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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal T follicular helper cell differentiation
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Accession:MP:0010188 term browser browse the term
Definition:atypical production of or inability to produce the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production
Synonyms:xref: CL:0002038


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Term Annotations click to browse term
  mammalian phenotype 5418
    immune system phenotype 502
      abnormal immune system morphology 194
        abnormal immune system cell morphology 154
          abnormal leukopoiesis 18
            abnormal lymphopoiesis 18
              abnormal T cell differentiation 18
                abnormal CD4-positive T cell differentiation 4
                  abnormal T follicular helper cell differentiation 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5418
    hematopoietic system phenotype 250
      abnormal hematopoietic system morphology/development 230
        abnormal hematopoietic cell morphology 186
          abnormal leukocyte morphology 154
            abnormal mononuclear cell morphology 127
              abnormal lymphocyte morphology 99
                abnormal T cell morphology 69
                  abnormal effector T cell morphology 23
                    abnormal T-helper cell morphology 1
                      abnormal CD4-positive helper T cell morphology 1
                        abnormal T follicular helper cell morphology 0
                          abnormal T follicular helper cell differentiation 0
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