstream of other signaling pathways. Signaling pathways control a very broad spectrum of processes as well as pathways.
Comment:	The definition was compiled based on a number of definitions available in various dictionaries.
Synonyms:	related_synonym:	Signal Transduction

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Rat (2646) Mouse (2512) Human (2505) Chinchilla (1890) Bonobo (1938) Dog (1936) Squirrel (1893) Pig (1929) Green Monkey (1930) Naked Mole-rat (1885) All
Genes (1938)

acetylcholine signaling pathway via muscarinic acetylcholine receptor

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACHE

acetylcholinesterase (Cartwright blood group)

NCBI chr 7:92,915,065...92,922,079
Ensembl chr 7:106,311,944...106,318,184

CHAT

choline O-acetyltransferase

NCBI chr10:44,574,925...44,629,618

GRK2

G protein-coupled receptor kinase 2

NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066

GRK5

G protein-coupled receptor kinase 5

NCBI chr10:115,776,236...116,026,221
Ensembl chr10:119,200,688...119,450,809

RGS2

regulator of G protein signaling 2

NCBI chr 1:168,273,112...168,276,348
Ensembl chr 1:172,566,701...172,569,955

RGS4

regulator of G protein signaling 4

NCBI chr 1:138,488,317...138,496,497
Ensembl chr 1:142,284,040...142,292,225

RGS6

regulator of G protein signaling 6

NCBI chr14:52,511,846...53,146,872
Ensembl chr14:71,409,701...72,008,988

SLC18A3

solute carrier family 18 member A3

NCBI chr10:44,630,006...44,632,419

SLC5A7

solute carrier family 5 member 7

NCBI chr2A:93,917,086...93,944,308
Ensembl chr2A:109,017,805...109,046,860

acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CHRM2

cholinergic receptor muscarinic 2

NCBI chr 7:128,827,089...128,978,496
Ensembl chr 7:141,466,396...141,467,796

CHRM4

cholinergic receptor muscarinic 4

NCBI chr11:46,342,384...46,350,366
Ensembl chr11:46,894,615...46,896,054

GNAI1

G protein subunit alpha i1

NCBI chr 7:72,102,937...72,188,124
Ensembl chr 7:85,812,249...85,851,283

GNAI2

G protein subunit alpha i2

NCBI chr 3:50,154,731...50,187,948
Ensembl chr 3:51,398,981...51,421,988

acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CHRM1

cholinergic receptor muscarinic 1

NCBI chr11:58,261,476...58,274,685
Ensembl chr11:61,614,818...61,616,200

CHRM3

cholinergic receptor muscarinic 3

NCBI chr 1:214,931,514...215,452,739

CHRM5

cholinergic receptor muscarinic 5

NCBI chr15:12,478,656...12,575,512
Ensembl chr15:31,406,198...31,407,796

GNA11

G protein subunit alpha 11

NCBI chr19:2,120,398...2,149,161
Ensembl chr19:3,074,483...3,102,124

GNA14

G protein subunit alpha 14

NCBI chr 9:47,196,338...47,423,388

LOC100986730

guanine nucleotide-binding protein G(q) subunit alpha

NCBI chr 9:46,816,409...47,129,116
Ensembl chr 9:76,575,815...76,773,849

acetylcholine signaling pathway via nicotinic acetylcholine receptor

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACHE

acetylcholinesterase (Cartwright blood group)

NCBI chr 7:92,915,065...92,922,079
Ensembl chr 7:106,311,944...106,318,184

agrin

Ensembl chr 1:936,000...966,808

CHAT

choline O-acetyltransferase

NCBI chr10:44,574,925...44,629,618

CHRNA1

cholinergic receptor nicotinic alpha 1 subunit

ISO

RGD

PMID:19126755 PMID:23032192

RGD:8549508 RGD:8549510

NCBI chr2B:62,022,498...62,039,370
Ensembl chr2B:179,476,677...179,504,763

CHRNA10

cholinergic receptor nicotinic alpha 10 subunit

NCBI chr11:3,543,450...3,552,036
Ensembl chr11:3,651,580...3,656,780

CHRNA2

cholinergic receptor nicotinic alpha 2 subunit

NCBI chr 8:26,729,767...26,749,277
Ensembl chr 8:23,932,846...23,952,377

CHRNA3

cholinergic receptor nicotinic alpha 3 subunit

NCBI chr15:57,523,553...57,550,228
Ensembl chr15:76,487,710...76,512,044

CHRNA4

cholinergic receptor nicotinic alpha 4 subunit

NCBI chr20:59,730,759...59,748,678
Ensembl chr20:61,270,631...61,283,005

CHRNA5

cholinergic receptor nicotinic alpha 5 subunit

NCBI chr15:57,493,730...57,530,463
Ensembl chr15:76,455,165...76,486,376

CHRNA6

cholinergic receptor nicotinic alpha 6 subunit

NCBI chr 8:42,000,748...42,016,913
Ensembl chr 8:39,444,447...39,460,569

CHRNA7

cholinergic receptor nicotinic alpha 7 subunit

NCBI chr15:10,525,535...10,667,227
Ensembl chr15:29,565,885...29,705,194

CHRNA9

cholinergic receptor nicotinic alpha 9 subunit

NCBI chr 4:34,654,043...34,675,984
Ensembl chr 4:40,509,475...40,528,869

CHRNB1

cholinergic receptor nicotinic beta 1 subunit

ISO

RGD

PMID:19126755 PMID:23032192

RGD:8549508 RGD:8549510

NCBI chr17:7,479,056...7,490,314
Ensembl chr17:7,465,229...7,476,099

CHRNB2

cholinergic receptor nicotinic beta 2 subunit

NCBI chr 1:129,922,740...129,931,582
Ensembl chr 1:133,535,023...133,547,361

CHRNB3

cholinergic receptor nicotinic beta 3 subunit

NCBI chr 8:41,947,062...41,987,159
Ensembl chr 8:39,391,001...39,429,926

CHRNB4

cholinergic receptor nicotinic beta 4 subunit

NCBI chr15:57,552,697...57,570,828
Ensembl chr15:76,515,455...76,532,712

CHRND

cholinergic receptor nicotinic delta subunit

ISO

RGD

PMID:19126755 PMID:23032192

RGD:8549508 RGD:8549510

NCBI chr2B:119,757,722...119,768,254
Ensembl chr2B:238,676,495...238,686,987

CHRNG

cholinergic receptor nicotinic gamma subunit

ISO

RGD

PMID:19126755 PMID:23032192

RGD:8549508 RGD:8549510

NCBI chr2B:119,770,636...119,779,332
Ensembl chr2B:238,689,935...238,696,526

docking protein 7

NCBI chr 4:3,613,018...3,653,764
Ensembl chr 4:3,605,185...3,628,570

LOC100984737

acetylcholine receptor subunit epsilon

ISO

RGD

PMID:19126755 PMID:23032192

RGD:8549508 RGD:8549510

NCBI chr17:4,944,046...4,950,288
Ensembl chr17:4,932,862...4,937,963

LRP4

LDL receptor related protein 4

NCBI chr11:46,808,090...46,868,649
Ensembl chr11:47,366,321...47,411,105

MUSK

muscle associated receptor tyrosine kinase

NCBI chr 9:81,814,766...81,947,341
Ensembl chr 9:109,980,748...110,107,480

RAPSN

receptor associated protein of the synapse

NCBI chr11:47,387,324...47,398,579
Ensembl chr11:47,940,530...47,951,667

SLC18A3

solute carrier family 18 member A3

NCBI chr10:44,630,006...44,632,419

SLC5A7

solute carrier family 5 member 7

NCBI chr2A:93,917,086...93,944,308
Ensembl chr2A:109,017,805...109,046,860

activin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACVR1

activin A receptor type 1

ISO

PID
RGD

PMID:12770730

PID:200029 RGD:1559169

NCBI chr2B:44,994,175...45,133,490
Ensembl chr2B:162,234,823...162,297,805

ACVR1B

activin A receptor type 1B

NCBI chr12:36,765,655...36,811,355
Ensembl chr12:37,541,867...37,566,660

ACVR2A

activin A receptor type 2A

NCBI chr2B:11,933,683...12,020,287
Ensembl chr2B:152,253,826...152,288,385

ACVR2B

activin A receptor type 2B

NCBI chr 3:38,350,838...38,389,839
Ensembl chr 3:38,633,093...38,662,063

ACVRL1

activin A receptor like type 1

ISO

PID
RGD

PMID:12770730

PID:200029 RGD:1559169

NCBI chr12:36,839,869...36,856,351
Ensembl chr12:37,615,888...37,631,691

FKBP1A

FKBP prolyl isomerase 1A

ISO

PID

PID:200029

NCBI chr20:1,519,330...1,548,473

SMAD family member 2

NCBI chr18:41,213,001...41,309,902
Ensembl chr18:44,580,905...44,668,530

SMAD family member 3

NCBI chr15:46,013,764...46,143,126
Ensembl chr15:64,284,949...64,414,185

adenosine monophosphate-activated protein kinase (AMPK) signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CAB39

calcium binding protein 39

ISO

RGD

PMID:14511394 PMID:15509864

RGD:1600678 RGD:1600691

NCBI chr2B:117,965,688...118,074,063
Ensembl chr2B:236,809,549...236,870,646

calmodulin 1

NCBI chr14:71,015,099...71,026,322
Ensembl chr19:52,121,687...52,131,135

calmodulin 2

NCBI chr2A:47,274,722...47,290,861
Ensembl chr2A:48,204,518...48,220,697

calmodulin 3

NCBI chr19:43,593,069...43,602,550
Ensembl chr19:52,121,687...52,131,135

CAMKK1

calcium/calmodulin dependent protein kinase kinase 1

NCBI chr17:3,908,598...3,941,118
Ensembl chr17:3,900,458...3,930,010

CAMKK2

calcium/calmodulin dependent protein kinase kinase 2

NCBI chr12:118,835,862...118,896,918
Ensembl chr12:122,206,552...122,267,631

CPT1A

carnitine palmitoyltransferase 1A

NCBI chr11:63,841,028...63,928,242
Ensembl chr11:67,144,736...67,205,481

PPM1E

protein phosphatase, Mg2+/Mn2+ dependent 1E

NCBI chr17:52,832,291...53,057,157
Ensembl chr17:57,874,629...57,903,205

PPM1F

protein phosphatase, Mg2+/Mn2+ dependent 1F

NCBI chr22:4,039,032...4,072,165
Ensembl chr22:20,520,022...20,553,128

PPP1CA

protein phosphatase 1 catalytic subunit alpha

NCBI chr11:62,756,659...62,760,369
Ensembl chr11:66,068,007...66,071,611

PPP1CB

protein phosphatase 1 catalytic subunit beta

NCBI chr2A:28,758,176...28,809,561
Ensembl chr2A:28,862,083...28,889,401

PPP1R3D

protein phosphatase 1 regulatory subunit 3D

NCBI chr20:56,292,457...56,295,977

PPP2CA

protein phosphatase 2 catalytic subunit alpha

NCBI chr 5:129,599,606...129,629,312
Ensembl chr 5:135,751,958...135,765,786

PRKAA1

protein kinase AMP-activated catalytic subunit alpha 1

ISO

RGD

PMID:12829246 PMID:14511394 PMID:15509864

RGD:1600678 RGD:1600679 RGD:1600691

NCBI chr 5:69,581,748...69,620,721
Ensembl chr 5:74,627,830...74,666,505

PRKAA2

protein kinase AMP-activated catalytic subunit alpha 2

ISO

RGD

PMID:12829246 PMID:14511394 PMID:15509864

RGD:1600678 RGD:1600679 RGD:1600691

NCBI chr 1:55,928,577...55,998,628
Ensembl chr 1:57,664,237...57,702,227

PRKAB1

protein kinase AMP-activated non-catalytic subunit beta 1

ISO

RGD

PMID:12829246 PMID:15509864

RGD:1600678 RGD:1600679

NCBI chr12:117,246,691...117,260,465
Ensembl chr12:120,624,004...120,637,585

PRKAB2

protein kinase AMP-activated non-catalytic subunit beta 2

ISO

RGD

PMID:12829246 PMID:15509864

RGD:1600678 RGD:1600679

NCBI chr 1:122,577,308...122,595,083
Ensembl chr 1:112,934,877...112,952,364

PRKAG1

protein kinase AMP-activated non-catalytic subunit gamma 1

ISO

RGD

PMID:12829246 PMID:14511394 PMID:15509864

RGD:1600678 RGD:1600679 RGD:1600691

NCBI chr12:39,731,899...39,748,620
Ensembl chr12:40,611,532...40,628,263

PRKAG2

protein kinase AMP-activated non-catalytic subunit gamma 2

ISO

RGD

PMID:12829246 PMID:15509864

RGD:1600678 RGD:1600679

NCBI chr 7:143,143,556...143,463,492
Ensembl chr 7:155,293,748...155,610,078

PRKAG3

protein kinase AMP-activated non-catalytic subunit gamma 3

ISO

RGD

PMID:12829246 PMID:15509864

RGD:1600678 RGD:1600679

NCBI chr2B:106,085,299...106,139,298
Ensembl chr2B:224,679,831...224,687,705

STK11

serine/threonine kinase 11

ISO

RGD

PMID:14511394 PMID:15509864

RGD:1600678 RGD:1600691

Ensembl chr19:1,188,537...1,210,677

STRADA

STE20 related adaptor alpha

ISO

RGD

PMID:14511394 PMID:15509864

RGD:1600678 RGD:1600691

NCBI chr17:57,783,114...57,822,056
Ensembl chr17:62,929,065...62,967,021

TSC1

TSC complex subunit 1

NCBI chr 9:104,007,708...104,060,938
Ensembl chr 9:132,638,003...132,675,759

adenosine signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ADCY2

adenylate cyclase 2

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 5:7,718,581...8,154,006
Ensembl chr 5:7,540,790...7,975,853

ADORA2A

adenosine A2a receptor

ISO

SMPDB

SMP:00320

NCBI chr22:5,233,876...5,248,622
Ensembl chr22:22,104,253...22,114,189

ADORA2B

adenosine A2b receptor

ISO

SMPDB

SMP:00321

NCBI chr17:34,849,466...34,880,088

AKT1

AKT serine/threonine kinase 1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756

ARHGEF7

Rho guanine nucleotide exchange factor 7

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr13:92,246,107...92,436,173
Ensembl chr13:111,427,905...111,545,413

ATF2

activating transcription factor 2

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr2B:62,348,245...62,444,428
Ensembl chr2B:179,799,365...179,895,007

BAD

BCL2 associated agonist of cell death

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr11:59,626,981...59,641,824
Ensembl chr11:62,971,808...62,986,257

BRAF

B-Raf proto-oncogene, serine/threonine kinase

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 7:132,651,908...132,855,422
Ensembl chr 7:145,138,510...145,327,115

CDC42

cell division cycle 42

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 1:21,245,970...21,286,210

CHUK

component of inhibitor of nuclear factor kappa B kinase complex

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr10:96,794,228...96,835,449
Ensembl chr10:100,280,490...100,316,918

CREB1

cAMP responsive element binding protein 1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr2B:94,762,796...94,836,304
Ensembl chr2B:212,891,261...212,958,130

ELK1

ETS transcription factor ELK1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr X:40,071,433...40,086,518
Ensembl chr X:47,967,492...47,982,579

GNAS

GNAS complex locus

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr20:55,190,607...55,262,245

GNB1

G protein subunit beta 1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 1:490,415...596,826
Ensembl chr 1:1,647,340...1,701,614

GNG12

G protein subunit gamma 12

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 1:66,941,315...67,071,442
Ensembl chr 1:68,901,264...68,903,487

HRAS

HRas proto-oncogene, GTPase

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr11:537,488...540,810
Ensembl chr11:568,305...571,078

IKBKB

inhibitor of nuclear factor kappa B kinase subunit beta

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 8:41,515,613...41,576,229
Ensembl chr 8:38,960,594...39,020,971

JUN

Jun proto-oncogene, AP-1 transcription factor subunit

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 1:58,042,794...58,045,536

MAP2K2

mitogen-activated protein kinase kinase 2

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr19:3,114,445...3,148,619
Ensembl chr19:4,064,626...4,097,933

MAP2K6

mitogen-activated protein kinase kinase 6

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr17:63,342,720...63,483,926
Ensembl chr17:68,730,011...68,870,454

MAP2K7

mitogen-activated protein kinase kinase 7

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr19:7,205,124...7,215,776
Ensembl chr19:8,057,598...8,066,512

MAP3K1

mitogen-activated protein kinase kinase kinase 1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 5:57,116,405...57,197,017
Ensembl chr 5:58,745,579...58,826,959

MAP3K4

mitogen-activated protein kinase kinase kinase 4

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 6:158,937,424...159,062,550
Ensembl chr 6:163,948,122...164,073,264

MAPK1

mitogen-activated protein kinase 1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335

MAPK11

mitogen-activated protein kinase 11

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr22:30,492,664...30,499,456
Ensembl chr22:49,492,693...49,495,732

MAPK8

mitogen-activated protein kinase 8

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr10:45,806,748...45,936,362

NFKB1

nuclear factor kappa B subunit 1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 4:94,925,048...95,040,849
Ensembl chr 4:105,589,062...105,704,098

NFKB2

nuclear factor kappa B subunit 2

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr10:98,997,604...99,006,407
Ensembl chr10:102,463,503...102,471,907

NFKBIA

NFKB inhibitor alpha

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr14:16,155,331...16,158,588

PAK1

p21 (RAC1) activated kinase 1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr11:72,372,577...72,524,817
Ensembl chr11:76,015,998...76,104,197

PARD6A

par-6 family cell polarity regulator alpha

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr16:48,004,822...48,006,656
Ensembl chr16:67,394,252...67,395,991

PDPK1

3-phosphoinositide dependent protein kinase 1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr16:1,394,447...1,463,735

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 3:176,182,765...176,272,024
Ensembl chr 3:184,355,785...184,441,977

PRKACB

protein kinase cAMP-activated catalytic subunit beta

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 1:116,625,640...116,786,396
Ensembl chr 1:85,487,681...85,644,253

PRKCZ

protein kinase C zeta

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 1:763,942...901,531
Ensembl chr 1:1,920,219...2,045,855

RAP1A

RAP1A, member of RAS oncogene family

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 1:114,279,255...114,376,977
Ensembl chr 1:125,971,598...125,994,813

RAPGEF2

Rap guanine nucleotide exchange factor 2

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 4:151,419,402...151,680,769
Ensembl chr 4:163,316,396...163,487,495

RAPGEF3

Rap guanine nucleotide exchange factor 3

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr12:40,974,756...40,999,471
Ensembl chr12:41,848,785...41,873,252

RPS6KA1

ribosomal protein S6 kinase A1

ISO

SMPDB

SMP:00320 SMP:00321

NCBI chr 1:25,792,428...25,837,950
Ensembl chr 1:26,856,057...26,900,532

adiponectin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ADIPOQ

adiponectin, C1Q and collagen domain containing

NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885

ADIPOR1

adiponectin receptor 1

NCBI chr 1:178,542,496...178,560,055
Ensembl chr 1:182,837,589...182,854,782

ADIPOR2

adiponectin receptor 2

ISO

RGD

PMID:16823476 PMID:18755807 PMID:24797033 PMID:27220557

RGD:1642395 RGD:25824939 RGD:25824940 RGD:25824943

NCBI chr12:1,772,426...1,902,070
Ensembl chr12:1,817,620...1,852,251

aldosterone signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CASP8AP2

caspase 8 associated protein 2

NCBI chr 6:87,707,152...87,754,836
Ensembl chr 6:90,996,127...91,023,757

CREB binding protein

NCBI chr16:2,645,445...2,800,975
Ensembl chr16:3,820,519...3,974,206

DAXX

death domain associated protein

NCBI chr 6:32,890,846...32,895,307
Ensembl chr 6:34,004,543...34,008,717

DExH-box helicase 9

NCBI chr 1:158,355,472...158,404,178
Ensembl chr 1:162,006,822...162,055,833

ELL

elongation factor for RNA polymerase II

NCBI chr19:17,923,035...17,999,842
Ensembl chr19:18,894,054...18,969,923

FAF1

Fas associated factor 1

NCBI chr 1:49,679,198...50,207,129
Ensembl chr 1:51,188,540...51,606,904

FKBP4

FKBP prolyl isomerase 4

NCBI chr12:2,915,017...2,924,423
Ensembl chr12:2,847,496...2,856,107

FKBP5

FKBP prolyl isomerase 5

NCBI chr 6:35,135,745...35,250,860
Ensembl chr 6:36,337,883...36,452,664

HSP90AA1

heat shock protein 90 alpha family class A member 1

NCBI chr14:82,700,881...82,707,020
Ensembl chr14:102,519,699...102,576,723

HSP90AB1

heat shock protein 90 alpha family class B member 1

NCBI chr 6:43,842,796...43,849,637
Ensembl chr 6:45,125,773...45,133,872

Janus kinase 2

NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626

NCOA1

nuclear receptor coactivator 1

NCBI chr2A:24,485,068...24,764,135
Ensembl chr2A:24,733,117...24,859,488

NCOA2

nuclear receptor coactivator 2

NCBI chr 8:66,632,139...66,929,526
Ensembl chr 8:68,293,018...68,400,479

NCOR1

nuclear receptor corepressor 1

NCBI chr17:34,934,452...35,121,195

NCOR2

nuclear receptor corepressor 2

NCBI chr12:121,913,368...122,155,031
Ensembl chr12:126,201,779...126,372,745

NFYC

nuclear transcription factor Y subunit gamma

NCBI chr 1:39,984,716...40,064,464
Ensembl chr 1:41,304,194...41,383,615

NR3C2

nuclear receptor subfamily 3 group C member 2

NCBI chr 4:140,418,624...140,785,180
Ensembl chr 4:152,108,508...152,430,298

PIAS1

protein inhibitor of activated STAT 1

NCBI chr15:47,006,718...47,141,035
Ensembl chr15:65,276,530...65,410,105

PPARGC1A

PPARG coactivator 1 alpha

NCBI chr 4:18,196,431...18,876,889
Ensembl chr 4:23,483,377...23,581,212

PTGES3

prostaglandin E synthase 3

NCBI chr12:32,221,908...32,247,228
Ensembl chr12:32,476,835...32,503,181

UBE2I

ubiquitin conjugating enzyme E2 I

Ensembl chr16:1,367,288...1,382,575

altered androgen signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

androgen receptor

ISO

RGD

PMID:18008377 PMID:23759327

RGD:2326139 RGD:8693397

NCBI chr X:56,722,828...56,909,004
Ensembl chr X:66,791,081...66,969,357

NCOA2

nuclear receptor coactivator 2

NCBI chr 8:66,632,139...66,929,526
Ensembl chr 8:68,293,018...68,400,479

NCOR2

nuclear receptor corepressor 2

NCBI chr12:121,913,368...122,155,031
Ensembl chr12:126,201,779...126,372,745

altered clathrin-dependent synaptic vesicle endocytosis

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

DNAJC6

DnaJ heat shock protein family (Hsp40) member C6

NCBI chr 1:64,501,805...64,662,999
Ensembl chr 1:66,399,968...66,550,879

synaptojanin 1

NCBI chr21:18,990,526...19,088,839
Ensembl chr21:32,368,949...32,466,994

altered epidermal growth factor/neuregulin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

EGF

epidermal growth factor

NCBI chr 4:102,410,724...102,509,691
Ensembl chr 4:112,977,565...113,076,460

EGFR

epidermal growth factor receptor

ISO

RGD

PMID:19506583 PMID:20519133 PMID:20951313

RGD:5133241 RGD:5133242 RGD:5490965

NCBI chr 7:55,614,042...55,807,285
Ensembl chr 7:56,046,296...56,111,615

ERBB2

erb-b2 receptor tyrosine kinase 2

ISO

RGD

PMID:19078924 PMID:21277552

RGD:4143515 RGD:5133243

NCBI chr17:17,560,337...17,600,808
Ensembl chr17:17,777,434...17,805,862

TGFA

transforming growth factor alpha

NCBI chr2A:70,510,727...70,617,628
Ensembl chr2A:71,625,196...71,731,461

altered Erk5 MAPK signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

MAP2K5

mitogen-activated protein kinase kinase 5

NCBI chr15:46,493,139...46,760,271
Ensembl chr15:64,761,394...65,029,655

MAPK7

mitogen-activated protein kinase 7

NCBI chr17:31,729,429...31,736,216
Ensembl chr17:36,894,146...36,899,969

altered extracellular signal-regulated Raf/Mek/Erk signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BRAF

B-Raf proto-oncogene, serine/threonine kinase

ISO

RGD

PMID:17126425 PMID:18098337 PMID:20951313 PMID:21277552

RGD:2293882 RGD:2298531 RGD:5133242 RGD:5133243

NCBI chr 7:132,651,908...132,855,422
Ensembl chr 7:145,138,510...145,327,115

KRAS

KRAS proto-oncogene, GTPase

ISO

RGD

PMID:16112461 PMID:18772397 PMID:19078924 PMID:19506583 PMID:20951313

RGD:2306732 RGD:4143515 RGD:5133242 RGD:5490965 RGD:5490966

NCBI chr12:61,062,689...61,108,524
Ensembl chr12:63,679,293...63,724,335

MAP2K1

mitogen-activated protein kinase kinase 1

ISO

RGD

PMID:20951313 PMID:21277552

RGD:5133242 RGD:5133243

NCBI chr15:45,337,117...45,438,826
Ensembl chr15:63,613,961...63,714,161

RAF1

Raf-1 proto-oncogene, serine/threonine kinase

NCBI chr 3:12,510,084...12,590,598
Ensembl chr 3:12,853,415...12,932,871

altered Hedgehog signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BOC

BOC cell adhesion associated, oncogene regulated

NCBI chr 3:110,354,576...110,429,954
Ensembl chr 3:117,277,769...117,352,741

DHH

desert hedgehog signaling molecule

NCBI chr12:39,656,046...39,661,439
Ensembl chr12:40,535,740...40,541,123

GLI1

GLI family zinc finger 1

ISO

RGD

PMID:18772397 PMID:21186299

RGD:5490966 RGD:5491005

NCBI chr12:31,453,759...31,466,194
Ensembl chr12:31,710,057...31,722,473

GLI3

GLI family zinc finger 3

NCBI chr 7:42,004,965...42,280,772
Ensembl chr 7:42,056,565...42,322,865

LRP2

LDL receptor related protein 2

NCBI chr2B:56,407,871...56,640,471
Ensembl chr2B:173,873,767...174,103,697

SHH

sonic hedgehog signaling molecule

NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651

SMO

smoothened, frizzled class receptor

NCBI chr 7:121,143,968...121,168,873
Ensembl chr 7:133,668,304...133,693,048

altered hypoxia inducible factor pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

VHL

von Hippel-Lindau tumor suppressor

NCBI chr 3:10,077,630...10,089,499
Ensembl chr 3:10,430,143...10,440,234

altered insulin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

insulin

NCBI chr11:2,200,785...2,202,579
Ensembl chr11:2,218,117...2,231,666

insulin receptor

NCBI chr19:6,393,407...6,578,234
Ensembl chr19:7,260,246...7,414,889

altered insulin-like growth factor signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

IGF1

insulin like growth factor 1

NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177

altered integrin mediated signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ILK

integrin linked kinase

NCBI chr11:6,735,735...6,742,922
Ensembl chr11:6,418,717...6,425,788

ITGA1

integrin subunit alpha 1

NCBI chr 5:61,073,507...61,247,565
Ensembl chr 5:62,692,673...62,865,769

ITGA11

integrin subunit alpha 11

NCBI chr15:47,260,931...47,390,062
Ensembl chr15:66,031,201...66,128,985

ITGA4

integrin subunit alpha 4

ISO

RGD

PMID:11782963 PMID:18772397

RGD:1302879 RGD:5490966

NCBI chr2B:68,719,376...68,802,488
Ensembl chr2B:186,530,187...186,612,203

ITGA8

integrin subunit alpha 8

NCBI chr10:15,838,320...16,045,206
Ensembl chr10:16,114,999...16,321,360

ITGA9

integrin subunit alpha 9

NCBI chr 3:37,349,120...37,722,572
Ensembl chr 3:37,651,395...38,006,363

altered Jak-Stat signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Janus kinase 2

NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626

Janus kinase 3

NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964

altered leptin system pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

INSR

insulin receptor

ISO

increased basal hypothalamic leptin signaling without changes in leptin receptor expression after antisense-mediated hypothalamus-specific Insr knock-down

RGD

PMID:17585961

RGD:2290473

NCBI chr19:6,393,407...6,578,234
Ensembl chr19:7,260,246...7,414,889

LEP

leptin

ISO

RGD

PMID:11102451 PMID:15703762

RGD:1357910 RGD:61790

NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519

LEPR

leptin receptor

ISO

RGD

PMID:11102451 PMID:15703762 PMID:17229951

RGD:1357910 RGD:1600611 RGD:61790

NCBI chr 1:64,772,612...64,881,886
Ensembl chr 1:66,693,926...66,764,768

altered melanocortin system pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AGRP

agouti related neuropeptide

NCBI chr16:47,827,532...47,872,727
Ensembl chr16:67,216,008...67,217,258

MC4R

melanocortin 4 receptor

NCBI chr18:53,744,172...53,747,282
Ensembl chr18:57,069,259...57,070,257

PCSK1

proprotein convertase subtilisin/kexin type 1

ISO

RGD

PMID:11874690 PMID:15189116

RGD:1357925 RGD:1357926

NCBI chr 5:18,917,488...18,960,102
Ensembl chr 5:19,064,004...19,106,486

POMC

proopiomelanocortin

ISO

RGD

PMID:11874690 PMID:15189116

RGD:1357925 RGD:1357926

NCBI chr2A:25,161,668...25,165,600
Ensembl chr2A:25,258,768...25,262,706

syndecan 1

NCBI chr2A:20,187,249...20,211,567
Ensembl chr2A:20,302,589...20,309,848

altered Notch signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

HEY1

hes related family bHLH transcription factor with YRPW motif 1

NCBI chr 8:76,286,433...76,290,507
Ensembl chr 8:77,913,761...77,921,201

NUMB

NUMB endocytic adaptor protein

NCBI chr14:53,854,280...54,046,410
Ensembl chr14:72,714,555...72,798,037

altered Notch signaling pathway involving promoters

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

HEY1

hes related family bHLH transcription factor with YRPW motif 1

NCBI chr 8:76,286,433...76,290,507
Ensembl chr 8:77,913,761...77,921,201

altered Notch signaling pathway involving the macromolecules modifying the main players

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

NUMB

NUMB endocytic adaptor protein

NCBI chr14:53,854,280...54,046,410
Ensembl chr14:72,714,555...72,798,037

PSEN2

presenilin 2

ISO

C. elegans transgenics expressing wild-type and mutant PSEN2

RGD

PMID:16474849

RGD:2302525

NCBI chr 1:202,328,987...202,354,440
Ensembl chr 1:207,320,937...207,346,295

altered Notch signaling pathway involving the main players

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

DLL3

delta like canonical Notch ligand 3

ISO

Mutations in the gene have been associated with Spondylocostal dysostosis

RGD

PMID:12141422

RGD:1304493

NCBI chr19:36,597,420...36,607,021

JAG1

jagged canonical Notch ligand 1

NCBI chr20:10,582,234...10,618,507
Ensembl chr20:10,582,094...10,618,383

NOTCH1

notch receptor 1

ISO

Mutations in the dimerization and/or PEST domain have been associated with human acute T-lymphoblastic leukemias

RGD

PMID:15472075

RGD:1334450

NCBI chr 9:107,568,670...107,621,032
Ensembl chr 9:136,544,639...136,598,740

NOTCH3

notch receptor 3

ISO

Mutations are predominantly found in the EGF repeats and clustered within the first five

RGD

PMID:9388399

RGD:1334441

NCBI chr19:14,692,571...14,733,758
Ensembl chr19:15,678,674...15,715,080

altered p53 signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ETS1

ETS proto-oncogene 1, transcription factor

NCBI chr11:123,272,111...123,400,413
Ensembl chr11:127,174,721...127,288,673

MDM2

MDM2 proto-oncogene

ISO

RGD

PMID:19165225 PMID:23262034

RGD:2316186 RGD:8663434

NCBI chr12:66,322,340...66,357,010
Ensembl chr12:69,102,084...69,133,278

MDM4

MDM4 regulator of p53

NCBI chr 1:180,117,364...180,151,144
Ensembl chr 1:184,406,124...184,439,344

MRE11

MRE11 homolog, double strand break repair nuclease

NCBI chr11:89,418,537...89,500,705
Ensembl chr11:92,918,549...92,985,966

NFYA

nuclear transcription factor Y subunit alpha

ISO

RGD

PMID:22713868 PMID:23263379

RGD:8663430 RGD:8663431

NCBI chr 6:40,661,407...40,688,440
Ensembl chr 6:41,969,561...41,996,963

NFYB

nuclear transcription factor Y subunit beta

ISO

RGD

PMID:22713868 PMID:23263379

RGD:8663430 RGD:8663431

NCBI chr12:101,693,559...101,714,057
Ensembl chr12:105,089,028...105,108,825

NFYC

nuclear transcription factor Y subunit gamma

ISO

RGD

PMID:22713868 PMID:23263379

RGD:8663430 RGD:8663431

NCBI chr 1:39,984,716...40,064,464
Ensembl chr 1:41,304,194...41,383,615

PIN1

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

NCBI chr19:9,389,829...9,404,099
Ensembl chr19:10,053,254...10,066,853

SREBF2

sterol regulatory element binding transcription factor 2

ISO

RGD

PMID:22713868 PMID:23263379

RGD:8663430 RGD:8663431

NCBI chr22:22,725,790...22,799,749
Ensembl chr22:40,811,459...40,884,947

TP53

tumor protein p53

ISO

RGD

PMID:18772397 PMID:19078924 PMID:19165225 PMID:20951313 PMID:22713868 More...

RGD:2316186 RGD:4143515 RGD:5133242 RGD:5490966 RGD:8663430 RGD:8663431 RGD:8693397

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

TP63

tumor protein p63

ISO

RGD

PMID:22713868 PMID:23263379

RGD:8663430 RGD:8663431

NCBI chr 3:186,651,879...186,918,300
Ensembl chr 3:195,199,167...195,474,104

TP73

tumor protein p73

ISO

RGD

PMID:22713868 PMID:23263379

RGD:8663430 RGD:8663431

NCBI chr 1:2,323,399...2,405,295
Ensembl chr 1:3,476,064...3,529,206

vitamin D receptor

NCBI chr12:40,828,413...40,891,700
Ensembl chr12:41,702,742...41,766,192

altered phosphatidylinositol 3-kinase signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

NCBI chr 3:176,182,765...176,272,024
Ensembl chr 3:184,355,785...184,441,977

PTEN

phosphatase and tensin homolog

NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605

altered phosphatidylinositol 3-kinase-Akt signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AKT1

AKT serine/threonine kinase 1

ISO

RGD

PMID:18955974 PMID:21277552

RGD:2313763 RGD:5133243

NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756

AKT2

AKT serine/threonine kinase 2

ISO

RGD

PMID:15166380 PMID:18955974 PMID:19506583

RGD:2313408 RGD:2313763 RGD:5490965

NCBI chr19:37,275,799...37,331,971
Ensembl chr19:45,791,800...45,840,271

AKT3

AKT serine/threonine kinase 3

NCBI chr 1:219,107,482...219,463,140
Ensembl chr 1:224,480,784...224,824,838

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

ISO

RGD

PMID:18955974 PMID:19078924 PMID:20951313 PMID:21277552

RGD:2313763 RGD:4143515 RGD:5133242 RGD:5133243

NCBI chr 3:176,182,765...176,272,024
Ensembl chr 3:184,355,785...184,441,977

PTEN

phosphatase and tensin homolog

ISO

RGD

PMID:18008377 PMID:18955974 PMID:19078924 PMID:19506583 PMID:20951313

RGD:2313763 RGD:2326139 RGD:4143515 RGD:5133242 RGD:5490965

NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605

altered Reelin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

DAB1

DAB adaptor protein 1

ISO

RGD

PMID:12670697 PMID:12764038 PMID:16266828

RGD:1358468 RGD:2324967 RGD:727518

NCBI chr 1:56,279,089...57,529,881
Ensembl chr 1:58,005,136...58,286,708

FYN

FYN proto-oncogene, Src family tyrosine kinase

NCBI chr 6:109,469,750...109,684,086
Ensembl chr 6:113,545,944...113,604,451

ITGA3

integrin subunit alpha 3

NCBI chr17:44,145,974...44,181,343
Ensembl chr17:49,019,892...49,055,245

ITGB1

integrin subunit beta 1

NCBI chr10:33,023,573...33,081,384
Ensembl chr10:33,608,978...33,644,031

LRP8

LDL receptor related protein 8

NCBI chr 1:52,515,534...52,600,390
Ensembl chr 1:54,114,909...54,199,452

PAFAH1B1

platelet activating factor acetylhydrolase 1b regulatory subunit 1

NCBI chr17:2,584,349...2,676,928
Ensembl chr17:2,590,007...2,680,994

PAFAH1B2

platelet activating factor acetylhydrolase 1b catalytic subunit 2

NCBI chr11:111,978,368...112,005,064
Ensembl chr11:115,911,803...115,944,351

PAFAH1B3

platelet activating factor acetylhydrolase 1b catalytic subunit 3

NCBI chr19:39,184,734...39,190,522

RELN

reelin

ISO

RGD

PMID:12670697 PMID:12764038

RGD:1358468 RGD:727518

NCBI chr 7:95,464,285...95,984,813
Ensembl chr 7:108,208,344...108,728,037

SRC

SRC proto-oncogene, non-receptor tyrosine kinase

NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634

VLDLR

very low density lipoprotein receptor

NCBI chr 9:2,428,639...2,463,796
Ensembl chr 9:2,621,199...2,653,980

altered scatter factor/hepatocyte growth factor signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

MET

MET proto-oncogene, receptor tyrosine kinase

ISO

RGD

PMID:19506583 PMID:20519133 PMID:20951313 PMID:21277552

RGD:5133241 RGD:5133242 RGD:5133243 RGD:5490965

NCBI chr 7:108,646,278...108,772,238
Ensembl chr 7:121,365,438...121,468,159

altered transforming growth factor-beta Smad dependent signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

SMAD2

SMAD family member 2

ISO

RGD

PMID:17613544 PMID:18662538

RGD:2306282 RGD:2308865

NCBI chr18:41,213,001...41,309,902
Ensembl chr18:44,580,905...44,668,530

SMAD3

SMAD family member 3

ISO

RGD

PMID:17613544 PMID:18772397

RGD:2306282 RGD:5490966

NCBI chr15:46,013,764...46,143,126
Ensembl chr15:64,284,949...64,414,185

SMAD4

SMAD family member 4

ISO

RGD

PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583

RGD:2306282 RGD:2308865 RGD:5490965 RGD:5490966

NCBI chr18:44,402,112...44,456,779
Ensembl chr18:47,764,568...47,797,359

SMAD family member 7

NCBI chr18:42,306,324...42,337,214

TGFB1

transforming growth factor beta 1

ISO

RGD

PMID:17613544 PMID:18313409

RGD:2299005 RGD:2306282

NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973

TGFBR1

transforming growth factor beta receptor 1

ISO

RGD

PMID:17613544 PMID:18313409

RGD:2299005 RGD:2306282

NCBI chr 9:70,195,007...70,243,514
Ensembl chr 9:98,332,739...98,362,748

TGFBR2

transforming growth factor beta receptor 2

ISO

RGD

PMID:17613544 PMID:18313409 PMID:18662538 PMID:18772397 PMID:19506583

RGD:2299005 RGD:2306282 RGD:2308865 RGD:5490965 RGD:5490966

NCBI chr 3:30,536,187...30,623,653
Ensembl chr 3:30,854,460...30,938,856

altered vascular endothelial growth factor signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

FLT4

fms related receptor tyrosine kinase 4

NCBI chr 5:175,804,728...175,852,703
Ensembl chr 5:183,115,856...183,149,006

altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

KDR

kinase insert domain receptor

NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109

VEGFA

vascular endothelial growth factor A

NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353

altered vascular endothelial growth factor signaling pathway involving the main players

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

FLT4

fms related receptor tyrosine kinase 4

NCBI chr 5:175,804,728...175,852,703
Ensembl chr 5:183,115,856...183,149,006

KDR

kinase insert domain receptor

NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109

VEGFA

vascular endothelial growth factor A

NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353

altered visual phototransduction pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CNGA1

cyclic nucleotide gated channel subunit alpha 1

NCBI chr 4:74,196,877...74,213,563
Ensembl chr 4:84,910,653...84,945,248

CNGB1

cyclic nucleotide gated channel subunit beta 1

NCBI chr16:38,160,056...38,249,474
Ensembl chr16:57,292,093...57,375,460

GUCA1B

guanylate cyclase activator 1B

NCBI chr 6:41,771,537...41,783,364
Ensembl chr 6:43,072,469...43,083,838

phosphodiesterase 6A

NCBI chr 5:145,283,505...145,369,596
Ensembl chr 5:151,294,041...151,375,832

phosphodiesterase 6B

Ensembl chr 4:646,516...701,680

phosphodiesterase 6G

NCBI chr17:76,105,827...76,122,750

rhodopsin

NCBI chr 3:126,586,510...126,593,028
Ensembl chr 3:133,938,419...133,944,928

SAG

S-antigen visual arrestin

NCBI chr2B:120,532,049...120,574,914
Ensembl chr2B:239,449,910...239,487,537

altered Wnt signaling, canonical pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

APC

APC regulator of WNT signaling pathway

NCBI chr 5:108,070,697...108,208,273
Ensembl chr 5:113,904,352...114,009,709

axin 1

Ensembl chr16:278,239...337,891

axin 2

NCBI chr17:59,476,336...59,509,358
Ensembl chr17:64,688,416...64,720,086

CTNNB1

catenin beta 1

ISO

RGD

PMID:18432252 PMID:19078924

RGD:2293188 RGD:4143515

NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030

LRP5

LDL receptor related protein 5

NCBI chr11:63,396,511...63,534,471
Ensembl chr11:66,735,246...66,839,817

MAP3K1

mitogen-activated protein kinase kinase kinase 1

NCBI chr 5:57,116,405...57,197,017
Ensembl chr 5:58,745,579...58,826,959

TCF7L2

transcription factor 7 like 2

NCBI chr10:109,541,524...109,759,499
Ensembl chr10:112,978,167...113,192,281

Wnt family member 9A

NCBI chr 1:203,320,990...203,350,599
Ensembl chr 1:208,300,609...208,327,191

androgen signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

androgen receptor

NCBI chr X:56,722,828...56,909,004
Ensembl chr X:66,791,081...66,969,357

CARM1

coactivator associated arginine methyltransferase 1

NCBI chr19:10,424,993...10,476,702
Ensembl chr19:11,144,733...11,195,948

CREB binding protein

NCBI chr16:2,645,445...2,800,975
Ensembl chr16:3,820,519...3,974,206

DNAJA2

DnaJ heat shock protein family (Hsp40) member A2

NCBI chr16:27,223,414...27,240,726
Ensembl chr16:46,113,088...46,130,028

EP300

E1A binding protein p300

NCBI chr22:21,986,467...22,076,921
Ensembl chr22:40,079,503...40,168,604

HSP90AA1

heat shock protein 90 alpha family class A member 1

NCBI chr14:82,700,881...82,707,020
Ensembl chr14:102,519,699...102,576,723

HSP90AB1

heat shock protein 90 alpha family class B member 1

NCBI chr 6:43,842,796...43,849,637
Ensembl chr 6:45,125,773...45,133,872

HSPA8

heat shock protein family A (Hsp70) member 8

NCBI chr11:117,890,545...117,895,262
Ensembl chr11:121,809,800...121,815,773

NCOA1

nuclear receptor coactivator 1

NCBI chr2A:24,485,068...24,764,135
Ensembl chr2A:24,733,117...24,859,488

NCOA2

nuclear receptor coactivator 2

NCBI chr 8:66,632,139...66,929,526
Ensembl chr 8:68,293,018...68,400,479

NCOA3

nuclear receptor coactivator 3

NCBI chr20:43,838,227...43,992,407
Ensembl chr20:45,000,422...45,073,549

NCOR1

nuclear receptor corepressor 1

NCBI chr17:34,934,452...35,121,195

NCOR2

nuclear receptor corepressor 2

NCBI chr12:121,913,368...122,155,031
Ensembl chr12:126,201,779...126,372,745

PIAS2

protein inhibitor of activated STAT 2

NCBI chr18:40,067,901...40,196,078
Ensembl chr18:43,622,455...43,728,675

PRMT1

protein arginine methyltransferase 1

NCBI chr19:46,691,795...46,705,179
Ensembl chr19:55,610,938...55,623,135

ST13

ST13 Hsp70 interacting protein

NCBI chr22:21,719,713...21,751,912
Ensembl chr22:39,815,337...39,848,049

STIP1

stress induced phosphoprotein 1

NCBI chr11:59,542,760...59,560,758
Ensembl chr11:62,889,052...62,906,902

angiopoietin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

angiopoietin 1

NCBI chr 8:103,893,234...104,137,661
Ensembl chr 8:106,042,041...106,286,783

TEK

TEK receptor tyrosine kinase

NCBI chr 9:26,955,339...27,077,809
Ensembl chr 9:27,561,421...27,683,572

angiotensin (1-7) signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACE

angiotensin I converting enzyme

ISO

RGD

PMID:10642323 PMID:15283675

RGD:1581953 RGD:1598433

NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853

ACE2

angiotensin converting enzyme 2

NCBI chr X:8,189,267...8,229,415
Ensembl chr X:15,470,896...15,510,891

angiotensinogen

NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044

MAS1

MAS1 proto-oncogene, G protein-coupled receptor

ISO

RGD

PMID:15951342 PMID:16520407

RGD:1581931 RGD:1581938

NCBI chr 6:157,774,098...157,799,983
Ensembl chr 6:162,801,416...162,802,393

MME

membrane metalloendopeptidase

NCBI chr 3:152,085,694...152,240,148
Ensembl chr 3:160,197,566...160,292,119

angiotensin II signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACE

angiotensin I converting enzyme

NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853

angiotensinogen

NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044

AGTR1

angiotensin II receptor type 1

NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380

AGTR2

angiotensin II receptor type 2

NCBI chr X:105,252,903...105,257,171
Ensembl chr X:115,671,594...115,672,685

CCL2

C-C motif chemokine ligand 2

NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384

CMA1

chymase 1

ISO

RGD

PMID:15638741 PMID:15869764

RGD:1581742 RGD:1581745

NCBI chr14:5,277,269...5,280,335
Ensembl chr14:23,400,345...23,403,548

Janus kinase 2

NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626

OLR1

oxidized low density lipoprotein receptor 1

NCBI chr12:10,196,712...10,210,432
Ensembl chr12:10,445,202...10,461,071

PDPK1

3-phosphoinositide dependent protein kinase 1

NCBI chr16:1,394,447...1,463,735

PLA2G6

phospholipase A2 group VI

NCBI chr22:18,998,060...19,094,507
Ensembl chr22:36,849,794...36,919,509
Ensembl chr22:36,849,794...36,919,509

PRKCZ

protein kinase C zeta

NCBI chr 1:763,942...901,531
Ensembl chr 1:1,920,219...2,045,855

angiotensin II signaling pathway via AT1 receptor

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

angiotensinogen

NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044

AGTR1

angiotensin II receptor type 1

ISO

RGD

PMID:9287353 PMID:10977869 PMID:12446719 PMID:14559250

RGD:1581825 RGD:2316188 RGD:5133683 RGD:629553

NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380

AGTRAP

angiotensin II receptor associated protein

NCBI chr 1:10,498,245...10,512,906
Ensembl chr 1:11,715,672...11,730,326

ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

NCBI chr11:67,763,944...67,831,728
Ensembl chr11:70,985,926...71,028,342

arrestin beta 1

NCBI chr11:70,319,935...70,411,276
Ensembl chr11:73,630,276...73,654,155

arrestin beta 2

NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517

GNA11

G protein subunit alpha 11

NCBI chr19:2,120,398...2,149,161
Ensembl chr19:3,074,483...3,102,124

GRK2

G protein-coupled receptor kinase 2

NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066

GRK3

G protein-coupled receptor kinase 3

NCBI chr22:6,579,664...6,789,846
Ensembl chr22:24,353,533...24,509,560

GRK5

G protein-coupled receptor kinase 5

NCBI chr10:115,776,236...116,026,221
Ensembl chr10:119,200,688...119,450,809

GRK6

G protein-coupled receptor kinase 6

NCBI chr 5:172,704,978...172,744,907
Ensembl chr 5:179,790,662...179,807,410

JAK2

Janus kinase 2

ISO

RGD

PMID:9287353 PMID:9314843

RGD:5133683 RGD:6478796

NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626

LOC100986730

guanine nucleotide-binding protein G(q) subunit alpha

NCBI chr 9:46,816,409...47,129,116
Ensembl chr 9:76,575,815...76,773,849

RGS2

regulator of G protein signaling 2

NCBI chr 1:168,273,112...168,276,348
Ensembl chr 1:172,566,701...172,569,955

tyrosine kinase 2

NCBI chr19:9,901,612...9,932,623
Ensembl chr19:10,565,490...10,594,541

angiotensin II signaling pathway via AT2 receptor

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AGT

angiotensinogen

ISO

RGD

PMID:16286564 PMID:16286568 PMID:22949090

RGD:1582434 RGD:1582435 RGD:7401256

NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044

AGTR2

angiotensin II receptor type 2

ISO

RGD

PMID:10977869 PMID:22949090

RGD:1581825 RGD:7401256

NCBI chr X:105,252,903...105,257,171
Ensembl chr X:115,671,594...115,672,685

CNKSR1

connector enhancer of kinase suppressor of Ras 1

NCBI chr 1:25,438,092...25,450,953
Ensembl chr 1:26,505,513...26,517,225

DUSP1

dual specificity phosphatase 1

NCBI chr 5:168,121,536...168,124,671
Ensembl chr 5:175,032,803...175,035,960

ERBB3

erb-b2 receptor tyrosine kinase 3

NCBI chr12:32,811,533...32,834,958
Ensembl chr12:33,063,434...33,084,994

GNAI2

G protein subunit alpha i2

NCBI chr 3:50,154,731...50,187,948
Ensembl chr 3:51,398,981...51,421,988

GNAI3

G protein subunit alpha i3

NCBI chr 1:111,925,668...111,971,941
Ensembl chr 1:111,154,060...111,198,768

MTUS1

microtubule associated scaffold protein 1

NCBI chr 8:16,863,307...17,020,684

PTPN6

protein tyrosine phosphatase non-receptor type 6

NCBI chr12:7,075,879...7,093,041
Ensembl chr12:6,991,099...7,008,830

SLC9A6

solute carrier family 9 member A6

NCBI chr X:125,099,378...125,171,161
Ensembl chr X:135,378,094...135,439,781

TIMP3

TIMP metallopeptidase inhibitor 3

NCBI chr22:13,811,297...13,872,799
Ensembl chr22:31,662,562...31,723,964

ZBTB16

zinc finger and BTB domain containing 16

NCBI chr11:108,938,414...109,133,819
Ensembl chr11:112,780,380...112,977,164

angiotensin III signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

angiotensinogen

NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044

AGTR1

angiotensin II receptor type 1

NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380

AGTR2

angiotensin II receptor type 2

NCBI chr X:105,252,903...105,257,171
Ensembl chr X:115,671,594...115,672,685

ENPEP

glutamyl aminopeptidase

ISO

RGD

PMID:15638741 PMID:16537183

RGD:1581649 RGD:1581742

NCBI chr 4:102,969,397...103,056,978
Ensembl chr 4:113,532,126...113,620,654

angiotensin III signaling pathway via AT1 receptor

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

angiotensinogen

NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044

AGTR1

angiotensin II receptor type 1

NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380

angiotensin III signaling pathway via AT2 receptor

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

angiotensinogen

NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044

AGTR2

angiotensin II receptor type 2

NCBI chr X:105,252,903...105,257,171
Ensembl chr X:115,671,594...115,672,685

angiotensin IV signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

angiotensinogen

NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044

ANPEP

alanyl aminopeptidase, membrane

ISO

RGD

PMID:15638741 PMID:16537183

RGD:1581649 RGD:1581742

NCBI chr15:68,479,349...68,509,238
Ensembl chr15:87,681,826...87,703,713

LNPEP

leucyl and cystinyl aminopeptidase

ISO

RGD

PMID:11282364 PMID:12591177

RGD:1581864 RGD:1582105

NCBI chr 5:92,247,060...92,348,900
Ensembl chr 5:97,842,110...97,893,876

RNPEP

arginyl aminopeptidase

NCBI chr 1:177,579,349...177,602,865
Ensembl chr 1:181,880,404...181,903,906

angiotensin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

angiotensinogen

NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044

apelin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

apelin

NCBI chr X:118,775,509...118,785,224

apelin receptor

NCBI chr11:52,475,088...52,479,102
Ensembl chr 3:159,967,360...159,968,502

Arf family mediated signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AP2A1

adaptor related protein complex 2 subunit alpha 1

ISO

PID

PID:200195

NCBI chr19:46,779,196...46,820,055
Ensembl chr19:55,694,070...55,736,570

AP2M1

adaptor related protein complex 2 subunit mu 1

ISO

PID

PID:200195

NCBI chr 3:181,210,045...181,219,327
Ensembl chr 3:189,692,898...189,702,261

ARF1

ADP ribosylation factor 1

ISO

PID

PID:200195

NCBI chr 1:203,484,803...203,501,395
Ensembl chr 1:208,695,615...208,712,105

ARFGAP1

ADP ribosylation factor GTPase activating protein 1

ISO

PID

PID:200195

NCBI chr20:59,656,731...59,674,802
Ensembl chr20:61,197,583...61,214,635

ARFIP2

ADP ribosylation factor interacting protein 2

ISO

PID

PID:200195

NCBI chr11:6,608,393...6,613,245
Ensembl chr11:6,290,034...6,296,817

ARL6

ADP ribosylation factor like GTPase 6

NCBI chr 3:94,832,577...94,870,531
Ensembl chr 3:101,519,718...101,556,419

ASAP1

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

ISO

PID

PID:200195

NCBI chr 8:126,688,608...127,080,662
Ensembl chr 8:129,418,796...130,021,261

CD4

CD4 molecule

ISO

PID

PID:200195

NCBI chr12:6,920,587...6,951,814
Ensembl chr12:6,834,011...6,864,204

CLTA

clathrin light chain A

ISO

PID

PID:200195

NCBI chr 9:36,040,566...36,061,744
Ensembl chr 9:36,840,868...36,862,528

CLTB

clathrin light chain B

ISO

PID

PID:200195

NCBI chr 5:171,689,273...171,713,198

COPA

COPI coat complex subunit alpha

ISO

PID

PID:200195

NCBI chr 1:135,643,677...135,697,584
Ensembl chr 1:139,564,084...139,618,520

CYTH2

cytohesin 2

ISO

PID

PID:200195

NCBI chr19:45,471,277...45,481,350
Ensembl chr19:54,063,560...54,073,017

GBF1

golgi brefeldin A resistant guanine nucleotide exchange factor 1

ISO

PID

PID:200195

NCBI chr10:98,849,000...98,986,443
Ensembl chr10:102,316,329...102,452,439

GGA3

golgi associated, gamma adaptin ear containing, ARF binding protein 3

ISO

PID

PID:200195

NCBI chr17:69,185,045...69,208,766
Ensembl chr17:74,737,164...74,762,039

GIT ArfGAP 1

NCBI chr17:27,185,025...27,201,146
Ensembl chr17:27,706,776...27,717,857

GOSR2

golgi SNAP receptor complex member 2

ISO

PID

PID:200195

NCBI chr17:10,561,574...10,580,489
Ensembl chr17:10,715,452...10,759,004

KDELR1

KDEL endoplasmic reticulum protein retention receptor 1

ISO

PID

PID:200195

NCBI chr19:45,382,456...45,391,338
Ensembl chr19:53,975,895...53,984,914

PIP5K1A

phosphatidylinositol-4-phosphate 5-kinase type 1 alpha

ISO

PID

PID:200195

NCBI chr 1:126,547,793...126,598,618
Ensembl chr 1:130,195,974...130,246,198

PLD2

phospholipase D2

ISO

PID

PID:200195

NCBI chr17:4,853,919...4,870,254
Ensembl chr17:4,843,217...4,858,425

RAC1

Rac family small GTPase 1

ISO

PID

PID:200195

NCBI chr 7:7,039,379...7,068,866

USO1

USO1 vesicle transport factor

ISO

PID

PID:200195

NCBI chr 4:48,391,293...48,480,909
Ensembl chr 4:54,229,601...54,317,158

aryl hydrocarbon receptor signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AHR

aryl hydrocarbon receptor

NCBI chr 7:17,949,254...17,998,737
Ensembl chr 7:17,278,637...17,326,171

ARNT

aryl hydrocarbon receptor nuclear translocator

NCBI chr 1:126,160,017...126,226,222
Ensembl chr 1:129,809,431...129,875,629

ARNT2

aryl hydrocarbon receptor nuclear translocator 2

NCBI chr15:59,376,993...59,573,925

ataxia telangiectasia-mutated (ATM) signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ATM

ATM serine/threonine kinase

ISO

RGD

PMID:21533982 PMID:23532176

RGD:8661225 RGD:8661232

NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041

BAZ1B

bromodomain adjacent to zinc finger domain 1B

Ensembl chr 7:80,594,626...80,675,709

BRCA1

BRCA1 DNA repair associated

NCBI chr17:14,197,946...14,279,064
Ensembl chr17:14,428,526...14,506,815

BRCC3

BRCA1/BRCA2-containing complex subunit 3

NCBI chr X:144,550,320...144,592,795
Ensembl chr X:154,389,283...154,428,669

EYA1

EYA transcriptional coactivator and phosphatase 1

NCBI chr 8:67,728,057...68,060,069
Ensembl chr 8:69,387,769...69,551,829

EYA3

EYA transcriptional coactivator and phosphatase 3

NCBI chr 1:27,230,623...27,349,355
Ensembl chr 1:28,270,116...28,386,878

KAT5

lysine acetyltransferase 5

ISO

RGD

PMID:21533982 PMID:23532176

RGD:8661225 RGD:8661232

NCBI chr11:61,071,118...61,078,667
Ensembl chr11:64,404,572...64,412,667

KDM4A

lysine demethylase 4A

ISO

RGD

PMID:24002223 PMID:24326623

RGD:8661237 RGD:8661242

NCBI chr 1:42,949,977...43,005,684
Ensembl chr 1:44,325,624...44,380,163

L3MBTL1

L3MBTL histone methyl-lysine binding protein 1

ISO

RGD

PMID:24002223 PMID:24326623

RGD:8661237 RGD:8661242

NCBI chr20:39,846,011...39,889,267
Ensembl chr20:40,946,487...40,974,309

LOC100994157

histone H2AX

ISO

RGD

PMID:21533982 PMID:24002223

RGD:8661232 RGD:8661242

NCBI chr11:113,932,078...113,933,679

MDC1

mediator of DNA damage checkpoint 1

ISO

RGD

PMID:21533982 PMID:24002223

RGD:8661232 RGD:8661242

NCBI chr 6:30,444,570...30,462,432
Ensembl chr 6:31,314,560...31,329,243

MRE11

MRE11 homolog, double strand break repair nuclease

NCBI chr11:89,418,537...89,500,705
Ensembl chr11:92,918,549...92,985,966

nibrin

NCBI chr 8:86,622,797...86,674,202
Ensembl chr 8:88,575,198...88,626,307

OTUB1

OTU deubiquitinase, ubiquitin aldehyde binding 1

NCBI chr11:59,342,820...59,355,386
Ensembl chr11:62,690,542...62,706,542

PIAS1

protein inhibitor of activated STAT 1

NCBI chr15:47,006,718...47,141,035
Ensembl chr15:65,276,530...65,410,105

PIAS4

protein inhibitor of activated STAT 4

NCBI chr19:3,030,885...3,062,642
Ensembl chr19:3,982,555...4,015,167

PPM1D

protein phosphatase, Mg2+/Mn2+ dependent 1D

ISO

RGD

PMID:21533982 PMID:24002223

RGD:8661232 RGD:8661242

NCBI chr17:54,698,338...54,761,889
Ensembl chr17:59,824,566...59,887,015

PPP2CA

protein phosphatase 2 catalytic subunit alpha

ISO

RGD

PMID:21533982 PMID:24002223

RGD:8661232 RGD:8661242

NCBI chr 5:129,599,606...129,629,312
Ensembl chr 5:135,751,958...135,765,786

PPP4C

protein phosphatase 4 catalytic subunit

Ensembl chr16:30,450,467...30,464,446

PPP5C

protein phosphatase 5 catalytic subunit

NCBI chr19:43,329,680...43,373,282
Ensembl chr19:51,865,317...51,909,027

PPP6C

protein phosphatase 6 catalytic subunit

NCBI chr 9:96,267,918...96,311,159
Ensembl chr 9:124,783,173...124,825,877

PSMD14

proteasome 26S subunit, non-ATPase 14

NCBI chr2B:48,602,395...48,705,229
Ensembl chr2B:165,972,229...166,074,879

PWWP3A

PWWP domain containing 3A, DNA repair factor

Ensembl chr19:1,331,312...1,352,260

RAD50

RAD50 double strand break repair protein

NCBI chr 5:127,972,630...128,059,911
Ensembl chr 5:134,134,495...134,222,261

RBBP8

RB binding protein 8, endonuclease

NCBI chr18:16,181,652...16,274,597
Ensembl chr18:19,811,989...19,903,522

RIF1

replication timing regulatory factor 1

NCBI chr2B:38,721,658...38,818,488
Ensembl chr2B:155,985,960...156,052,926

RNF168

ring finger protein 168

ISO

RGD

PMID:21533982 PMID:24326623

RGD:8661232 RGD:8661237

NCBI chr 3:193,814,785...193,848,620
Ensembl chr 3:203,756,589...203,790,687

RNF20

ring finger protein 20

NCBI chr 9:72,738,132...72,767,868
Ensembl chr 9:100,732,342...100,761,258

RNF4

ring finger protein 4

NCBI chr 4:2,614,918...2,661,785
Ensembl chr 4:2,540,612...2,563,937

RNF40

ring finger protein 40

NCBI chr16:24,194,293...24,207,460
Ensembl chr16:31,129,352...31,142,280

RNF8

ring finger protein 8

ISO

RGD

PMID:21533982 PMID:24326623

RGD:8661232 RGD:8661237

NCBI chr 6:36,918,705...36,955,380
Ensembl chr 6:38,108,414...38,145,949

TP53BP1

tumor protein p53 binding protein 1

NCBI chr15:22,364,696...22,472,499
Ensembl chr15:40,519,012...40,626,741

TRIP12

thyroid hormone receptor interactor 12

NCBI chr2B:117,013,343...117,175,296
Ensembl chr2B:235,820,182...235,979,780

UBE2N

ubiquitin conjugating enzyme E2 N

ISO

RGD

PMID:21533982 PMID:24326623

RGD:8661232 RGD:8661237

NCBI chr12:90,951,446...90,984,075

UBR5

ubiquitin protein ligase E3 component n-recognin 5

NCBI chr 8:98,904,557...99,064,121
Ensembl chr 8:101,067,435...101,224,913

USP16

ubiquitin specific peptidase 16

NCBI chr21:15,455,805...15,487,853
Ensembl chr21:28,843,749...28,876,267

USP3

ubiquitin specific peptidase 3

NCBI chr15:42,450,782...42,541,162
Ensembl chr15:60,746,406...60,830,535

USP44

ubiquitin specific peptidase 44

NCBI chr12:93,111,293...93,146,889
Ensembl chr12:96,503,794...96,536,094

VCP

valosin containing protein

ISO

RGD

PMID:24002223 PMID:24326623

RGD:8661237 RGD:8661242

NCBI chr 9:34,907,147...34,923,227
Ensembl chr 9:35,712,937...35,729,588

atrial natriuretic peptide signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CORIN

corin, serine peptidase

NCBI chr 4:74,311,036...74,555,742
Ensembl chr 4:85,043,182...85,286,573

NPPA

natriuretic peptide A

ISO

RGD

PMID:12608696 PMID:15758553 PMID:16010968

RGD:1578335 RGD:1580001 RGD:1626242

NCBI chr 1:10,608,025...10,610,287
Ensembl chr 1:11,825,072...11,827,373

NPR1

natriuretic peptide receptor 1

NCBI chr 1:129,034,972...129,050,439
Ensembl chr 1:132,664,948...132,679,327

auditory mechanotransduction pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

actin beta

actin gamma 1

NCBI chr17:75,965,911...75,968,822
Ensembl chr17:81,668,221...81,671,087

ADGRV1

adhesion G protein-coupled receptor V1

NCBI chr 5:24,208,844...24,811,284
Ensembl chr 5:24,341,808...24,945,477

ESPN

espin

ISO

RGD

PMID:19804752 PMID:20624897

RGD:8547667 RGD:8547669

NCBI chr 1:5,184,666...5,222,473

LOC100983880

cadherin-23

ISO

RGD

PMID:19804752 PMID:22177415

RGD:8547667 RGD:8547671

NCBI chr10:67,866,979...68,286,008
Ensembl chr10:70,434,801...70,810,240

myosin XVA

NCBI chr17:32,661,499...32,723,320

myosin IC

NCBI chr17:1,446,506...1,475,634
Ensembl chr17:1,345,143...1,375,540

myosin IIIA

NCBI chr10:26,104,588...26,389,942
Ensembl chr10:26,469,742...26,754,989

MYO6

myosin VI

ISO

RGD

PMID:20624897 PMID:22715884

RGD:8547669 RGD:8547672

NCBI chr 6:73,593,794...73,764,352
Ensembl chr 6:76,951,634...77,048,796

MYO7A

myosin VIIA

ISO

RGD

PMID:19804752 PMID:22177415

RGD:8547667 RGD:8547671

NCBI chr11:72,187,024...72,265,931
Ensembl chr11:75,834,185...75,907,752

otoferlin

NCBI chr2A:26,454,010...26,555,642
Ensembl chr2A:26,546,959...26,647,278

PCDH15

protocadherin related 15

ISO

RGD

PMID:19804752 PMID:22177415

RGD:8547667 RGD:8547671

NCBI chr10:50,452,290...52,236,538
Ensembl chr10:52,666,969...53,536,611

plastin 1

NCBI chr 3:139,629,825...139,747,080
Ensembl chr 3:147,289,205...147,338,600

plastin 3

NCBI chr X:104,656,110...104,745,702
Ensembl chr X:115,160,032...115,250,144

PTPRQ

protein tyrosine phosphatase receptor type Q

NCBI chr12:77,957,758...78,200,206
Ensembl chr12:81,068,545...81,310,857

SLC17A8

solute carrier family 17 member 8

NCBI chr12:97,935,177...98,001,240
Ensembl chr12:101,342,113...101,405,844

USH1C

USH1 protein network component harmonin

ISO

RGD

PMID:19804752 PMID:22177415

RGD:8547667 RGD:8547671

NCBI chr11:17,548,501...17,598,923
Ensembl chr11:17,233,854...17,284,256

USH1G

USH1 protein network component sans

NCBI chr17:68,861,622...68,868,822
Ensembl chr17:74,419,769...74,424,794

usherin

NCBI chr 1:191,193,130...191,994,664
Ensembl chr 1:196,048,086...196,850,216

whirlin

NCBI chr 9:85,500,222...85,604,417
Ensembl chr 9:113,863,872...113,966,758

bile acid signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ABCB11

ATP binding cassette subfamily B member 11

NCBI chr2B:56,199,434...56,311,773
Ensembl chr2B:173,664,518...173,776,379

ABCC2

ATP binding cassette subfamily C member 2

NCBI chr10:96,385,534...96,458,571
Ensembl chr10:99,889,160...99,947,270

ABCC4

ATP binding cassette subfamily C member 4

NCBI chr13:76,193,929...76,476,119
Ensembl chr13:95,349,915...95,582,058

ABCG5

ATP binding cassette subfamily G member 5

NCBI chr2A:43,896,188...43,922,756
Ensembl chr2A:44,745,183...44,771,012

ABCG8

ATP binding cassette subfamily G member 8

NCBI chr2A:43,922,787...43,966,678
Ensembl chr2A:44,771,247...44,904,830

ACAT2

acetyl-CoA acetyltransferase 2

NCBI chr 6:157,644,894...157,661,965
Ensembl chr 6:162,656,497...162,673,606

ALDH1L1

aldehyde dehydrogenase 1 family member L1

NCBI chr 3:123,166,630...123,244,257
Ensembl chr 3:130,484,862...130,562,934

CYP27A1

cytochrome P450 family 27 subfamily A member 1

NCBI chr2B:106,042,235...106,076,840
Ensembl chr2B:224,637,238...224,671,474

CYP7A1

cytochrome P450 family 7 subfamily A member 1

ISO

RGD

PMID:28774887 PMID:30223280

RGD:15045601 RGD:15045612

NCBI chr 8:54,942,509...54,952,500
Ensembl chr 8:56,593,799...56,604,037

CYP8B1

cytochrome P450 family 8 subfamily B member 1

NCBI chr 3:42,775,679...42,779,440
Ensembl chr 3:43,824,423...43,842,716

DGAT2

diacylglycerol O-acyltransferase 2

NCBI chr11:70,824,791...70,857,530
Ensembl chr11:74,126,169...74,158,854

HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785

NR1H3

nuclear receptor subfamily 1 group H member 3

NCBI chr11:47,195,122...47,215,277
Ensembl chr11:47,748,353...47,768,672

NR1H4

nuclear receptor subfamily 1 group H member 4

ISO

RGD

PMID:25263431 PMID:27090119 PMID:28774887 PMID:29235094 PMID:30061734 More...

RGD:15042870 RGD:15042872 RGD:15045601 RGD:15045610 RGD:15045612 RGD:15090804 RGD:15092071

NCBI chr12:98,052,778...98,144,085
Ensembl chr12:101,457,885...101,548,058

PRKAA1

protein kinase AMP-activated catalytic subunit alpha 1

NCBI chr 5:69,581,748...69,620,721
Ensembl chr 5:74,627,830...74,666,505

SLC10A1

solute carrier family 10 member 1

NCBI chr14:50,369,663...50,390,984
Ensembl chr14:69,240,602...69,261,904

SLCO1A2

solute carrier organic anion transporter family member 1A2

NCBI chr12:64,963,090...65,029,673
Ensembl chr12:67,566,066...67,632,608

Bone morphogenetic proteins signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AHSG

alpha 2-HS glycoprotein

ISO

PID

PID:200144

NCBI chr 3:183,644,223...183,652,620
Ensembl chr 3:192,110,770...192,119,915

BAMBI

BMP and activin membrane bound inhibitor

ISO

PID

PID:200144

NCBI chr10:28,833,690...28,839,164
Ensembl chr10:29,187,857...29,193,324

BMP2

bone morphogenetic protein 2

ISO

PID
RGD

PMID:16361357

PID:200144 RGD:1580077

NCBI chr20:6,765,161...6,777,728
Ensembl chr20:6,546,173...6,558,610

BMP4

bone morphogenetic protein 4

ISO

RGD
PID

PMID:18985159

PID:200144 RGD:11553861

NCBI chr14:34,542,132...34,549,286
Ensembl chr14:52,821,872...52,828,752

BMP6

bone morphogenetic protein 6

ISO

PID

PID:200144

NCBI chr 6:7,564,164...7,720,341
Ensembl chr 6:7,848,249...8,000,649

BMP7

bone morphogenetic protein 7

ISO

PID

PID:200144

NCBI chr20:53,509,484...53,606,889
Ensembl chr20:54,788,974...54,885,021

BMPR1A

bone morphogenetic protein receptor type 1A

ISO

PID

PID:200144

NCBI chr10:83,185,040...83,353,239
Ensembl chr10:86,837,469...86,912,912

BMPR1B

bone morphogenetic protein receptor type 1B

ISO

PID

PID:200144

NCBI chr 4:87,125,911...87,523,084
Ensembl chr 4:98,088,072...98,195,848

BMPR2

bone morphogenetic protein receptor type 2

ISO

PID
RGD

PMID:16361357

PID:200144 RGD:1580077

NCBI chr2B:89,631,622...89,823,438
Ensembl chr2B:207,780,741...207,961,072

CER1

cerberus 1, DAN family BMP antagonist

ISO

PID

PID:200144

NCBI chr 9:14,552,062...14,559,632
Ensembl chr 9:15,063,766...15,066,776

CHRD

chordin

ISO

PID

PID:200144

NCBI chr 3:181,417,140...181,460,236
Ensembl chr 3:189,898,856...189,908,573

CHRDL1

chordin like 1

ISO

PID

PID:200144

NCBI chr X:99,781,730...99,915,778
Ensembl chr X:110,251,525...110,375,289

CTDSP1

CTD small phosphatase 1

ISO

PID

PID:200144

NCBI chr2B:105,658,394...105,664,571
Ensembl chr2B:224,254,460...224,262,000

CTDSP2

CTD small phosphatase 2

ISO

PID

PID:200144

NCBI chr12:31,079,686...31,106,789
Ensembl chr12:31,340,313...31,367,164

CTDSPL

CTD small phosphatase like

ISO

PID

PID:200144

NCBI chr 3:37,761,101...37,883,330
Ensembl chr 3:38,127,971...38,166,485

FST

follistatin

ISO

PID

PID:200144

NCBI chr 5:60,544,495...60,550,516

GREM1

gremlin 1, DAN family BMP antagonist

ISO

PID

PID:200144

NCBI chr15:11,213,870...11,230,619

GSK3B

glycogen synthase kinase 3 beta

ISO

PID

PID:200144

NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771

HJV

hemojuvelin BMP co-receptor

ISO

PID

PID:200144

NCBI chr 1:121,738,465...121,742,743
Ensembl chr 1:113,926,383...113,930,761

MAP3K7

mitogen-activated protein kinase kinase kinase 7

ISO

PID

PID:200144

NCBI chr 6:88,398,329...88,470,926
Ensembl chr 6:91,664,263...91,737,468

MAPK1

mitogen-activated protein kinase 1

ISO

PID

PID:200144

NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335

NOG

noggin

ISO

PID

PID:200144

NCBI chr17:50,669,186...50,671,081
Ensembl chr17:55,532,394...55,533,092

NUP214

nucleoporin 214

ISO

PID

PID:200144

NCBI chr 9:102,246,575...102,355,291
Ensembl chr 9:130,893,110...131,001,305

PPM1A

protein phosphatase, Mg2+/Mn2+ dependent 1A

ISO

PID

PID:200144

NCBI chr14:40,853,227...40,906,044
Ensembl chr14:59,117,020...59,162,928

PPP1CA

protein phosphatase 1 catalytic subunit alpha

ISO

PID

PID:200144

NCBI chr11:62,756,659...62,760,369
Ensembl chr11:66,068,007...66,071,611

PPP1R15A

protein phosphatase 1 regulatory subunit 15A

ISO

PID

PID:200144

NCBI chr19:45,872,596...45,876,376
Ensembl chr19:54,880,141...54,883,003

RGMA

repulsive guidance molecule BMP co-receptor a

ISO

PID

PID:200144

NCBI chr15:71,728,669...71,774,447
Ensembl chr15:90,922,199...90,956,179

RGMB

repulsive guidance molecule BMP co-receptor b

ISO

PID

PID:200144

NCBI chr 5:94,080,200...94,107,441
Ensembl chr 5:99,639,527...99,661,904

SKI

SKI proto-oncogene

ISO

PID

PID:200144

NCBI chr 1:944,428...1,029,695
Ensembl chr 1:2,091,620...2,174,080

SLC39A13

solute carrier family 39 member 13

NCBI chr11:47,356,465...47,364,710
Ensembl chr11:47,910,551...47,918,014

SMAD1

SMAD family member 1

ISO

RGD
PID

PMID:16361357 PMID:18985159

PID:200144 RGD:11553861 RGD:1580077

NCBI chr 4:137,822,269...137,899,700
Ensembl chr 4:149,481,836...149,558,135

SMAD4

SMAD family member 4

ISO

PID

PID:200144

NCBI chr18:44,402,112...44,456,779
Ensembl chr18:47,764,568...47,797,359

SMAD5

SMAD family member 5

ISO

RGD
PID

PMID:16361357 PMID:18985159

PID:200144 RGD:11553861 RGD:1580077

NCBI chr 5:131,524,229...131,574,119
Ensembl chr 5:137,664,067...137,712,635

SMAD6

SMAD family member 6

ISO

PID

PID:200144

NCBI chr15:45,648,709...45,728,821
Ensembl chr15:63,923,379...64,001,154

SMAD7

SMAD family member 7

ISO

PID

PID:200144

NCBI chr18:42,306,324...42,337,214

SMAD family member 9

PID:200144 RGD:1580077

NCBI chr13:18,055,427...18,130,571
Ensembl chr13:36,486,597...36,521,646

SMURF1

SMAD specific E3 ubiquitin protein ligase 1

ISO

PID

PID:200144

NCBI chr 7:90,995,923...91,112,240
Ensembl chr 7:104,500,965...104,568,046

SMURF2

SMAD specific E3 ubiquitin protein ligase 2

ISO

PID

PID:200144

NCBI chr17:58,638,995...58,759,443
Ensembl chr17:63,731,386...63,809,298

SOSTDC1

sclerostin domain containing 1

ISO

PID

PID:200144

NCBI chr 7:17,193,531...17,229,769
Ensembl chr 7:16,443,703...16,448,076
Ensembl chr 7:16,443,703...16,448,076

TAB1

TGF-beta activated kinase 1 (MAP3K7) binding protein 1

ISO

PID

PID:200144

NCBI chr22:20,303,547...20,343,314
Ensembl chr22:38,122,835...38,162,705

TAB2

TGF-beta activated kinase 1 (MAP3K7) binding protein 2

ISO

PID

PID:200144

NCBI chr 6:147,138,553...147,231,559
Ensembl chr 6:151,868,513...151,936,841

XIAP

X-linked inhibitor of apoptosis

ISO

PID

PID:200144

NCBI chr X:113,052,164...113,105,160
Ensembl chr X:123,232,643...123,278,606

ZFYVE16

zinc finger FYVE-type containing 16

ISO

PID

PID:200144

NCBI chr 5:34,837,410...34,910,416
Ensembl chr 5:35,111,723...35,183,028

brain natriuretic peptide signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

NPPB

natriuretic peptide B

NCBI chr 1:10,621,416...10,622,960
Ensembl chr 1:11,838,518...11,839,995

NPR1

natriuretic peptide receptor 1

NCBI chr 1:129,034,972...129,050,439
Ensembl chr 1:132,664,948...132,679,327

brain-derived neurotrophic factor signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BDNF

brain derived neurotrophic factor

NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239

FRS2

fibroblast growth factor receptor substrate 2

NCBI chr12:66,992,207...67,107,313
Ensembl chr12:69,829,435...69,878,293

GRB2

growth factor receptor bound protein 2

NCBI chr17:69,265,307...69,352,835
Ensembl chr17:74,817,471...74,903,796

NTRK2

neurotrophic receptor tyrosine kinase 2

NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678

SHC1

SHC adaptor protein 1

NCBI chr 1:130,310,778...130,323,001
Ensembl chr 1:133,920,532...133,929,008

TIAM1

TIAM Rac1 associated GEF 1

NCBI chr21:17,483,273...17,925,301
Ensembl chr21:30,868,308...31,016,883

c-Jun N-terminal kinases MAPK signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CDC42

cell division cycle 42

ISO

RGD

PMID:8910292 PMID:9305638

RGD:2293876 RGD:2293879

NCBI chr 1:21,245,970...21,286,210

DUSP1

dual specificity phosphatase 1

NCBI chr 5:168,121,536...168,124,671
Ensembl chr 5:175,032,803...175,035,960

DUSP10

dual specificity phosphatase 10

NCBI chr 1:197,293,039...197,333,828
Ensembl chr 1:202,367,318...202,404,720

DUSP16

dual specificity phosphatase 16

NCBI chr12:12,497,185...12,585,591
Ensembl chr12:12,865,400...12,912,502

DUSP19

dual specificity phosphatase 19

NCBI chr2B:70,347,712...70,371,852
Ensembl chr2B:188,157,061...188,178,266

DUSP8

dual specificity phosphatase 8

NCBI chr11:1,592,858...1,611,740

MAP2K4

mitogen-activated protein kinase kinase 4

ISO

RGD

PMID:10051439 PMID:17064355 PMID:17306896

RGD:2293875 RGD:2298561 RGD:2298577

NCBI chr17:39,497,105...39,622,331
Ensembl chr17:44,248,857...44,359,909

MAP2K7

mitogen-activated protein kinase kinase 7

ISO

RGD

PMID:10051439 PMID:15680699 PMID:17064355 PMID:17306896

RGD:2293875 RGD:2298561 RGD:2298567 RGD:2298577

NCBI chr19:7,205,124...7,215,776
Ensembl chr19:8,057,598...8,066,512

MAP3K1

mitogen-activated protein kinase kinase kinase 1

ISO

RGD

PMID:9305638 PMID:17306896

RGD:2293875 RGD:2293879

NCBI chr 5:57,116,405...57,197,017
Ensembl chr 5:58,745,579...58,826,959

MAP3K10

mitogen-activated protein kinase kinase kinase 10

NCBI chr19:37,236,438...37,260,314
Ensembl chr19:45,753,354...45,775,137

MAP3K11

mitogen-activated protein kinase kinase kinase 11

ISO

RGD

PMID:8910292 PMID:15680699 PMID:17064355 PMID:17306896

RGD:2293875 RGD:2293876 RGD:2298567 RGD:2298577

NCBI chr11:60,956,880...60,973,972
Ensembl chr11:64,291,635...64,307,737

MAP3K12

mitogen-activated protein kinase kinase kinase 12

NCBI chr12:35,253,814...35,273,739
Ensembl chr12:36,038,634...36,058,200

MAP3K13

mitogen-activated protein kinase kinase kinase 13

NCBI chr 3:182,319,405...182,517,655
Ensembl chr 3:190,798,694...190,993,633

MAP3K2

mitogen-activated protein kinase kinase kinase 2

ISO

RGD

PMID:9305638 PMID:17306896

RGD:2293875 RGD:2293879

NCBI chr2B:32,889,499...32,979,077
Ensembl chr2B:127,972,900...128,008,766

MAP3K20

mitogen-activated protein kinase kinase kinase 20

NCBI chr2B:60,362,635...60,555,445
Ensembl chr2B:177,818,344...178,010,556

MAP3K21

mitogen-activated protein kinase kinase kinase 21

NCBI chr 1:208,861,949...208,920,381

MAP3K3

mitogen-activated protein kinase kinase kinase 3

ISO

RGD

PMID:9305638 PMID:17306896

RGD:2293875 RGD:2293879

NCBI chr17:57,702,242...57,776,601
Ensembl chr17:62,858,635...62,922,874

MAP3K4

mitogen-activated protein kinase kinase kinase 4

ISO

RGD

PMID:9305638 PMID:17306896

RGD:2293875 RGD:2293879

NCBI chr 6:158,937,424...159,062,550
Ensembl chr 6:163,948,122...164,073,264

MAP3K5

mitogen-activated protein kinase kinase kinase 5

ISO

RGD

PMID:12215209 PMID:17306896

RGD:2293875 RGD:2296020

NCBI chr 6:134,316,841...134,582,843
Ensembl chr 6:138,406,398...138,641,727

MAP3K7

mitogen-activated protein kinase kinase kinase 7

NCBI chr 6:88,398,329...88,470,926
Ensembl chr 6:91,664,263...91,737,468

MAP3K9

mitogen-activated protein kinase kinase kinase 9

NCBI chr14:51,310,565...51,396,994
Ensembl chr14:70,188,444...70,266,460

MAPK10

mitogen-activated protein kinase 10

ISO

RGD

PMID:10051439 PMID:15680699 PMID:17306896

RGD:2293875 RGD:2298561 RGD:2298567

NCBI chr 4:78,326,129...78,756,794
Ensembl chr 4:89,059,579...89,392,196

MAPK8

mitogen-activated protein kinase 8

ISO

RGD

PMID:10051439 PMID:17064355 PMID:17306896

RGD:2293875 RGD:2298561 RGD:2298577

NCBI chr10:45,806,748...45,936,362

MAPK8IP1

mitogen-activated protein kinase 8 interacting protein 1

ISO

RGD

PMID:15816852 PMID:17726577

RGD:1579811 RGD:2293880

NCBI chr11:45,839,754...45,860,615
Ensembl chr11:46,332,159...46,352,010

MAPK8IP2

mitogen-activated protein kinase 8 interacting protein 2

NCBI chr22:30,846,613...30,857,737
Ensembl chr22:49,957,769...49,966,986

MAPK8IP3

mitogen-activated protein kinase 8 interacting protein 3

NCBI chr16:327,995...392,691
Ensembl chr16:1,759,171...1,821,246

MAPK9

mitogen-activated protein kinase 9

ISO

RGD

PMID:10051439 PMID:17064355 PMID:17306896

RGD:2293875 RGD:2298561 RGD:2298577

NCBI chr 5:175,437,167...175,495,469
Ensembl chr 5:182,748,381...182,795,135

RAC1

Rac family small GTPase 1

ISO

RGD

PMID:8910292 PMID:9305638

RGD:2293876 RGD:2293879

NCBI chr 7:7,039,379...7,068,866

RAPGEF1

Rap guanine nucleotide exchange factor 1

NCBI chr 9:102,698,970...102,861,482
Ensembl chr 9:131,337,001...131,495,664

SPP1

secreted phosphoprotein 1

NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935

TRAF2

TNF receptor associated factor 2

NCBI chr 9:107,938,935...107,984,797
Ensembl chr 9:136,917,358...136,955,331

C-type natriuretic peptide signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

NPPC

natriuretic peptide C

ISO

RGD

PMID:15337698 PMID:16537417

RGD:1580149 RGD:1601488

NCBI chr2B:119,148,774...119,153,381
Ensembl chr2B:237,936,939...237,941,244

NPR2

natriuretic peptide receptor 2

NCBI chr 9:35,642,534...35,660,210
Ensembl chr 9:36,445,576...36,462,637

NPR3

natriuretic peptide receptor 3

NCBI chr 5:77,542,200...77,621,983
Ensembl chr 5:82,926,409...83,004,964

cadherin mediated signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

cadherin 2

NCBI chr18:21,210,001...21,435,919
Ensembl chr18:24,812,019...25,008,325

calcineurin signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

NFATC2

nuclear factor of activated T cells 2

NCBI chr20:47,734,054...47,910,435
Ensembl chr20:48,858,238...49,034,007

NFATC3

nuclear factor of activated T cells 3

NCBI chr16:48,456,144...48,603,306
Ensembl chr16:67,888,806...67,996,274

NFATC4

nuclear factor of activated T cells 4

NCBI chr14:5,141,699...5,156,021
Ensembl chr14:23,266,702...23,279,249

PPP3CA

protein phosphatase 3 catalytic subunit alpha

NCBI chr 4:93,447,095...93,770,339
Ensembl chr 4:104,113,520...104,435,394

PPP3CB

protein phosphatase 3 catalytic subunit beta

NCBI chr10:69,984,241...70,043,352
Ensembl chr10:72,443,051...72,501,752

PPP3CC

protein phosphatase 3 catalytic subunit gamma

NCBI chr 8:21,690,598...21,791,335
Ensembl chr 8:18,629,261...18,729,995

PPP3R1

protein phosphatase 3 regulatory subunit B, alpha

NCBI chr2A:68,227,282...68,300,482

PPP3R2

protein phosphatase 3 regulatory subunit B, beta

NCBI chr 9:72,796,099...72,799,499

RCAN1

regulator of calcineurin 1

NCBI chr21:20,889,123...20,987,964
Ensembl chr21:34,258,355...34,267,025

calcium signaling pathway via the calcium-sensing receptor

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ARRB1

arrestin beta 1

ISO

RGD

PMID:15637145 PMID:22192592

RGD:7207059 RGD:7207060

NCBI chr11:70,319,935...70,411,276
Ensembl chr11:73,630,276...73,654,155

ARRB2

arrestin beta 2

ISO

RGD

PMID:15637145 PMID:22192592

RGD:7207059 RGD:7207060

NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517

CASR

calcium sensing receptor

ISO

RGD

PMID:12239094 PMID:15637145 PMID:22192592

RGD:7207059 RGD:7207060 RGD:7207227

NCBI chr 3:119,278,071...119,383,901
Ensembl chr 3:126,252,765...126,285,268

filamin A

NCBI chr X:143,799,088...143,825,282

GRK2

G protein-coupled receptor kinase 2

NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066

GRK3

G protein-coupled receptor kinase 3

NCBI chr22:6,579,664...6,789,846
Ensembl chr22:24,353,533...24,509,560

GRK4

G protein-coupled receptor kinase 4

NCBI chr 4:3,106,064...3,181,270
Ensembl chr 4:3,008,126...3,083,094

RGS12

regulator of G protein signaling 12

NCBI chr 4:3,439,030...3,589,026
Ensembl chr 4:3,444,570...3,573,712

RGS2

regulator of G protein signaling 2

NCBI chr 1:168,273,112...168,276,348
Ensembl chr 1:172,566,701...172,569,955

RGS4

regulator of G protein signaling 4

NCBI chr 1:138,488,317...138,496,497
Ensembl chr 1:142,284,040...142,292,225

RGS5

regulator of G protein signaling 5

NCBI chr 1:138,561,940...138,622,698
Ensembl chr 1:142,362,663...142,387,291

RHOA

ras homolog family member A

NCBI chr 3:49,282,009...49,339,887

calcium/calcium-mediated signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ATP2A1

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

Ensembl chr16:29,265,516...29,290,807
Ensembl chr16:29,265,516...29,290,807

ATP2A2

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

NCBI chr12:107,857,009...107,924,938
Ensembl chr12:111,246,508...111,311,923

ATP2A3

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

NCBI chr17:3,992,088...4,013,998
Ensembl chr17:3,965,925...3,998,382

ATP2B1

ATPase plasma membrane Ca2+ transporting 1

NCBI chr12:87,107,900...87,229,514
Ensembl chr12:90,427,560...90,495,320

ATP2B2

ATPase plasma membrane Ca2+ transporting 2

NCBI chr 3:10,260,556...10,643,346
Ensembl chr 3:10,611,619...10,738,006

ATP2B3

ATPase plasma membrane Ca2+ transporting 3

NCBI chr X:143,068,171...143,133,479
Ensembl chr X:152,955,109...153,019,445

ATP2B4

ATPase plasma membrane Ca2+ transporting 4

NCBI chr 1:179,231,712...179,348,759
Ensembl chr 1:183,580,773...183,639,882

ATP2C1

ATPase secretory pathway Ca2+ transporting 1

NCBI chr 3:127,937,272...128,101,060
Ensembl chr 3:135,260,796...135,423,700

ATP2C2

ATPase secretory pathway Ca2+ transporting 2

NCBI chr16:65,033,470...65,127,403
Ensembl chr16:84,375,658...84,468,671

CABP1

calcium binding protein 1

NCBI chr12:118,224,046...118,250,696

CABP2

calcium binding protein 2

NCBI chr11:62,877,978...62,882,653

CABP4

calcium binding protein 4

NCBI chr11:62,813,477...62,820,425
Ensembl chr11:66,121,992...66,128,758

CACNA1A

calcium voltage-gated channel subunit alpha1 A

NCBI chr19:12,769,586...13,189,022
Ensembl chr19:13,507,102...13,804,729

CACNA1B

calcium voltage-gated channel subunit alpha1 B

NCBI chr 9:108,989,621...109,256,841

CACNA1C

calcium voltage-gated channel subunit alpha1 C

NCBI chr12:2,166,672...2,817,827
Ensembl chr12:2,114,140...2,744,826

CACNA1D

calcium voltage-gated channel subunit alpha1 D

NCBI chr 3:53,432,189...53,751,347
Ensembl chr 3:54,495,952...54,970,444

CACNA1E

calcium voltage-gated channel subunit alpha1 E

NCBI chr 1:156,796,855...157,296,987
Ensembl chr 1:160,628,089...160,949,270

CACNA1F

calcium voltage-gated channel subunit alpha1 F

NCBI chr X:41,504,804...41,533,501
Ensembl chr X:49,356,994...49,385,678

CACNA1G

calcium voltage-gated channel subunit alpha1 G

NCBI chr17:44,654,558...44,786,037
Ensembl chr17:49,529,402...49,595,166
Ensembl chr17:49,529,402...49,595,166

CACNA1H

calcium voltage-gated channel subunit alpha1 H

Ensembl chr16:1,195,364...1,222,917

CACNA1I

calcium voltage-gated channel subunit alpha1 I

NCBI chr22:20,463,511...20,595,253
Ensembl chr22:38,296,436...38,414,963

CACNA1S

calcium voltage-gated channel subunit alpha1 S

NCBI chr 1:176,639,189...176,712,171
Ensembl chr 1:180,941,836...181,014,823

CACNB1

calcium voltage-gated channel auxiliary subunit beta 1

NCBI chr17:18,073,818...18,098,400
Ensembl chr17:18,349,146...18,373,338

CACNB2

calcium voltage-gated channel auxiliary subunit beta 2

NCBI chr10:18,459,528...18,862,495
Ensembl chr10:18,795,832...19,195,226

CACNB3

calcium voltage-gated channel auxiliary subunit beta 3

NCBI chr12:39,918,022...39,931,386
Ensembl chr12:40,797,293...40,811,409

CACNB4

calcium voltage-gated channel auxiliary subunit beta 4

NCBI chr2B:39,137,777...39,399,007
Ensembl chr2B:156,379,469...156,639,328

calbindin 1

NCBI chr 8:86,747,702...86,771,995
Ensembl chr 8:88,699,532...88,723,814

calbindin 2

NCBI chr16:53,620,317...53,653,372
Ensembl chr16:71,195,770...71,227,937

CALM1

calmodulin 1

ISO

RGD

PMID:10884684 PMID:18083096

RGD:7204676 RGD:7204677

NCBI chr14:71,015,099...71,026,322
Ensembl chr19:52,121,687...52,131,135

CALM2

calmodulin 2

ISO

RGD

PMID:10884684 PMID:18083096

RGD:7204676 RGD:7204677

NCBI chr2A:47,274,722...47,290,861
Ensembl chr2A:48,204,518...48,220,697

CALM3

calmodulin 3

ISO

RGD

PMID:10884684 PMID:18083096

RGD:7204676 RGD:7204677

NCBI chr19:43,593,069...43,602,550
Ensembl chr19:52,121,687...52,131,135

calreticulin

NCBI chr19:12,501,013...12,506,909
Ensembl chr19:13,242,900...13,249,416

calsequestrin 1

NCBI chr 1:135,544,249...135,555,545
Ensembl chr 1:139,465,605...139,476,969

calsequestrin 2

NCBI chr 1:86,795,392...86,864,196
Ensembl chr 1:121,844,097...121,913,311

CIMIP3

ciliary microtubule inner protein 3

NCBI chr 6:41,743,396...41,751,883
Ensembl chr 6:43,045,307...43,053,377

CNGA1

cyclic nucleotide gated channel subunit alpha 1

NCBI chr 4:74,196,877...74,213,563
Ensembl chr 4:84,910,653...84,945,248

CNGA2

cyclic nucleotide gated channel subunit alpha 2

NCBI chr X:141,315,052...141,324,754
Ensembl chr X:151,275,800...151,281,909

CNGA3

cyclic nucleotide gated channel subunit alpha 3

NCBI chr2A:100,911,053...100,962,278
Ensembl chr2A:99,259,808...99,308,517

CNGA4

cyclic nucleotide gated channel subunit alpha 4

NCBI chr11:6,368,768...6,378,976
Ensembl chr11:6,051,091...6,061,550

CNGB1

cyclic nucleotide gated channel subunit beta 1

NCBI chr16:38,160,056...38,249,474
Ensembl chr16:57,292,093...57,375,460

CNGB3

cyclic nucleotide gated channel subunit beta 3

NCBI chr 8:83,269,589...83,439,999
Ensembl chr 8:85,238,043...85,407,059

GUCA1B

guanylate cyclase activator 1B

NCBI chr 6:41,771,537...41,783,364
Ensembl chr 6:43,072,469...43,083,838

GUCA2B

guanylate cyclase activator 2B

NCBI chr 1:41,452,722...41,455,192
Ensembl chr 1:42,832,196...42,835,425

ITPR1

inositol 1,4,5-trisphosphate receptor type 1

NCBI chr 3:4,448,574...4,802,545
Ensembl chr 3:4,572,921...4,904,811

ITPR2

inositol 1,4,5-trisphosphate receptor type 2

NCBI chr12:59,478,206...59,984,572
Ensembl chr12:62,092,241...62,596,018

ITPR3

inositol 1,4,5-trisphosphate receptor type 3

NCBI chr 6:33,194,531...33,269,788
Ensembl chr 6:34,303,454...34,378,215

KCNIP1

potassium voltage-gated channel interacting protein 1

NCBI chr 5:165,711,110...166,095,049
Ensembl chr 5:172,622,331...172,853,992

KCNIP2

potassium voltage-gated channel interacting protein 2

NCBI chr10:98,428,619...98,446,581
Ensembl chr10:101,899,898...101,918,691

KCNIP3

potassium voltage-gated channel interacting protein 3

NCBI chr2A:104,018,539...104,111,126
Ensembl chr2A:96,200,412...96,291,374

KCNIP4

potassium voltage-gated channel interacting protein 4

NCBI chr 4:15,131,693...16,354,827
Ensembl chr 4:20,422,728...21,645,866

KCNN1

potassium calcium-activated channel subfamily N member 1

NCBI chr19:17,430,795...17,478,981
Ensembl chr19:18,422,231...18,458,630

KCNN2

potassium calcium-activated channel subfamily N member 2

NCBI chr 5:109,722,916...109,862,747
Ensembl chr 5:115,522,443...115,661,079

KCNN3

potassium calcium-activated channel subfamily N member 3

NCBI chr 1:130,052,903...130,218,977
Ensembl chr 1:133,666,876...133,828,366

KCNN4

potassium calcium-activated channel subfamily N member 4

NCBI chr19:40,715,621...40,735,025
Ensembl chr19:49,321,403...49,335,900

LOC100990398

transient receptor potential cation channel subfamily V member 6

NCBI chr 7:134,862,223...134,877,051
Ensembl chr 7:147,353,684...147,368,475

MCOLN1

mucolipin TRP cation channel 1

NCBI chr19:6,813,498...6,825,153
Ensembl chr19:7,671,704...7,683,093

MCU

mitochondrial calcium uniporter

NCBI chr10:69,243,282...69,435,193
Ensembl chr10:71,845,335...71,898,545

NCS1

neuronal calcium sensor 1

NCBI chr 9:101,299,724...101,364,897
Ensembl chr 9:129,950,921...130,016,257

oncomodulin

NCBI chr 7:6,066,257...6,126,400

ORAI1

ORAI calcium release-activated calcium modulator 1

NCBI chr12:119,229,069...119,243,435

ORAI2

ORAI calcium release-activated calcium modulator 2

NCBI chr 7:94,573,923...94,592,028

ORAI3

ORAI calcium release-activated calcium modulator 3

NCBI chr16:24,014,018...24,019,889
Ensembl chr16:31,314,922...31,323,320

parvalbumin

NCBI chr22:17,715,109...17,731,587
Ensembl chr22:35,551,448...35,568,316

recoverin

NCBI chr17:41,747,255...41,759,074
Ensembl chr17:46,490,605...46,502,962

ryanodine receptor 1

NCBI chr19:35,527,466...35,685,446
Ensembl chr19:44,106,036...44,256,327

ryanodine receptor 2

NCBI chr 1:212,600,198...213,387,312
Ensembl chr 1:217,815,676...218,383,509

ryanodine receptor 3

NCBI chr15:11,816,430...12,379,101
Ensembl chr15:30,817,428...31,214,494

S100A1

S100 calcium binding protein A1

ISO

RGD

PMID:16129693 PMID:17964289

RGD:1579960 RGD:7204682

NCBI chr 1:128,984,296...128,987,979

S100A4

S100 calcium binding protein A4

NCBI chr 1:128,898,765...128,901,042
Ensembl chr 1:132,527,846...132,530,122

S100B

S100 calcium binding protein B

NCBI chr21:33,063,845...33,070,073
Ensembl chr21:46,197,750...46,203,953

S100G

S100 calcium binding protein G

NCBI chr X:9,272,311...9,276,147
Ensembl chr X:16,642,211...16,645,760

SLC24A1

solute carrier family 24 member 1

NCBI chr15:44,552,886...44,597,640
Ensembl chr15:62,831,987...62,882,431

SLC24A2

solute carrier family 24 member 2

NCBI chr 9:19,317,132...19,593,503
Ensembl chr 9:19,814,244...20,249,225

SLC24A3

solute carrier family 24 member 3

NCBI chr20:19,168,820...19,680,706
Ensembl chr20:19,137,938...19,646,475

SLC24A4

solute carrier family 24 member 4

NCBI chr14:72,956,230...73,128,851
Ensembl chr14:92,299,507...92,468,939

SLC24A5

solute carrier family 24 member 5

NCBI chr15:27,069,937...27,091,619
Ensembl chr15:45,394,090...45,415,823

SLC8A1

solute carrier family 8 member A1

NCBI chr2A:40,169,339...40,586,546
Ensembl chr2A:40,939,900...41,363,038

SLC8A2

solute carrier family 8 member A2

NCBI chr19:44,420,146...44,464,242
Ensembl chr19:53,077,857...53,113,830

SLC8A3

solute carrier family 8 member A3

NCBI chr14:50,634,091...50,779,712

SLC8B1

solute carrier family 8 member B1

NCBI chr12:110,903,215...110,936,908
Ensembl chr12:114,286,624...114,319,683

STIM1

stromal interaction molecule 1

NCBI chr11:3,726,501...3,954,951
Ensembl chr11:3,840,513...4,065,224

STIM2

stromal interaction molecule 2

NCBI chr 4:21,262,272...21,424,944
Ensembl chr 4:26,537,703...26,694,416

SYT1

synaptotagmin 1

ISO

RGD

PMID:11751925 PMID:15534041

RGD:2311146 RGD:7204679

NCBI chr12:76,392,955...76,981,800
Ensembl chr12:79,595,704...79,829,923

SYT7

synaptotagmin 7

ISO

RGD

PMID:15534041 PMID:18713958

RGD:2311148 RGD:7204679

NCBI chr11:56,814,694...56,880,439
Ensembl chr11:60,175,403...60,242,375

SYT9

synaptotagmin 9

ISO

RGD

PMID:11751925 PMID:18713958

RGD:2311146 RGD:2311148

NCBI chr11:7,350,612...7,565,272
Ensembl chr11:7,032,803...7,247,187

TNNC1

troponin C1, slow skeletal and cardiac type

NCBI chr 3:52,393,106...52,396,076
Ensembl chr 3:53,621,749...53,624,726

TNNC2

troponin C2, fast skeletal type

NCBI chr20:42,162,502...42,172,829
Ensembl chr20:43,249,725...43,254,134

TPCN1

two pore segment channel 1

NCBI chr12:110,812,587...110,903,033
Ensembl chr12:114,209,638...114,286,443

TPCN2

two pore segment channel 2

NCBI chr11:64,139,512...64,227,913
Ensembl chr11:67,438,635...67,478,106

calcium/calmodulin dependent kinase 2 signaling pathway

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CACNA1C

calcium voltage-gated channel subunit alpha1 C

NCBI chr12:2,166,672...2,817,827
Ensembl chr12:2,114,140...2,744,826

CACNB2

calcium voltage-gated channel auxiliary subunit beta 2

NCBI chr10:18,459,528...18,862,495
Ensembl chr10:18,795,832...19,195,226

CACNG2

calcium voltage-gated channel auxiliary subunit gamma 2

NCBI chr22:17,475,693...17,618,299
Ensembl chr22:35,317,121...35,454,850

CALM1

calmodulin 1

ISO

RGD

PMID:22717267 PMID:23091085

RGD:7240705 RGD:7240708

NCBI chr14:71,015,099...71,026,322
Ensembl chr19:52,121,687...52,131,135

CALM2

calmodulin 2

ISO

RGD

PMID:22717267 PMID:23091085

RGD:7240705 RGD:7240708

NCBI chr2A:47,274,722...47,290,861
Ensembl chr2A:48,204,518...48,220,697

CALM3

calmodulin 3

ISO

RGD

PMID:22717267 PMID:23091085

RGD:7240705 RGD:7240708

NCBI chr19:43,593,069...43,602,550
Ensembl chr19:52,121,687...52,131,135

CAMK2A

calcium/calmodulin dependent protein kinase II alpha

ISO

RGD

PMID:22334212 PMID:22717267

RGD:7240704 RGD:7240705

NCBI chr 5:145,644,164...145,714,143
Ensembl chr 5:151,649,062...151,719,373

CAMK2B

calcium/calmodulin dependent protein kinase II beta

ISO

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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PATHWAY ONTOLOGY - ANNOTATIONS