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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased CCL3 level
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Accession:MP:0031248 term browser browse the term
Definition:increase in the amount of CCL3 protein, a chemokine that is secreted by a variety of hematopoietic and non-hematopoietic cells upon stimulation and plays a key role in recruiting inflammatory cells (macrophages, lymphocytes, eosinophils and basophils) to sites of injury or inflammation via the CCR1 or CCR5 receptor; it helps promote wound healing by recruiting macrophages to sites of tissue injury; acts as a potent osteoclast activator and induces bone resorption; exerts HIV-suppressive activity; and inhibits hematopoietic stem cell proliferation
Synonyms:exact_synonym: increased C-C motif chemokine 3 level;   increased MIP-1 alpha level;   increased MIP-1alpha level;   increased MIP1-alpha level;   increased MIP1A level;   increased macrophage inflammatory protein 1-alpha level


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Path 1
Term Annotations click to browse term
  mammalian phenotype 17065
    immune system phenotype 5763
      abnormal immune system physiology 3496
        abnormal immune serum protein physiology 1479
          abnormal cytokine level 606
            abnormal chemokine level 106
              increased chemokine level 15
                increased CCL3 level 0
                  increased circulating CCL3 level 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 17065
    homeostasis/metabolism phenotype 7909
      abnormal homeostasis 7051
        abnormal protein level 2371
          abnormal intercellular signaling peptide or protein level 621
            abnormal cytokine level 606
              abnormal chemokine level 106
                increased chemokine level 15
                  increased CCL3 level 0
                    increased circulating CCL3 level 0
paths to the root