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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:increased gastrointestinal stromal tumor incidence
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Accession:MP:0009515 term browser browse the term
Definition:higher than normal incidence of non-epithelial, mesenchymal tumors of the gastrointestinal tract, thought to originate from the interstitial cells of Cajal, the pacemaker cells that regulate peristalsis in the digestive tract; approximately 70% of GISTs develop in the stomach, 20% in the small intestine, and less than 10% in the esophagus, colon, and rectum; GISTs are tumors of connective tissue, i.e. sarcomas, account for 1-3% of all gastrointestinal malignancies in human, and are typically more cellular than other gastrointestinal sarcomas
Synonyms:exact_synonym: increased gastrointestinal stromal tumour incidence
 related_synonym: GISTs;   gastrointestinal stromal tumor;   gastrointestinal stromal tumour



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Term Annotations click to browse term
  mammalian phenotype 5402
    digestive/alimentary phenotype 78
      abnormal digestive system morphology 58
        increased alimentary system tumor incidence 28
          increased gastrointestinal tumor incidence 17
            increased gastrointestinal stromal tumor incidence 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5402
    neoplasm 244
      abnormal tumor susceptibility 236
        abnormal tumor incidence 225
          increased tumor incidence 166
            increased organ/body region tumor incidence 139
              increased alimentary system tumor incidence 28
                increased gastrointestinal tumor incidence 17
                  increased gastrointestinal stromal tumor incidence 0
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