abnormal neural crest cell delamination - Ontology Report - Rat Genome Database

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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:	abnormal neural crest cell delamination	go back to main search page
Accession:	MP:0012746	browse the term
Definition:	any anomaly in the process by which a neural crest cell (NCC) physically dissociates from the neuroepithelium in the dorsal aspect of the neural tube; premigratory NCCs exist within a fully polarized epithelial layer, adjoined by adherens junctions and tight junctions; NCC delamination involves an epithelial-mesenchymal transition (EMT) during which epithelial cells are converted into migratory mesenchymal cells; EMT requires loss of apical-basal cell polarity and dissolution of tight junctions and is accompanied by changes in cytoskeletal organization and a switch in adhesive properties so that cells can separate from the neuroepithelium and emigrate
Synonyms:	exact_synonym:	abnormal NCC delamination; abnormal NCC emigration; abnormal NCC individualization; abnormal NCC segregation; abnormal neural crest cell emigration; abnormal neural crest cell individualization; abnormal neural crest cell segregation

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Term	Annotations
mammalian phenotype	5373
embryo phenotype	6
abnormal embryonic tissue physiology	0
abnormal neural crest cell physiology	0
abnormal neural crest cell delamination	0

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