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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal solitary pulmonary neuroendocrine cell morphology
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Accession:MP:0010914 term browser browse the term
Definition:any structural anomaly of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis
Synonyms:exact_synonym: abnormal Feyrter cell morphology;   abnormal Kulschitzky cells;   abnormal Kultschitzky cell of bronchiole;   abnormal PNECs;   abnormal bronchiolar Kulchitsky cell;   abnormal respiratory enterochromaffin cell;   abnormal single pulmonary neuroendocrine cell morphology
 broad_synonym: abnormal P cell
 xref: CL:0002066;   FMA:14118


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Path 1
Term Annotations click to browse term
  mammalian phenotype 5420
    nervous system phenotype 376
      abnormal nervous system morphology 214
        abnormal neuron morphology 70
          abnormal neuroendocrine cell morphology 0
            abnormal solitary pulmonary neuroendocrine cell morphology 0
              decreased solitary pulmonary neuroendocrine cell number + 0
              increased solitary pulmonary neuroendocrine cell number 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5420
    endocrine/exocrine gland phenotype 394
      abnormal gland morphology 333
        abnormal endocrine gland morphology 164
          abnormal neuroendocrine gland morphology 42
            abnormal neuroendocrine cell morphology 0
              abnormal solitary pulmonary neuroendocrine cell morphology 0
                decreased solitary pulmonary neuroendocrine cell number + 0
                increased solitary pulmonary neuroendocrine cell number 0
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