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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:ketone bodies biosynthetic pathway
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Accession:PW:0000776 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis of acetoacetate and beta-hydroxybutyrate, also known as ketone bodies, although only acetoacetate is a ketone. Generally, the acetyl-CoA derived from fatty acid oxidation enters the citrate cycle. In the liver, a substantial fraction of acetyl-CoA is converted to ketone bodies which are then released into the bloodstream to supply peripheral tissues.
Synonyms:related_synonym: Synthesis of Ketone Bodies;   ketone biosynthetic process


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ketone bodies biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 TAS RGD PMID:9893938 RGD:2326134 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 TAS RGD PMID:9893938 RGD:2326134 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    classic metabolic pathway 1854
      lipid metabolic pathway 488
        fatty acid metabolic pathway 191
          ketone bodies metabolic pathway 11
            ketone bodies biosynthetic pathway 2
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