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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:increased CCL3 level
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Accession:MP:0031248 term browser browse the term
Definition:increase in the amount of CCL3 protein, a chemokine that is secreted by a variety of hematopoietic and non-hematopoietic cells upon stimulation and plays a key role in recruiting inflammatory cells (macrophages, lymphocytes, eosinophils and basophils) to sites of injury or inflammation via the CCR1 or CCR5 receptor; it helps promote wound healing by recruiting macrophages to sites of tissue injury; acts as a potent osteoclast activator and induces bone resorption; exerts HIV-suppressive activity; and inhibits hematopoietic stem cell proliferation
Synonyms:exact_synonym: increased C-C motif chemokine 3 level;   increased MIP-1 alpha level;   increased MIP-1alpha level;   increased MIP1-alpha level;   increased MIP1A level;   increased macrophage inflammatory protein 1-alpha level



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Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 8
    immune system phenotype 0
      abnormal immune system physiology 0
        abnormal immune serum protein physiology 0
          abnormal cytokine level 0
            abnormal chemokine level 0
              increased chemokine level 0
                increased CCL3 level 0
                  increased circulating CCL3 level 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 8
    homeostasis/metabolism phenotype 0
      abnormal homeostasis 0
        abnormal protein level 0
          abnormal intercellular signaling peptide or protein level 0
            abnormal cytokine level 0
              abnormal chemokine level 0
                increased chemokine level 0
                  increased CCL3 level 0
                    increased circulating CCL3 level 0
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