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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal mammary gland epithelium physiology
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Accession:MP:0010172 term browser browse the term
Definition:any functional anomaly of the mammary gland epithelium which is normally enveloped by a basement membrane, embedded into fatty connective tissue stroma, and organized as a bilayer, with an inner luminal layer of secretory epithelial cells, and an outer basal layer; each cell layer expresses specific molecular markers; luminal epithelial cells are characterized by the expression of the receptors for systemic hormones, i.e. estrogens, progesterone and prolactin, whereas basal cells (aka myoepithelial cells) express smooth muscle contractile proteins; in functionally differentiated mammary gland, during lactation, luminal cells produce milk, whereas myoepithelial cells are contractile and serve for milk expulsion

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Path 1
Term Annotations click to browse term
  mammalian phenotype 0
    integument phenotype 0
      abnormal skin adnexa physiology 0
        abnormal mammary gland physiology 0
          abnormal mammary gland epithelium physiology 0
            abnormal mammary gland myoepithelium physiology + 0
            decreased mammary gland epithelial cell proliferation 0
            increased mammary gland epithelial cell proliferation 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 0
    endocrine/exocrine gland phenotype 0
      abnormal gland physiology 0
        abnormal exocrine gland physiology 0
          abnormal apocrine gland physiology 0
            abnormal mammary gland physiology 0
              abnormal mammary gland epithelium physiology 0
                abnormal mammary gland myoepithelium physiology + 0
                decreased mammary gland epithelial cell proliferation 0
                increased mammary gland epithelial cell proliferation 0
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