PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: methotrexate pharmacodynamics pathway
Accession: PW:0000932
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Definition: The pathway of methotrexate-target interaction and of the biochemical or physiological responses to drug. The impact of MTX on cancer and rheumatoid arthritis is thought to arise through distinct mechanisms and pharmacodynamics pathways. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms: related_synonym: MTX pharmacodynamics pathway; SMP:00432
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Aldh1l1
aldehyde dehydrogenase 1 family, member L1
ISO
SMPDB
SMP:00432
NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465
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Dhfr
dihydrofolate reductase
ISO
SMPDB
SMP:00432
NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
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Fpgs
folylpolyglutamate synthase
ISO
SMPDB
SMP:00432
NCBI chr 3:15,972,800...15,993,592
Ensembl chr 3:15,972,800...15,993,563
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Ftcd
formimidoyltransferase cyclodeaminase
ISO
SMPDB
SMP:00432
NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735
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Ggh
gamma-glutamyl hydrolase
ISO
SMPDB
SMP:00432
NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787
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Mtfmt
mitochondrial methionyl-tRNA formyltransferase
ISO
SMPDB
SMP:00432
NCBI chr 8:65,953,787...65,971,841
Ensembl chr 8:65,953,767...65,971,841
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Mthfd1
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
ISO
SMPDB
SMP:00432
NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372
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Mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
ISO
SMPDB
SMP:00432
NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905
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Mthfd2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
ISO
SMPDB
SMP:00432
NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
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Mthfr
methylenetetrahydrofolate reductase
ISO
SMPDB
SMP:00432
NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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Mthfs
methenyltetrahydrofolate synthetase
ISO
SMPDB
SMP:00432
NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089
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Slc46a1
solute carrier family 46 member 1
ISO
SMPDB
SMP:00432
NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848
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