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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:decreased circulating angiotensin II level
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Accession:MP:0031231 term browser browse the term
Definition:reduced concentration in the blood of angiotensin II, a vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; it acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone
Synonyms:exact_synonym: reduced circulating angiotensin II level
 narrow_synonym: decreased plasma angiotensin II level;   decreased serum angiotensin II level;   reduced plasma angiotensin II level;   reduced serum angiotensin II level


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decreased circulating angiotensin II level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IAGP MGI PMID:16001071 PMID:18158355 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Ace2 angiotensin converting enzyme 2 IAGP MGI PMID:16001071 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Acvrl1 activin A receptor, type II-like 1 IAGP MGI PMID:26398936 NCBI chr15:101,026,403...101,043,217
Ensembl chr15:101,026,403...101,043,217 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a IAGP MGI PMID:17607364 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
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  mammalian phenotype 17088
    homeostasis/metabolism phenotype 7927
      abnormal homeostasis 7061
        abnormal hormone level 1311
          abnormal circulating hormone level 1171
            decreased circulating hormone level 683
              decreased circulating angiotensin II level 4
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