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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal Harderian gland development
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Accession:MP:0013439 term browser browse the term
Definition:aberrant formation or incomplete differentiation of the sebaceous gland located behind the eyeball that excretes fluid that facilitates movement of the nictitating membrane; in rodents, the Harderian gland originates from the nasal part of the conjunctival epithelium at E16 and forms a branched structure behind the eyeball; in contrast to the acinar morphology of the lacrimal gland, the Harderian gland has a tubulo-alveolar organization and is composed exclusively of one type of secretory cell; in primates, the HG is either absent or vestigial
Comment:Note that the Harderian gland is found in all terrestrial vertebrate groups, including amphibia, reptiles, birds, and mammals. However, it appears to be absent in certain mammals such as bats, cows, horses, and higher primates. Though largely absent in the adult human, it is present in the fetal and neonatal stages
Synonyms:exact_synonym: Harderian gland dysgenesis


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  mammalian phenotype 5420
    endocrine/exocrine gland phenotype 394
      abnormal gland morphology 333
        abnormal gland development 7
          abnormal Harderian gland development 0
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  mammalian phenotype 5420
    endocrine/exocrine gland phenotype 394
      abnormal gland morphology 333
        abnormal exocrine gland morphology 119
          abnormal merocrine gland morphology 0
            abnormal Harderian gland morphology 0
              abnormal Harderian gland development 0
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