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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal circulating troponin level
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Accession:MP:0031075 term browser browse the term
Definition:eviation from the normal concentration in the blood of troponin, a complex of three contractile regulatory proteins (troponin C, T and I) that control the calcium mediated interactions between actin and myosin in cardiac and skeletal muscles; in humans, cardiac-specific troponins I and T are regarded as the preferred biomarkers for the diagnosis of myocardial infarction due to their unique specificity for myocardial cell injury/necrosis


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decreased circulating troponin level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E IAGP MGI PMID:15031124 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Ldlr low density lipoprotein receptor IAGP MGI PMID:15031124 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
increased circulating troponin I level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tlr3 toll-like receptor 3 IAGP MGI PMID:16936008 NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117 		JBrowse link
increased circulating troponin T level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lamp2 lysosomal-associated membrane protein 2 IAGP MGI PMID:34459252 NCBI chr  X:37,488,524...37,545,337
Ensembl chr  X:37,490,234...37,545,331 		JBrowse link
G Yme1l1 YME1-like 1 (S. cerevisiae) IAGP MGI PMID:26785494 NCBI chr 2:23,046,517...23,089,272
Ensembl chr 2:23,046,381...23,089,272 		JBrowse link
Term paths to the root
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  mammalian phenotype 16965
    homeostasis/metabolism phenotype 7866
      abnormal homeostasis 7016
        abnormal blood homeostasis 5416
          abnormal circulating protein level 2157
            abnormal circulating troponin level 5
              decreased circulating troponin level 2
              increased circulating troponin level + 3
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