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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories ( For more information about these ontologies, see the MGI Publications Page at

Term:abnormal glomerular filtration barrier function
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Accession:MP:0011856 term browser browse the term
Definition:anomaly in the function of the highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules; its integrity is maintained by physicochemical and signalling interplay among its three core constituents -- the fenestrated endothelium of the glomerular capillaries, the glomerular basement membrane, and the filtration slits of the visceral epithelial cell (podocyte); the barrier permits the passage of water, ions, and small molecules from the bloodstream into the Bowman's space and prevents the loss of large and/or negatively charged proteins (e.g. serum albumin) from blood into urine
Synonyms:exact_synonym: abnormal GFB permeability

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  mammalian phenotype 8
    renal/urinary system phenotype 0
      abnormal renal/urinary system physiology 0
        abnormal kidney physiology 0
          abnormal renal filtration 0
            abnormal renal glomerular filtration 0
              abnormal glomerular filtration barrier function 0
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