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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:increased CCL3 level
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Accession:MP:0031248 term browser browse the term
Definition:increase in the amount of CCL3 protein, a chemokine that is secreted by a variety of hematopoietic and non-hematopoietic cells upon stimulation and plays a key role in recruiting inflammatory cells (macrophages, lymphocytes, eosinophils and basophils) to sites of injury or inflammation via the CCR1 or CCR5 receptor; it helps promote wound healing by recruiting macrophages to sites of tissue injury; acts as a potent osteoclast activator and induces bone resorption; exerts HIV-suppressive activity; and inhibits hematopoietic stem cell proliferation
Synonyms:exact_synonym: increased C-C motif chemokine 3 level;   increased MIP-1 alpha level;   increased MIP-1alpha level;   increased MIP1-alpha level;   increased MIP1A level;   increased macrophage inflammatory protein 1-alpha level



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increased circulating CCL3 level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja8 gap junction protein, alpha 8 IAGP RGD PMID:27871290 RGD:150429989 NCBI chr 2:184,490,840...184,492,456
Ensembl chr 2:184,490,840...184,492,456
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G Gja8m1Cub gap junction protein, alpha 8; mutant 1 Cub IAGP RGD PMID:27871290 RGD:150429989

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5420
    immune system phenotype 519
      abnormal immune system physiology 384
        abnormal immune serum protein physiology 92
          abnormal cytokine level 39
            abnormal chemokine level 7
              increased chemokine level 3
                increased CCL3 level 3
                  increased circulating CCL3 level 3
Path 2
Term Annotations click to browse term
  mammalian phenotype 5420
    homeostasis/metabolism phenotype 1426
      abnormal homeostasis 1327
        abnormal protein level 137
          abnormal intercellular signaling peptide or protein level 43
            abnormal cytokine level 39
              abnormal chemokine level 7
                increased chemokine level 3
                  increased CCL3 level 3
                    increased circulating CCL3 level 3
paths to the root