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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories ( For more information about these ontologies, see the MGI Publications Page at

Term:abnormal neural crest cell delamination
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Accession:MP:0012746 term browser browse the term
Definition:any anomaly in the process by which a neural crest cell (NCC) physically dissociates from the neuroepithelium in the dorsal aspect of the neural tube; premigratory NCCs exist within a fully polarized epithelial layer, adjoined by adherens junctions and tight junctions; NCC delamination involves an epithelial-mesenchymal transition (EMT) during which epithelial cells are converted into migratory mesenchymal cells; EMT requires loss of apical-basal cell polarity and dissolution of tight junctions and is accompanied by changes in cytoskeletal organization and a switch in adhesive properties so that cells can separate from the neuroepithelium and emigrate
Synonyms:exact_synonym: abnormal NCC delamination;   abnormal NCC emigration;   abnormal NCC individualization;   abnormal NCC segregation;   abnormal neural crest cell emigration;   abnormal neural crest cell individualization;   abnormal neural crest cell segregation

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  mammalian phenotype 5373
    embryo phenotype 6
      abnormal embryonic tissue physiology 0
        abnormal neural crest cell physiology 0
          abnormal neural crest cell delamination 0
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