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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased T-helper cell number
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Accession:MP:0013763 term browser browse the term
Definition:increase in the number of an effector T cell that provides help in the form of secreted cytokines to other immune cells
Synonyms:exact_synonym: increased helper T lymphocyte number


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increased T-helper cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa5 annexin A5 IAGP MGI PMID:22692895 NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043 		JBrowse link
G Anxa6 annexin A6 IAGP MGI PMID:22692895 NCBI chr11:54,869,779...54,924,297
Ensembl chr11:54,869,934...54,924,271 		JBrowse link
G Card11 caspase recruitment domain family, member 11 IEA MGI NCBI chr 5:140,858,109...140,986,398
Ensembl chr 5:140,858,745...140,986,337 		JBrowse link
G Clock clock circadian regulator IEA MGI NCBI chr 5:76,357,715...76,452,675
Ensembl chr 5:76,357,715...76,452,639 		JBrowse link
G Col10a1 collagen, type X, alpha 1 IAGP MGI PMID:22692895 NCBI chr10:34,265,977...34,273,081
Ensembl chr10:34,265,977...34,273,081 		JBrowse link
G Dcaf15 DDB1 and CUL4 associated factor 15 IEA MGI NCBI chr 8:84,823,698...84,831,426
Ensembl chr 8:84,823,701...84,831,397 		JBrowse link
G Duoxa2 dual oxidase maturation factor 2 IEA MGI NCBI chr 2:122,129,381...122,133,088
Ensembl chr 2:122,129,381...122,133,366 		JBrowse link
G Klhl6 kelch-like 6 IEA MGI NCBI chr16:19,765,242...19,801,766
Ensembl chr16:19,765,246...19,801,787 		JBrowse link
G Mpp1 membrane protein, palmitoylated IEA MGI NCBI chr  X:74,153,339...74,174,622
Ensembl chr  X:74,153,339...74,174,622 		JBrowse link
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase, type II, gamma IAGP MGI PMID:27313209 NCBI chr10:127,032,936...127,047,508
Ensembl chr10:127,032,936...127,047,454 		JBrowse link
G Psmb11 proteasome (prosome, macropain) subunit, beta type, 11 IEA MGI NCBI chr14:54,862,767...54,867,013
Ensembl chr14:54,858,890...54,867,013 		JBrowse link
G Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 IEA MGI NCBI chr 9:55,985,729...56,036,174
Ensembl chr 9:55,997,246...56,036,172 		JBrowse link
increased T follicular helper cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 antigen IAGP MGI PMID:30013024 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Foxp3 forkhead box P3 IAGP MGI PMID:31296356 PMID:38329807 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:38329807 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,055,336 		JBrowse link
G Id3 inhibitor of DNA binding 3 IAGP MGI PMID:21857655 NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066 		JBrowse link
G Ighg1 immunoglobulin heavy constant gamma 1 (G1m marker) IAGP MGI PMID:30013024 NCBI chr12:113,290,161...113,294,143
Ensembl chr12:113,288,860...113,294,143 		JBrowse link
G Ikzf4 IKAROS family zinc finger 4 IAGP MGI PMID:31296356 NCBI chr10:128,466,708...128,505,668
Ensembl chr10:128,466,712...128,505,227 		JBrowse link
G Il1r2 interleukin 1 receptor, type II IAGP MGI PMID:38329807 NCBI chr 1:40,123,872...40,164,390
Ensembl chr 1:40,113,239...40,164,391 		JBrowse link
G Mir146 microRNA 146 IAGP MGI PMID:30013024 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288 		JBrowse link
G Mir146b microRNA 146b IAGP MGI PMID:30013024 NCBI chr19:46,331,201...46,331,309
Ensembl chr19:46,331,201...46,331,309 		JBrowse link
G Pnp purine-nucleoside phosphorylase IEA MGI NCBI chr14:51,181,760...51,190,869
Ensembl chr14:51,168,539...51,190,869 		JBrowse link
G Prdm1 PR domain containing 1, with ZNF domain IAGP MGI PMID:21948081 NCBI chr10:44,313,170...44,404,579
Ensembl chr10:44,313,173...44,404,497 		JBrowse link
G Pten phosphatase and tensin homolog IAGP MGI PMID:20826752 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Rc3h1 RING CCCH (C3H) domains 1 IAGP MGI PMID:22700722 PMID:23583642 PMID:23583643 NCBI chr 1:160,733,981...160,802,546
Ensembl chr 1:160,733,988...160,802,548 		JBrowse link
G Rc3h2 ring finger and CCCH-type zinc finger domains 2 IAGP MGI PMID:23583642 PMID:23583643 NCBI chr 2:37,260,078...37,313,007
Ensembl chr 2:37,260,081...37,312,915 		JBrowse link
G Rhoa ras homolog family member A IAGP MGI PMID:29398449 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
G Rinl Ras and Rab interactor-like IAGP MGI PMID:37703004 NCBI chr 7:28,488,186...28,498,390
Ensembl chr 7:28,488,394...28,498,388 		JBrowse link
G Rnaseh2b ribonuclease H2, subunit B IAGP MGI PMID:35477763 NCBI chr14:62,569,517...62,610,445
Ensembl chr14:62,530,038...62,610,441 		JBrowse link
G Scarf1 scavenger receptor class F, member 1 IAGP MGI PMID:23892722 NCBI chr11:75,404,310...75,417,408
Ensembl chr11:75,404,366...75,417,408 		JBrowse link
G Tlr7 toll-like receptor 7 IAGP MGI PMID:35477763 NCBI chr  X:166,086,376...166,113,570
Ensembl chr  X:166,087,925...166,113,554 		JBrowse link
G Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 IAGP MGI PMID:20826752 NCBI chr 4:156,098,049...156,101,070
Ensembl chr 4:156,098,300...156,101,069 		JBrowse link
G Tnip1 TNFAIP3 interacting protein 1 IAGP MGI PMID:21606507 NCBI chr11:54,801,613...54,853,766
Ensembl chr11:54,801,611...54,853,743 		JBrowse link
increased T-helper 1 cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 a disintegrin and metallopeptidase domain 17 IAGP MGI PMID:25902485 NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633 		JBrowse link
G B2m beta-2 microglobulin IAGP MGI PMID:17562770 NCBI chr 2:121,978,168...121,983,563
Ensembl chr 2:121,978,167...121,983,564 		JBrowse link
G B9d2 B9 protein domain 2 IAGP MGI PMID:21435587 NCBI chr 7:25,380,205...25,385,987
Ensembl chr 7:25,380,205...25,385,983 		JBrowse link
G Dusp14 dual specificity phosphatase 14 IAGP MGI PMID:24403530 NCBI chr11:83,938,859...83,960,016
Ensembl chr11:83,938,867...83,960,087 		JBrowse link
G Egfr epidermal growth factor receptor IAGP MGI PMID:25902485 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Gata3 GATA binding protein 3 IAGP MGI PMID:15475959 NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:23966625 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,055,336 		JBrowse link
G Il9r interleukin 9 receptor IAGP MGI PMID:19433802 NCBI chr11:32,137,544...32,155,283
Ensembl chr11:32,137,541...32,150,279 		JBrowse link
G Itgb2 integrin beta 2 IAGP MGI PMID:14634077 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542 		JBrowse link
G Lgals9 lectin, galactose binding, soluble 9 IAGP MGI PMID:18282810 NCBI chr11:78,853,805...78,875,750
Ensembl chr11:78,853,800...78,875,772 		JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 IAGP MGI PMID:34420035 NCBI chr18:70,701,298...70,761,769
Ensembl chr18:70,701,260...70,759,202 		JBrowse link
G Mir126a microRNA 126a IAGP MGI PMID:34931339 NCBI chr 2:26,481,369...26,481,441
Ensembl chr 2:26,481,369...26,481,441 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 IAGP MGI PMID:19501001 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 IAGP MGI PMID:21468021 NCBI chr 2:56,996,845...57,014,152
Ensembl chr 2:56,996,842...57,014,015 		JBrowse link
G Nup210 nucleoporin 210 IAGP MGI PMID:30323813 NCBI chr 6:90,990,049...91,095,920
Ensembl chr 6:90,990,050...91,093,811 		JBrowse link
G Pdcd1 programmed cell death 1 IAGP MGI PMID:22949674 NCBI chr 1:93,966,027...93,980,278
Ensembl chr 1:93,966,027...93,980,278 		JBrowse link
G Reg3g regenerating islet-derived 3 gamma IAGP MGI PMID:21998396 NCBI chr 6:78,443,252...78,445,857
Ensembl chr 6:78,443,252...78,445,855 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 IAGP MGI PMID:25902485 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
G Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) IAGP MGI PMID:17562770 NCBI chr17:34,406,530...34,416,199
Ensembl chr17:34,406,527...34,416,199 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 IAGP MGI PMID:11342667 PMID:21435587 PMID:23569233 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 IAGP MGI PMID:21435587 NCBI chr 4:156,098,049...156,101,070
Ensembl chr 4:156,098,300...156,101,069 		JBrowse link
G Tnfsf12 tumor necrosis factor (ligand) superfamily, member 12 IAGP MGI PMID:16325585 NCBI chr11:69,577,066...69,586,924
Ensembl chr11:69,577,076...69,586,675 		JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator IAGP MGI PMID:21683627 NCBI chr19:3,985,222...3,999,340
Ensembl chr19:3,985,186...3,999,340 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 IAGP MGI PMID:30662948 NCBI chr  X:95,290,807...95,337,044
Ensembl chr  X:95,290,809...95,337,044 		JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 IAGP MGI PMID:21727190 NCBI chr 3:100,732,775...100,805,555
Ensembl chr 3:100,732,775...100,804,238 		JBrowse link
increased T-helper 17 cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ackr4 atypical chemokine receptor 4 IAGP MGI PMID:20562329 NCBI chr 9:103,974,881...104,003,842
Ensembl chr 9:103,961,356...104,004,132 		JBrowse link
G Adam17 a disintegrin and metallopeptidase domain 17 IAGP MGI PMID:25902485 NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633 		JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 IAGP MGI PMID:23500093 NCBI chr17:93,506,448...93,513,967
Ensembl chr17:93,506,445...93,513,965 		JBrowse link
G Bsg basigin IAGP MGI PMID:25891969 NCBI chr10:79,540,192...79,547,813
Ensembl chr10:79,540,325...79,547,803 		JBrowse link
G Dusp14 dual specificity phosphatase 14 IAGP MGI PMID:24403530 NCBI chr11:83,938,859...83,960,016
Ensembl chr11:83,938,867...83,960,087 		JBrowse link
G Egfr epidermal growth factor receptor IAGP MGI PMID:25902485 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 IAGP MGI PMID:23241884 NCBI chr19:43,678,128...43,722,292
Ensembl chr19:43,678,111...43,722,136 		JBrowse link
G Extl1 exostosin-like glycosyltransferase 1 IAGP MGI PMID:36656709 NCBI chr 4:134,083,684...134,099,893
Ensembl chr 4:134,083,683...134,111,161 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:23966625 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,055,336 		JBrowse link
G Ier3 immediate early response 3 IAGP MGI PMID:22550081 NCBI chr17:36,132,605...36,133,803
Ensembl chr17:36,132,576...36,133,815 		JBrowse link
G Il17ra interleukin 17 receptor A IAGP MGI PMID:22951726 NCBI chr 6:120,440,143...120,460,692
Ensembl chr 6:120,440,208...120,464,520 		JBrowse link
G Mir126a microRNA 126a IAGP MGI PMID:34931339 NCBI chr 2:26,481,369...26,481,441
Ensembl chr 2:26,481,369...26,481,441 		JBrowse link
G Nfil3 nuclear factor, interleukin 3, regulated IAGP MGI PMID:24442434 NCBI chr13:53,121,245...53,136,914
Ensembl chr13:53,121,245...53,135,109 		JBrowse link
G Rag2 recombination activating gene 2 IAGP MGI PMID:17363300 NCBI chr 2:101,455,057...101,462,873
Ensembl chr 2:101,455,063...101,462,874 		JBrowse link
G Siglech sialic acid binding Ig-like lectin H IAGP MGI PMID:22177923 NCBI chr 7:55,417,916...55,429,196
Ensembl chr 7:55,417,926...55,428,673 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 IAGP MGI PMID:25902485 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 IAGP MGI PMID:23633022 NCBI chr12:87,351,832...87,435,129
Ensembl chr12:87,351,832...87,435,129 		JBrowse link
G Tnfaip8 tumor necrosis factor, alpha-induced protein 8 IAGP MGI PMID:37459052 NCBI chr18:50,112,494...50,226,296
Ensembl chr18:50,112,494...50,240,240 		JBrowse link
G Tnfaip8l1 tumor necrosis factor, alpha-induced protein 8-like 1 IAGP MGI PMID:37459052 NCBI chr17:56,469,439...56,491,249
Ensembl chr17:56,469,477...56,480,955 		JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator IAGP MGI PMID:21683627 NCBI chr19:3,985,222...3,999,340
Ensembl chr19:3,985,186...3,999,340 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 IAGP MGI PMID:30662948 NCBI chr  X:95,290,807...95,337,044
Ensembl chr  X:95,290,809...95,337,044 		JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 IAGP MGI PMID:21727190 NCBI chr 3:100,732,775...100,805,555
Ensembl chr 3:100,732,775...100,804,238 		JBrowse link
G Zc3h12d zinc finger CCCH type containing 12D IAGP MGI PMID:24415781 NCBI chr10:7,708,087...7,746,161
Ensembl chr10:7,708,234...7,746,160 		JBrowse link
increased T-helper 2 cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 a disintegrin and metallopeptidase domain 17 IAGP MGI PMID:25902485 NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633 		JBrowse link
G Apoe apolipoprotein E IAGP MGI PMID:9541503 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Egfr epidermal growth factor receptor IAGP MGI PMID:25902485 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Il13ra1 interleukin 13 receptor, alpha 1 IAGP MGI PMID:18066066 NCBI chr  X:35,375,761...35,434,915
Ensembl chr  X:35,375,763...35,434,912 		JBrowse link
G Il17b interleukin 17B IAGP MGI PMID:25888259 NCBI chr18:61,821,006...61,825,609
Ensembl chr18:61,817,958...61,825,609 		JBrowse link
G Irf1 interferon regulatory factor 1 IAGP MGI PMID:9379011 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200 		JBrowse link
G Lat linker for activation of T cells IAGP MGI PMID:12065839 PMID:23793062 NCBI chr 7:125,962,999...125,968,877
Ensembl chr 7:125,962,996...125,968,742 		JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 IAGP MGI PMID:34420035 NCBI chr18:70,701,298...70,761,769
Ensembl chr18:70,701,260...70,759,202 		JBrowse link
G Mir155 microRNA 155 IAGP MGI PMID:17463290 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mmp9 matrix metallopeptidase 9 IAGP MGI PMID:14764732 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 IAGP MGI PMID:22547705 NCBI chr18:38,551,960...38,598,250
Ensembl chr18:38,543,449...38,598,356 		JBrowse link
G Polb polymerase (DNA directed), beta IAGP MGI PMID:24388753 NCBI chr 8:23,118,135...23,143,482
Ensembl chr 8:23,118,142...23,143,451 		JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 IAGP MGI PMID:19107198 NCBI chr 5:103,573,058...103,746,227
Ensembl chr 5:103,573,058...103,746,169 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 IAGP MGI PMID:25902485 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
G Tbx21 T-box 21 IAGP MGI PMID:11786644 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 17088
    hematopoietic system phenotype 5610
      abnormal hematopoietic system morphology/development 5136
        abnormal hematopoietic cell morphology 4313
          abnormal hematopoietic cell number 3121
            abnormal leukocyte cell number 2606
              increased leukocyte cell number 1802
                increased lymphocyte cell number 1017
                  increased T cell number 656
                    increased T-helper cell number 81
                      increased T follicular helper cell number 21
                      increased T-helper 1 cell number 25
                      increased T-helper 17 cell number 23
                      increased T-helper 2 cell number 15
Path 2
Term Annotations click to browse term
  mammalian phenotype 17088
    hematopoietic system phenotype 5610
      abnormal hematopoietic system morphology/development 5136
        abnormal hematopoietic cell morphology 4313
          abnormal leukocyte morphology 2895
            abnormal mononuclear cell morphology 2315
              abnormal lymphocyte morphology 1876
                abnormal T cell morphology 1188
                  abnormal T cell number 1090
                    abnormal effector T cell number 269
                      abnormal T-helper cell number 153
                        increased T-helper cell number 81
                          increased T follicular helper cell number 21
                          increased T-helper 1 cell number 25
                          increased T-helper 17 cell number 23
                          increased T-helper 2 cell number 15
paths to the root