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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:decreased DN4 thymocyte number
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Accession:MP:0010136 term browser browse the term
Definition:reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive.
Comment:Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain.
Synonyms:exact_synonym: decreased DN4 alpha-beta immature T lymphocyte number;   decreased DN4 cell number;   decreased DN4 immature T cell number;   reduced DN4 alpha-beta immature T lymphocyte number;   reduced DN4 cell number;   reduced DN4 immature T cell number;   reduced DN4 thymocyte number
 xref: CL:0000808


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decreased DN4 thymocyte number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk6 cyclin dependent kinase 6 IAGP MGI PMID:21508411 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008 		JBrowse link
G Dclre1c DNA cross-link repair 1C IAGP MGI PMID:24069355 NCBI chr 2:3,425,112...3,475,248
Ensembl chr 2:3,425,168...3,465,167 		JBrowse link
G Efnb1 ephrin B1 IAGP MGI PMID:21976681 NCBI chr  X:98,179,667...98,192,628
Ensembl chr  X:98,179,736...98,192,597 		JBrowse link
G Efnb2 ephrin B2 IAGP MGI PMID:21976681 NCBI chr 8:8,667,235...8,711,242
Ensembl chr 8:8,667,434...8,711,242 		JBrowse link
G Gmnn geminin IAGP MGI PMID:20107189 NCBI chr13:24,935,828...24,954,222
Ensembl chr13:24,935,828...24,945,906 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 IAGP MGI PMID:21093323 NCBI chr16:29,883,259...29,886,614
Ensembl chr16:29,883,202...29,886,614 		JBrowse link
G Lrrc8a leucine rich repeat containing 8A VRAC subunit A IAGP MGI PMID:24752297 NCBI chr 2:30,127,781...30,153,802
Ensembl chr 2:30,127,727...30,153,802 		JBrowse link
G Nkap NFKB activating protein IAGP MGI PMID:19409814 NCBI chr  X:36,390,416...36,414,399
Ensembl chr  X:36,390,448...36,414,399 		JBrowse link
G Nmt1 N-myristoyltransferase 1 IAGP MGI PMID:26423150 NCBI chr11:102,919,163...102,959,734
Ensembl chr11:102,919,016...102,959,738 		JBrowse link
G Nmt2 N-myristoyltransferase 2 IAGP MGI PMID:26423150 NCBI chr 2:3,285,249...3,329,914
Ensembl chr 2:3,285,249...3,329,914 		JBrowse link
G Noc2l NOC2 like nucleolar associated transcriptional repressor IAGP MGI PMID:25201955 NCBI chr 4:156,319,112...156,332,078
Ensembl chr 4:156,320,376...156,332,073 		JBrowse link
G Pole3 polymerase (DNA directed), epsilon 3 (p17 subunit) IAGP MGI PMID:32553171 NCBI chr 4:62,440,889...62,443,305
Ensembl chr 4:62,440,886...62,443,305 		JBrowse link
G Prkch protein kinase C, eta IAGP MGI PMID:22155788 NCBI chr12:73,631,570...73,824,959
Ensembl chr12:73,631,570...73,824,959 		JBrowse link
G Prkcq protein kinase C, theta IAGP MGI PMID:22155788 NCBI chr 2:11,176,922...11,306,033
Ensembl chr 2:11,176,919...11,306,033 		JBrowse link
G Prnp prion protein IAGP MGI PMID:16517717 NCBI chr 2:131,751,848...131,780,356
Ensembl chr 2:131,751,848...131,780,349 		JBrowse link
G Ptcra pre T cell antigen receptor alpha IAGP MGI PMID:17555992 PMID:23509324 NCBI chr17:47,066,589...47,074,659
Ensembl chr17:47,066,589...47,074,638 		JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C IAGP MGI PMID:24068938 NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446 		JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 IAGP MGI PMID:22815285 NCBI chr15:6,737,827...6,829,882
Ensembl chr15:6,737,860...6,829,882 		JBrowse link
G Septin9 septin 9 IAGP MGI PMID:23644740 NCBI chr11:117,090,487...117,253,151
Ensembl chr11:117,090,487...117,253,151 		JBrowse link
G Snrnp40 small nuclear ribonucleoprotein 40 (U5) IAGP MGI PMID:31427773 NCBI chr 4:130,253,925...130,283,826
Ensembl chr 4:130,253,925...130,283,819 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IAGP MGI PMID:21746917 NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882 		JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 IAGP MGI PMID:22201126 NCBI chr12:76,416,825...76,443,729
Ensembl chr12:76,417,040...76,443,724 		JBrowse link
G Zfp131 zinc finger protein 131 IAGP MGI PMID:26136427 NCBI chr13:120,226,722...120,253,070
Ensembl chr13:120,226,723...120,252,425 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16963
    hematopoietic system phenotype 5543
      abnormal hematopoietic system morphology/development 5069
        abnormal thymus morphology 860
          decreased thymocyte number 200
            decreased DN4 thymocyte number 23
Path 2
Term Annotations click to browse term
  mammalian phenotype 16963
    hematopoietic system phenotype 5543
      abnormal hematopoietic system morphology/development 5069
        abnormal hematopoietic cell morphology 4235
          abnormal blood cell morphology 3179
            abnormal hemopoiesis 1157
              abnormal definitive hematopoiesis 1130
                abnormal leukopoiesis 870
                  abnormal lymphopoiesis 747
                    abnormal T cell differentiation 489
                      abnormal double-negative T cell morphology 200
                        decreased double-negative T cell number 92
                          decreased DN4 thymocyte number 23
paths to the root