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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories ( For more information about these ontologies, see the MGI Publications Page at

Term:abnormal glomerular filtration barrier function
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Accession:MP:0011856 term browser browse the term
Definition:anomaly in the function of the highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules; its integrity is maintained by physicochemical and signalling interplay among its three core constituents -- the fenestrated endothelium of the glomerular capillaries, the glomerular basement membrane, and the filtration slits of the visceral epithelial cell (podocyte); the barrier permits the passage of water, ions, and small molecules from the bloodstream into the Bowman's space and prevents the loss of large and/or negatively charged proteins (e.g. serum albumin) from blood into urine
Synonyms:exact_synonym: abnormal GFB permeability

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abnormal glomerular filtration barrier function term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S CD Cohen diabetic rat IAGP compared to normal diet CD RGD PMID:2134214 RGD:18937003
S FHH.BN(D14Rat98-D14Hmgc4)/Mcwi ameliorates IAGP compared to FHH
compared to BN
RGD PMID:25273069 PMID:25273069 RGD:9685539, RGD:9685539 NCBI chr14:13,015,311...19,848,266 JBrowse link
S FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi IAGP compared to BN RGD PMID:15758045 RGD:1357409 NCBI chr 1:140,879,679...142,314,355 JBrowse link
S FHH/EurMcwi IAGP compared to BN RGD PMID:15758045 RGD:1357409

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  mammalian phenotype 5330
    renal/urinary system phenotype 617
      abnormal renal/urinary system physiology 454
        abnormal kidney physiology 122
          abnormal renal filtration 41
            abnormal renal glomerular filtration 21
              abnormal glomerular filtration barrier function 4
paths to the root