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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal intestinal goblet cell physiology
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Accession:MP:0013799 term browser browse the term
Definition:any functional anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the small and large intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus; intestinal goblet cells produce a number of effector molecules including a range of mucins and antimicrobial proteins, such as trefoil factors and resistin-like molecules, which enable these to play a key part in innate defense mechanisms in the gut, against both bacterial and parasitic infections



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  mammalian phenotype 5368
    cellular phenotype 167
      abnormal cell physiology 137
        abnormal intestinal goblet cell physiology 0
Path 2
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  mammalian phenotype 5368
    digestive/alimentary phenotype 75
      abnormal digestive system physiology 28
        abnormal intestine physiology 4
          abnormal intestinal epithelium physiology 0
            abnormal intestinal goblet cell physiology 0
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