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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:decreased CCL3 level
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Accession:MP:0031247 term browser browse the term
Definition:reduction in the amount of CCL3 protein, a chemokine that is secreted by a variety of hematopoietic and non-hematopoietic cells upon stimulation and plays a key role in recruiting inflammatory cells (macrophages, lymphocytes, eosinophils and basophils) to sites of injury or inflammation via the CCR1 or CCR5 receptor; it helps promote wound healing by recruiting macrophages to sites of tissue injury; acts as a potent osteoclast activator and induces bone resorption; exerts HIV-suppressive activity; and inhibits hematopoietic stem cell proliferation
Synonyms:exact_synonym: decreased C-C motif chemokine 3 level;   decreased MIP-1 alpha level;   decreased MIP-1alpha level;   decreased MIP1-alpha level;   decreased MIP1A level;   decreased macrophage inflammatory protein 1-alpha level;   reduced C-C motif chemokine 3 level;   reduced MIP-1 alpha level;   reduced MIP-1alpha level;   reduced MIP1-alpha level;   reduced MIP1A level;   reduced macrophage inflammatory protein 1-alpha level


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Path 1
Term Annotations click to browse term
  mammalian phenotype 5420
    immune system phenotype 519
      abnormal immune system physiology 384
        abnormal immune serum protein physiology 92
          abnormal cytokine level 39
            abnormal chemokine level 7
              decreased chemokine level 0
                decreased CCL3 level 0
                  decreased circulating CCL3 level 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5420
    homeostasis/metabolism phenotype 1426
      abnormal homeostasis 1327
        abnormal protein level 137
          abnormal intercellular signaling peptide or protein level 43
            abnormal cytokine level 39
              abnormal chemokine level 7
                decreased chemokine level 0
                  decreased CCL3 level 0
                    decreased circulating CCL3 level 0
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