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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number
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Accession:MP:0012773 term browser browse the term
Definition:any anomaly in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release


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decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S BBDP.ACI-(D2Arb16-D2Rat63)/Sunn IAGP compared to BBDP/WorSunn RGD PMID:24920533 RGD:10043114 NCBI chr 2:190,602,746...222,436,696 JBrowse link
S BBDP.ACI-(D2Mit8-D2Rat354)/Sunn IAGP compared to BBDP/WorSunn RGD PMID:24920533 RGD:10043114 NCBI chr 2:143,657,411...191,987,650 JBrowse link
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S BBDP.ACI-(D2Mit8-D2Arb16)(D2Rat354-D2Rat69)/Sunn IAGP compared to BBDP/WorSunn RGD PMID:24920533 RGD:10043114 NCBI chr 2:143,657,411...190,602,963
NCBI chr 2:191,987,426...191,987,650 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5420
    immune system phenotype 519
      abnormal immune system morphology 211
        abnormal immune system cell morphology 150
          abnormal leukocyte morphology 150
            abnormal leukocyte cell number 136
              abnormal lymphocyte cell number 93
                abnormal T cell number 63
                  abnormal regulatory T cell number 7
                    abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number 3
                      abnormal KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 0
                      abnormal memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 0
                      decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 2
                      increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 1
Path 2
Term Annotations click to browse term
  mammalian phenotype 5420
    immune system phenotype 519
      abnormal immune system morphology 211
        abnormal immune system cell morphology 150
          abnormal leukocyte morphology 150
            abnormal mononuclear cell morphology 125
              abnormal lymphocyte morphology 97
                abnormal T cell morphology 67
                  abnormal effector T cell morphology 21
                    abnormal CD4-positive, alpha beta T cell morphology 15
                      abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology 3
                        abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number 3
                          abnormal KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 0
                          abnormal memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 0
                          decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 2
                          increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 1
paths to the root