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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:high preference for an addictive substance
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Accession:MP:0012342 term browser browse the term
Definition:enhanced behavioral response induced by a foreign compound, such as high consumption preference, high induced hyperactivity or stereotypic behavior


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high preference for an addictive substance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor ameliorates IMP WT compared to heterozygous rats RGD PMID:23583595 RGD:38501054 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bdnfem1Sage brain-derived neurotrophic factor; ZFN induced mutant 1, Sage ameliorates IMP WT compared to heterozygous rats RGD PMID:23583595 RGD:38501054
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit IMP compared to wild type RGD PMID:31288250 RGD:150530288 NCBI chr 8:64,265,879...64,294,233
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Chrna5em20(D398N)Pas cholinergic receptor, nicotinic, alpha 5 (neuronal); ZFN induced mutant 20,Pas IMP compared to wild type RGD PMID:31288250 RGD:150530288
G Grm2 glutamate metabotropic receptor 2 IMP knock-out compared to wild-type rats RGD PMID:30283001 RGD:38501063 NCBI chr 8:116,158,810...116,171,857
Ensembl chr 8:107,280,099...107,293,146 		JBrowse link
G Grm2em1 glutamate metabotropic receptor 2; endonuclease induced mutant 1 IMP KO compared to wild-type rats RGD PMID:30283001 RGD:38501063
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  mammalian phenotype 5428
    behavior/neurological phenotype 618
      abnormal behavior 617
        abnormal behavioral response to xenobiotic 141
          preference for addictive substance 81
            high preference for an addictive substance 9
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