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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal tricarboxylic acid cycle
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Accession:MP:0010958 term browser browse the term
Definition:any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle
Comment:In eukaryotes the tricarboxylic acid is confined to the mitochondria.
Synonyms:exact_synonym: abnormal Krebs cycle;   abnormal TCA cycle;   abnormal citric acid cycle
 xref: GO:0006099

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  mammalian phenotype 5035
    cellular phenotype 88
      abnormal cell physiology 71
        abnormal mitochondrial physiology 4
          abnormal tricarboxylic acid cycle 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5035
    cellular phenotype 88
      abnormal cell physiology 71
        abnormal cellular respiration 2
          abnormal aerobic respiration 0
            abnormal tricarboxylic acid cycle 0
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