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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal Meibomian gland development
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Accession:MP:0013385 term browser browse the term
Definition:aberrant formation or incomplete differentiation of the sebaceous glands located at the rim of the eyelids inside the tarsal plate and responsible for the supply of meibum, an oily substance that prevents evaporation of the eye's tear film; in mice, meibomian gland development is initiated around E18.5 with the formation of an epithelial placode and mesenchymal condensation, similar to that observed in hair follicle development; invagination of the epithelium into the developing mesenchyme then continues from birth to about P3 with initial branching of the epithelial cord detected at P5; by P8 the developing meibomian gland shows extensive ductal branching and the formation of distinct acini with mature meibomian glands present by P15 or eyelid opening
Synonyms:exact_synonym: abnormal tarsal gland development


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Term Annotations click to browse term
  mammalian phenotype 5420
    endocrine/exocrine gland phenotype 394
      abnormal gland morphology 333
        abnormal gland development 7
          abnormal Meibomian gland development 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5420
    endocrine/exocrine gland phenotype 394
      abnormal gland morphology 333
        abnormal exocrine gland morphology 119
          abnormal holocrine gland morphology 6
            abnormal sebaceous gland morphology 6
              abnormal skin sebaceous gland morphology 3
                abnormal Meibomian gland morphology 3
                  abnormal Meibomian gland development 0
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