MAMMALIAN PHENOTYPE - ANNOTATIONS
The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term: increased lipid level
Accession: MP:0014460
browse the term
Definition: increase in the concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body
Synonyms: exact_synonym: elevated lipid concentration
G
Lepr
leptin receptor
IAGP
compared to heterozygous controls +/fa
RGD
PMID:11500530
RGD:628581
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
G
Leprfa
leptin receptor; fa mutant
IAGP
compared to heterozygous controls +/fa
RGD
PMID:11500530
RGD:628581
G
Ahr
aryl hydrocarbon receptor
sexual_dimorphism
IMP
females compared to Hsd:SD females
RGD
PMID:23859880
RGD:13204753
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Ahrem2Sage
aryl hydrocarbon receptor; ZFN induced mutant2, Sage
sexual_dimorphism
IMP
females compared to Hsd:SD females
RGD
PMID:23859880
RGD:13204753
G
Kit
KIT proto-oncogene receptor tyrosine kinase
IMP
RGD
PMID:7542218
RGD:12910748
NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
G
Apoe
apolipoprotein E
IMP
RGD
PMID:30796231
RGD:150521536
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
G
Bscl2
BSCL2 lipid droplet biogenesis associated, seipin
IMP
RGD
PMID:25934999
RGD:11085488
NCBI chr 1:205,731,828...205,743,430
Ensembl chr 1:205,733,872...205,743,421
G
Bscl2m1Kyo
BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo
IMP
RGD
PMID:25934999
RGD:11085488
G
Lamp2
lysosomal-associated membrane protein 2
IMP
in hemizygote mutant male (LAMP2y/-)
RGD
PMID:28124283
RGD:13703118
NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522
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Lamp2em1
lysosomal-associated membrane protein 2; TALEN induced mutant1
IMP
RGD
PMID:28124283
RGD:13703118
G
Lep
leptin
IMP
DNA:nonsense mutation:cds:
RGD
PMID:23800849
RGD:8549777
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
G
Lepm1Kyo
leptin; ENU induced mutant1, Kyo
IMP
RGD
PMID:23800849
RGD:8549777
G
Lepr
leptin receptor
disease_progression
IMP IAGP
DNA:mutations:cds: : (rat)
RGD
PMID:27225180 PMID:10901178 PMID:28746409 PMID:30278832 PMID:27465994 PMID:26537785 PMID:23154293 More...
RGD:12910507 , RGD:401965414 , RGD:401965413 , RGD:401960095 , RGD:12911217 , RGD:12911216 , RGD:13432147
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
G
Leprem2Mcwi
leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
disease_progression
IMP
RGD
PMID:27465994
RGD:12911217
G
Leprem3
leptin receptor; TALEN induced mutant 3
IMP
RGD
PMID:27225180
RGD:12910507
G
Leprem4Lizh
leptin receptor; CRISPR/Cas9 induced mutant 4, Lizh
IMP
compared to wild type littermate
RGD
PMID:26537785
RGD:12911216
G
Leprfa
leptin receptor; fa mutant
IAGP
RGD
PMID:23154293
RGD:13432147
G
Lrrk2
leucine-rich repeat kinase 2
IMP
RGD
PMID:24244710 PMID:23799078
RGD:12880447 , RGD:13462048
NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703
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Lrrk2em1Sage
leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
IMP
RGD
PMID:24244710
RGD:12880447
G
Mc4r
melanocortin 4 receptor
IMP
RGD
PMID:24400148
RGD:13825242
NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
G
Mc4rm1Hubr
melanocortin 4 receptor; ENU induced mutation 1, Hubr
IMP
RGD
PMID:24400148
RGD:13825242
G
Gck
glucokinase
IDA
overexpression sufficient to lower blood glucose significantly increased circulating FFA and TG levels (p<0.05)
RGD
PMID:10512368
RGD:2301945
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
G
Ldlr
low density lipoprotein receptor
IMP
RGD
PMID:28469073
RGD:12910100
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
G
Ldlrem1Sage
low density lipoprotein receptor; ZFN induced mutant 1, Sage
IMP
RGD
PMID:28469073
RGD:12910100
G
Mc4r
melanocortin 4 receptor
IMP
RGD
PMID:24400148
RGD:13825242
NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
G
Mc4rm1Hubr
melanocortin 4 receptor; ENU induced mutation 1, Hubr
IMP
RGD
PMID:24400148
RGD:13825242
G
Lep
leptin
IMP
RGD
PMID:22948215
RGD:12904911
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
G
Lepem1Sage
leptin; zinc finger nuclease induced mutant1, Sage
IMP
RGD
PMID:22948215
RGD:12904911
G
Lepr
leptin receptor
IMP
RGD
PMID:26537785
RGD:12911216
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
G
Leprem4Lizh
leptin receptor; CRISPR/Cas9 induced mutant 4, Lizh
IMP
compared to wild type littermate
RGD
PMID:26537785
RGD:12911216
G
Apoe
apolipoprotein E
IMP
RGD
PMID:30796231
RGD:150521536
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
G
Lep
leptin
IMP
RGD
PMID:22948215
RGD:12904911
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
G
Lepem1Sage
leptin; zinc finger nuclease induced mutant1, Sage
IMP
RGD
PMID:22948215
RGD:12904911
G
Lepr
leptin receptor
IMP
RGD
PMID:26537785
RGD:12911216
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
G
Leprem4Lizh
leptin receptor; CRISPR/Cas9 induced mutant 4, Lizh
IMP
compared to wild type littermate
RGD
PMID:26537785
RGD:12911216
G
Bscl2
BSCL2 lipid droplet biogenesis associated, seipin
IMP
RGD
PMID:25934999
RGD:11085488
NCBI chr 1:205,731,828...205,743,430
Ensembl chr 1:205,733,872...205,743,421
G
Bscl2m1Kyo
BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo
IMP
RGD
PMID:25934999
RGD:11085488
G
Gck
glucokinase
IDA
overexpression sufficient to lower blood glucose significantly increased circulating FFA and TG levels (p<0.05)
RGD
PMID:10512368
RGD:2301945
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
G
Gja8
gap junction protein, alpha 8
IAGP
RGD
PMID:27871290
RGD:150429989
NCBI chr 2:184,490,840...184,492,456
Ensembl chr 2:184,490,840...184,492,456
G
Gja8m1Cub
gap junction protein, alpha 8; mutant 1 Cub
IAGP
RGD
PMID:27871290
RGD:150429989
G
Lep
leptin
IMP
DNA:nonsense mutation:cds:
RGD
PMID:23800849
RGD:8549777
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
G
Lepm1Kyo
leptin; ENU induced mutant1, Kyo
IMP
RGD
PMID:23800849
RGD:8549777
G
Lepr
leptin receptor
treatment disease_progression
IMP IAGP
compared to ad lib fed rats
RGD
PMID:27225180 PMID:11500530 PMID:27465994 PMID:26537785
RGD:12910507 , RGD:628581 , RGD:12911217 , RGD:12911216
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
G
Leprem2Mcwi
leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
disease_progression
IMP
RGD
PMID:27465994
RGD:12911217
G
Leprem3
leptin receptor; TALEN induced mutant 3
IMP
RGD
PMID:27225180
RGD:12910507
G
Leprem4Lizh
leptin receptor; CRISPR/Cas9 induced mutant 4, Lizh
IMP
compared to wild type littermate
RGD
PMID:26537785
RGD:12911216
G
Leprfa
leptin receptor; fa mutant
treatment
IAGP
compared to ad lib fed rats
RGD
PMID:11500530
RGD:628581
G
Mc4r
melanocortin 4 receptor
IMP
RGD
PMID:24400148
RGD:13825242
NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
G
Mc4rm1Hubr
melanocortin 4 receptor; ENU induced mutation 1, Hubr
IMP
RGD
PMID:24400148
RGD:13825242
G
Nr4a1
nuclear receptor subfamily 4, group A, member 1
IMP
compared to FHH
RGD
PMID:24722447
RGD:12910103
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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Nr4a1m1Mcwi
nuclear receptor subfamily 4, group A, member 1; mutation 1, Medical College of Wisconsin
IMP
compared to FHH
RGD
PMID:24722447
RGD:12910103
G
Slc9a6
solute carrier family 9 member A6
IMP
RGD
PMID:34928329
RGD:151664747
NCBI chr X:134,430,677...134,486,747
Ensembl chr X:134,420,756...134,485,375
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Slc9a6 em1Moro
solute carrier family 9 member A6;CRISPR/Cas9 induced mutant1, Moro
IMP
RGD
PMID:34928329
RGD:151664747
G
Atp7b
ATPase copper transporting beta
IAGP
RGD
PMID:17303181
RGD:2292672
NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
G
Atp7bhts
ATPase copper transporting beta; hepatitis
IAGP
RGD
PMID:17303181
RGD:2292672
G
Ldlr
low density lipoprotein receptor
IMP
RGD
PMID:28469073
RGD:12910100
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
G
Ldlrem1Sage
low density lipoprotein receptor; ZFN induced mutant 1, Sage
IMP
RGD
PMID:28469073
RGD:12910100
G
Ldlr
low density lipoprotein receptor
IMP
RGD
PMID:27378433
RGD:12910104
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
G
Ldlrem1
low density lipoprotein receptor; ZFN induced mutant 1
IMP
RGD
PMID:27378433
RGD:12910104
G
Atp7b
ATPase copper transporting beta
IAGP
RGD
PMID:17303181
RGD:2292672
NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
G
Atp7bhts
ATPase copper transporting beta; hepatitis
IAGP
RGD
PMID:17303181
RGD:2292672
G
Bscl2
BSCL2 lipid droplet biogenesis associated, seipin
IMP
RGD
PMID:25934999
RGD:11085488
NCBI chr 1:205,731,828...205,743,430
Ensembl chr 1:205,733,872...205,743,421
G
Bscl2m1Kyo
BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo
IMP
RGD
PMID:25934999
RGD:11085488
G
Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
induces
IMP
compared to wild type
RGD
PMID:29656108
RGD:150520032
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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Cyp2j4em1Sage
cytochrome P450, family 2, subfamily j, polypeptide 4, ZFN induced mutant 1, Sage
induces
IMP
compared to wild type
RGD
PMID:29656108
RGD:150520032
G
Ldlr
low density lipoprotein receptor
IMP
RGD
PMID:28469073
RGD:12910100
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
G
Ldlrem1Sage
low density lipoprotein receptor; ZFN induced mutant 1, Sage
IMP
RGD
PMID:28469073
RGD:12910100
G
Lep
leptin
IMP
DNA:nonsense mutation:cds:
RGD
PMID:23800849
RGD:8549777
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
G
Lepm1Kyo
leptin; ENU induced mutant1, Kyo
IMP
RGD
PMID:23800849
RGD:8549777
G
Pparg
peroxisome proliferator-activated receptor gamma
IAGP
RGD
PMID:27381370
RGD:127285618
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ppargm1Kyo
peroxisome proliferator-activated receptor gamma; ENU induced mutant 1, Kyo
IAGP
RGD
PMID:27381370
RGD:127285618
G
Abcg5
ATP binding cassette subfamily G member 5
IAGP
DNA:missense mutation: p.G583C , 1757G>T (rat)
RGD
PMID:16026620
RGD:1598659
NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
G
Lepr
leptin receptor
IAGP
DNA:mutations:cds: : (rat)
RGD
PMID:30278832 PMID:10901178 PMID:28746409
RGD:401960095 , RGD:401965414 , RGD:401965413
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
G
Gla
galactosidase, alpha
IMP
compared to wild type
RGD
PMID:34541380
RGD:401976419
NCBI chr X:97,769,227...97,780,646
Ensembl chr X:97,768,996...97,780,664
G
Glaem2Mcwi
galactosidase, alpha; CRISPR/Cas9 system induced mutant 2, Medical College of Wisconsin
IMP
compared to wild type
RGD
PMID:34541380
RGD:401976419
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