Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:altered melanocortin system pathway
go back to main search page
Accession:PW:0000366 term browser browse the term
Definition:A melanocortin dependent system pathway that deviates from what its normal course should be. Mutations in the prohormone gene PMOC and the modifying enzyme PC1 are linked to obesity. Mutations in MC2R receptor and its accessory protein MRAP have been associated with type 1 and 2 familial glucocorticoid deficiency, respectively.


show annotations for term's descendants           Sort by:
altered melanocortin system pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGRP agouti related neuropeptide ISO RGD PMID:15189116 RGD:1357925 NCBI chr 5:81,924,249...81,926,510
Ensembl chr 5:81,925,055...81,925,845 		JBrowse link
G MC4R melanocortin 4 receptor ISO RGD PMID:15189116 RGD:1357925 NCBI chr 1:16,131,829...16,132,827
Ensembl chr 1:16,131,589...16,133,079 		JBrowse link
G PCSK1 proprotein convertase subtilisin/kexin type 1 ISO RGD PMID:11874690 PMID:15189116 RGD:1357925 RGD:1357926 NCBI chr 3:13,233,342...13,276,921
Ensembl chr 3:13,233,594...13,274,094 		JBrowse link
G POMC proopiomelanocortin ISO RGD PMID:11874690 PMID:15189116 RGD:1357925 RGD:1357926 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440 		JBrowse link
G SDC1 syndecan 1 ISO RGD PMID:15189116 RGD:1357925 NCBI chr17:15,220,906...15,243,974
Ensembl chr17:15,222,094...15,243,890 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4046
    regulatory pathway 2499
      homeostasis pathway 1305
        energy homeostasis pathway 236
          altered energy homeostasis pathway 12
            altered melanocortin system pathway 5
paths to the root