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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:Hirano bodies
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Accession:MP:0014067 term browser browse the term
Definition:eosinophilic intracytoplasmic inclusions which have a highly characteristic crystalloid fine structure; these inclusions occur predominantly in the neuronal processes of the CA1 area in Ammon's horn but have been noted in other areas of the nervous system; these bodies contain epitopes of actin, actin-associated proteins, tau, middle molecular weight neurofilaments subunit and a C-terminal fragment of beta-amyloid precursor protein; these inclusions have been observed in amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam, Alzheimer's disease, Pick's disease and 'normal' elderly individuals and animal models



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  mammalian phenotype 5368
    nervous system phenotype 360
      abnormal nervous system morphology 208
        nervous system inclusion bodies 10
          Hirano bodies 0
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