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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal CD8-positive, alpha-beta memory T cell proliferation
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Accession:MP:0011821 term browser browse the term
Definition:anomaly in the ability of the CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high, to undergo expansion by cell division


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decreased CD8-positive, alpha-beta memory T cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec1a C-type lectin domain family 1, member a IAGP MGI PMID:35135958 NCBI chr 6:129,403,647...129,428,963
Ensembl chr 6:129,401,735...129,428,963 		JBrowse link
increased CD8-positive, alpha-beta memory T cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd8a CD8 subunit alpha IEA MGI NCBI chr 6:71,350,411...71,356,155
Ensembl chr 6:71,350,411...71,356,157 		JBrowse link
G Itk IL2 inducible T cell kinase IEA MGI NCBI chr11:46,215,975...46,280,342
Ensembl chr11:46,215,977...46,280,342 		JBrowse link
G Ppp3cb protein phosphatase 3, catalytic subunit, beta isoform IEA MGI NCBI chr14:20,549,432...20,596,641
Ensembl chr14:20,549,432...20,596,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16734
    cellular phenotype 5391
      abnormal cell physiology 4790
        abnormal cell proliferation 1647
          abnormal CD8-positive, alpha-beta memory T cell proliferation 4
            decreased CD8-positive, alpha-beta memory T cell proliferation 1
            increased CD8-positive, alpha-beta memory T cell proliferation 3
Path 2
Term Annotations click to browse term
  mammalian phenotype 16734
    immune system phenotype 5613
      abnormal immune system physiology 3422
        abnormal adaptive immunity 1832
          abnormal leukocyte physiology 1753
            abnormal lymphocyte physiology 1291
              abnormal T cell physiology 765
                abnormal memory T cell physiology 20
                  abnormal CD8-positive, alpha-beta memory T cell proliferation 4
                    decreased CD8-positive, alpha-beta memory T cell proliferation 1
                    increased CD8-positive, alpha-beta memory T cell proliferation 3
paths to the root