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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number
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Accession:MP:0012773 term browser browse the term
Definition:any anomaly in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release


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abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Colgalt2 collagen beta(1-O)galactosyltransferase 2 IAGP MGI PMID:30355948 NCBI chr 1:152,275,485...152,386,942
Ensembl chr 1:152,275,581...152,386,446 		JBrowse link
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper transcription factor, ATF-like IAGP MGI PMID:20421391 NCBI chr12:85,733,494...85,755,861
Ensembl chr12:85,733,443...85,755,861 		JBrowse link
G Card11 caspase recruitment domain family, member 11 IEA MGI NCBI chr 5:140,858,109...140,986,398
Ensembl chr 5:140,858,745...140,986,337 		JBrowse link
G Cd27 CD27 antigen IEA MGI NCBI chr 6:125,209,583...125,214,014
Ensembl chr 6:125,209,585...125,213,973 		JBrowse link
G Cd38 CD38 antigen IEA MGI NCBI chr 5:44,026,153...44,069,714
Ensembl chr 5:44,025,895...44,069,717 		JBrowse link
G Diaph1 diaphanous related formin 1 IEA MGI NCBI chr18:37,976,654...38,068,573
Ensembl chr18:37,976,654...38,068,529 		JBrowse link
G Elmo1 engulfment and cell motility 1 IEA MGI NCBI chr13:20,274,677...20,792,523
Ensembl chr13:20,274,766...20,792,523 		JBrowse link
G Foxp3 forkhead box P3 IAGP MGI PMID:12612578 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Gm5148 predicted gene 5148 IEA MGI NCBI chr 3:37,768,339...37,778,509
Ensembl chr 3:37,768,339...37,778,639 		JBrowse link
G Gmds GDP-mannose 4, 6-dehydratase IEA MGI NCBI chr13:32,003,566...32,522,744
Ensembl chr13:32,003,562...32,522,723 		JBrowse link
G Gmnn geminin IAGP MGI PMID:20107189 NCBI chr13:24,935,828...24,954,222
Ensembl chr13:24,935,828...24,945,906 		JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 IAGP MGI PMID:16709807 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta IAGP MGI PMID:33658989 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Ikzf1 IKAROS family zinc finger 1 IEA MGI NCBI chr11:11,634,970...11,722,930
Ensembl chr11:11,634,980...11,722,926 		JBrowse link
G Itk IL2 inducible T cell kinase IEA MGI NCBI chr11:46,215,975...46,280,342
Ensembl chr11:46,215,977...46,280,342 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 IAGP MGI PMID:26132627 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A IAGP MGI PMID:19679885 NCBI chr  X:163,202,814...163,216,912
Ensembl chr  X:163,202,783...163,216,912 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 IEA MGI NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 IEA MGI NCBI chr 2:117,110,464...117,173,358
Ensembl chr 2:117,110,474...117,173,482 		JBrowse link
G St14 suppression of tumorigenicity 14 (colon carcinoma) IAGP MGI PMID:24551030 NCBI chr 9:30,999,886...31,043,138
Ensembl chr 9:31,000,698...31,043,149 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A IAGP MGI PMID:16493008 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B IAGP MGI PMID:16493008 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550 		JBrowse link
G Themis thymocyte selection associated IEA MGI NCBI chr10:28,544,356...28,759,816
Ensembl chr10:28,544,356...28,759,814 		JBrowse link
G Zap70 zeta-chain (TCR) associated protein kinase IEA MGI NCBI chr 1:36,800,912...36,821,899
Ensembl chr 1:36,800,879...36,821,899 		JBrowse link
decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa2 dual oxidase maturation factor 2 IEA MGI NCBI chr 2:122,129,381...122,133,088
Ensembl chr 2:122,129,381...122,133,366 		JBrowse link
G Gmds GDP-mannose 4, 6-dehydratase IEA MGI NCBI chr13:32,003,566...32,522,744
Ensembl chr13:32,003,562...32,522,723 		JBrowse link
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc1b actin related protein 2/3 complex, subunit 1B IEA MGI NCBI chr 5:145,051,066...145,064,996
Ensembl chr 5:145,051,025...145,067,515 		JBrowse link
G C9orf72 C9orf72, member of C9orf72-SMCR8 complex IAGP MGI PMID:27412785 NCBI chr 4:35,191,285...35,226,153
Ensembl chr 4:35,191,285...35,226,175 		JBrowse link
G Cd22 CD22 antigen IEA MGI NCBI chr 7:30,564,829...30,579,767
Ensembl chr 7:30,564,827...30,579,767 		JBrowse link
G Cog6 component of oligomeric golgi complex 6 IEA MGI NCBI chr 3:52,889,544...52,924,644
Ensembl chr 3:52,889,296...52,924,658 		JBrowse link
G Dcaf15 DDB1 and CUL4 associated factor 15 IEA MGI NCBI chr 8:84,823,698...84,831,426
Ensembl chr 8:84,823,701...84,831,397 		JBrowse link
G Diaph1 diaphanous related formin 1 IEA MGI NCBI chr18:37,976,654...38,068,573
Ensembl chr18:37,976,654...38,068,529 		JBrowse link
G Dph6 diphthamine biosynthesis 6 IEA MGI NCBI chr 2:114,346,897...114,485,518
Ensembl chr 2:114,346,897...114,485,445 		JBrowse link
G Duoxa2 dual oxidase maturation factor 2 IEA MGI NCBI chr 2:122,129,381...122,133,088
Ensembl chr 2:122,129,381...122,133,366 		JBrowse link
G Fam83h family with sequence similarity 83, member H IEA MGI NCBI chr15:75,872,941...75,886,185
Ensembl chr15:75,872,942...75,886,185 		JBrowse link
G Foxn4 forkhead box N4 IEA MGI NCBI chr 5:114,392,225...114,412,486
Ensembl chr 5:114,392,225...114,411,868 		JBrowse link
G Hbs1l Hbs1-like (S. cerevisiae) IEA MGI NCBI chr10:21,171,876...21,244,788
Ensembl chr10:21,171,878...21,244,797 		JBrowse link
G Krt1 keratin 1 IEA MGI NCBI chr15:101,753,861...101,759,221
Ensembl chr15:101,753,861...101,759,229 		JBrowse link
G Lair1 leukocyte-associated Ig-like receptor 1 IAGP MGI PMID:22156345 NCBI chr 7:4,010,072...4,076,566
Ensembl chr 7:4,006,401...4,066,178 		JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 IEA MGI NCBI chr16:87,173,539...87,229,504
Ensembl chr16:87,173,539...87,229,500 		JBrowse link
G Mmp20 matrix metallopeptidase 20 (enamelysin) IEA MGI NCBI chr 9:7,628,232...7,674,969
Ensembl chr 9:7,628,232...7,674,980 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 IAGP MGI PMID:28471497 NCBI chr 1:152,675,904...152,712,743
Ensembl chr 1:152,675,945...152,712,742 		JBrowse link
G Nup210 nucleoporin 210 IAGP MGI PMID:30323813 NCBI chr 6:90,990,049...91,095,920
Ensembl chr 6:90,990,050...91,093,811 		JBrowse link
G Pax5 paired box 5 IEA MGI NCBI chr 4:44,524,748...44,710,694
Ensembl chr 4:44,524,757...44,710,487 		JBrowse link
G Phf6 PHD finger protein 6 IAGP MGI PMID:31395598 NCBI chr  X:52,001,091...52,045,838
Ensembl chr  X:52,001,143...52,045,820 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA MGI NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725 		JBrowse link
G Siglecg sialic acid binding Ig-like lectin G IEA MGI NCBI chr 7:43,057,623...43,067,773
Ensembl chr 7:43,057,628...43,067,782 		JBrowse link
G Sik3 SIK family kinase 3 IEA MGI NCBI chr 9:45,924,099...46,135,492
Ensembl chr 9:45,924,118...46,135,492 		JBrowse link
G Spred1 sprouty protein with EVH-1 domain 1, related sequence IEA MGI NCBI chr 2:116,951,576...117,012,760
Ensembl chr 2:116,951,855...117,012,760 		JBrowse link
G St14 suppression of tumorigenicity 14 (colon carcinoma) IAGP MGI PMID:24551030 NCBI chr 9:30,999,886...31,043,138
Ensembl chr 9:31,000,698...31,043,149 		JBrowse link
G Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) IEA MGI NCBI chr17:34,406,530...34,416,199
Ensembl chr17:34,406,527...34,416,199 		JBrowse link
G Themis thymocyte selection associated IEA MGI NCBI chr10:28,544,356...28,759,816
Ensembl chr10:28,544,356...28,759,814 		JBrowse link
G Zap70 zeta-chain (TCR) associated protein kinase IEA MGI NCBI chr 1:36,800,912...36,821,899
Ensembl chr 1:36,800,879...36,821,899 		JBrowse link
G Zscan10 zinc finger and SCAN domain containing 10 IAGP MGI PMID:25111779 NCBI chr17:23,819,800...23,829,993
Ensembl chr17:23,819,830...23,829,993 		JBrowse link
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef1 Rho guanine nucleotide exchange factor 1 IEA MGI NCBI chr 7:24,601,762...24,626,019
Ensembl chr 7:24,602,337...24,626,019 		JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B IEA MGI NCBI chr 5:145,051,066...145,064,996
Ensembl chr 5:145,051,025...145,067,515 		JBrowse link
G Bach2 BTB and CNC homology, basic leucine zipper transcription factor 2 IEA MGI NCBI chr 4:32,238,413...32,586,109
Ensembl chr 4:32,238,804...32,586,108 		JBrowse link
G Cog6 component of oligomeric golgi complex 6 IEA MGI NCBI chr 3:52,889,544...52,924,644
Ensembl chr 3:52,889,296...52,924,658 		JBrowse link
G Dph6 diphthamine biosynthesis 6 IEA MGI NCBI chr 2:114,346,897...114,485,518
Ensembl chr 2:114,346,897...114,485,445 		JBrowse link
G Il27 interleukin 27 IEA MGI NCBI chr 7:126,188,181...126,194,197
Ensembl chr 7:126,188,182...126,194,113 		JBrowse link
G Sik3 SIK family kinase 3 IEA MGI NCBI chr 9:45,924,099...46,135,492
Ensembl chr 9:45,924,118...46,135,492 		JBrowse link
increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc1b actin related protein 2/3 complex, subunit 1B IEA MGI NCBI chr 5:145,051,066...145,064,996
Ensembl chr 5:145,051,025...145,067,515 		JBrowse link
G Bach2 BTB and CNC homology, basic leucine zipper transcription factor 2 IEA MGI NCBI chr 4:32,238,413...32,586,109
Ensembl chr 4:32,238,804...32,586,108 		JBrowse link
G Cog6 component of oligomeric golgi complex 6 IEA MGI NCBI chr 3:52,889,544...52,924,644
Ensembl chr 3:52,889,296...52,924,658 		JBrowse link
G Cttnbp2 cortactin binding protein 2 IEA MGI NCBI chr 6:18,366,470...18,515,216
Ensembl chr 6:18,366,477...18,514,842 		JBrowse link
G Dph6 diphthamine biosynthesis 6 IEA MGI NCBI chr 2:114,346,897...114,485,518
Ensembl chr 2:114,346,897...114,485,445 		JBrowse link
G Gmds GDP-mannose 4, 6-dehydratase IEA MGI NCBI chr13:32,003,566...32,522,744
Ensembl chr13:32,003,562...32,522,723 		JBrowse link
G Hbs1l Hbs1-like (S. cerevisiae) IEA MGI NCBI chr10:21,171,876...21,244,788
Ensembl chr10:21,171,878...21,244,797 		JBrowse link
G Pclaf PCNA clamp associated factor IEA MGI NCBI chr 9:65,797,605...65,810,833
Ensembl chr 9:65,797,519...65,810,548 		JBrowse link
G Pepd peptidase D IEA MGI NCBI chr 7:34,611,832...34,744,131
Ensembl chr 7:34,611,804...34,744,133 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 17065
    immune system phenotype 5763
      abnormal immune system morphology 4136
        abnormal immune system cell morphology 2907
          abnormal leukocyte morphology 2888
            abnormal leukocyte cell number 2601
              abnormal lymphocyte cell number 1733
                abnormal T cell number 1087
                  abnormal regulatory T cell number 167
                    abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number 54
                      abnormal KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 7
                      abnormal memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 10
                      decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 24
                      increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 35
Path 2
Term Annotations click to browse term
  mammalian phenotype 17065
    immune system phenotype 5763
      abnormal immune system morphology 4136
        abnormal immune system cell morphology 2907
          abnormal leukocyte morphology 2888
            abnormal mononuclear cell morphology 2308
              abnormal lymphocyte morphology 1871
                abnormal T cell morphology 1185
                  abnormal effector T cell morphology 868
                    abnormal CD4-positive, alpha beta T cell morphology 611
                      abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology 58
                        abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number 54
                          abnormal KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 7
                          abnormal memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 10
                          decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 24
                          increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 35
paths to the root