abnormal circulating CCL3 level - Ontology Report

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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:	abnormal circulating CCL3 level	go back to main search page
Accession:	MP:0031249	browse the term
Definition:	deviation from the normal blood levels of CCL3 protein, a chemokine that is secreted by a variety of hematopoietic and non-hematopoietic cells upon stimulation and plays a key role in recruiting inflammatory cells (macrophages, lymphocytes, eosinophils and basophils) to sites of injury or inflammation via the CCR1 or CCR5 receptor; it helps promote wound healing by recruiting macrophages to sites of tissue injury; acts as a potent osteoclast activator and induces bone resorption; exerts HIV-suppressive activity; and inhibits hematopoietic stem cell proliferation
Synonyms:	exact_synonym:	abnormal circulating C-C motif chemokine 3 level; abnormal circulating MIP-1 alpha level; abnormal circulating MIP-1alpha level; abnormal circulating MIP1-alpha level; abnormal circulating MIP1A level; abnormal circulating macrophage inflammatory protein 1-alpha level

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Genes (1)

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ptgs2os

prostaglandin-endoperoxide synthase 2, opposite strand

NCBI chr 1:149,950,624...149,975,625
Ensembl chr 1:149,909,888...149,975,714

Term paths to the root

Path 1
Term	Annotations
mammalian phenotype	17088
immune system phenotype	5777
abnormal immune system physiology	3511
abnormal immune serum protein physiology	1486
abnormal cytokine level	609
abnormal chemokine level	107
abnormal circulating chemokine level	53
abnormal circulating CCL3 level	1
decreased circulating CCL3 level	1
increased circulating CCL3 level	0
Path 2
Term	Annotations
mammalian phenotype	17088
homeostasis/metabolism phenotype	7928
abnormal homeostasis	7062
abnormal protein level	2375
abnormal intercellular signaling peptide or protein level	624
abnormal cytokine level	609
abnormal chemokine level	107
abnormal CCL3 level	1
abnormal circulating CCL3 level	1
decreased circulating CCL3 level	1
increased circulating CCL3 level	0

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