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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased circulating angiotensin II level
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Accession:MP:0031232 term browser browse the term
Definition:increased concentration in the blood of angiotensin II, a vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; it acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone
Synonyms:exact_synonym: elevated circulating angiotensin II level
 narrow_synonym: increased plasma angiotensin II level;   increased serum angiotensin II level


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increased circulating angiotensin II level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 IAGP MGI PMID:16001071 PMID:16505206 PMID:16878172 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 IAGP MGI PMID:15731365 NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,467...74,728,167 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 IAGP MGI PMID:18945948 NCBI chr  X:52,076,955...52,110,537
Ensembl chr  X:52,077,014...52,110,536 		JBrowse link
G Hras Harvey rat sarcoma virus oncogene IAGP MGI PMID:18483625 NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 IAGP MGI PMID:9689096 NCBI chr 8:77,626,422...77,971,641
Ensembl chr 8:77,626,070...77,971,641 		JBrowse link
G Samd1 sterile alpha motif domain containing 1 IAGP MGI PMID:36810619 NCBI chr 8:84,724,145...84,727,044
Ensembl chr 8:84,724,130...84,727,038 		JBrowse link
G Vav3 vav 3 oncogene IAGP MGI PMID:16767097 NCBI chr 3:109,247,757...109,593,010
Ensembl chr 3:109,247,969...109,593,014 		JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor IAGP MGI PMID:12122115 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511 		JBrowse link
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Term Annotations click to browse term
  mammalian phenotype 17094
    homeostasis/metabolism phenotype 7946
      abnormal homeostasis 7072
        abnormal hormone level 1316
          abnormal circulating hormone level 1174
            increased circulating hormone level 732
              increased circulating angiotensin II level 8
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