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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:decreased interleukin-4 secretion
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Accession:MP:0008700 term browser browse the term
Definition:reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells
Synonyms:exact_synonym: decreased B-cell growth factor-1 secretion;   decreased B-cell growth factor-I secretion;   decreased B-cell proliferating factor secretion;   decreased B-cell stimulating factor-1 secretion;   decreased B-cell stimulatory factor 1 secretion;   decreased BCGF-1 secretion;   decreased BSF-1 secretion;   decreased Binetrakin secretion;   decreased IL-4 secretion;   decreased IL4 secretion;   decreased MCGF-2 secretion;   decreased mast cell growth factor-2 secretion;   reduced B cell stimulatory factor-1 secretion;   reduced B-cell growth factor-1 secretion;   reduced B-cell growth factor-I secretion;   reduced B-cell proliferating factor secretion;   reduced B-cell stimulating factor-1 secretion;   reduced BCGF-1 secretion;   reduced BSF-1 secretion;   reduced Binetrakin secretion;   reduced IL-4 secretion;   reduced IL4 secretion;   reduced MCGF-2 secretion;   reduced mast cell growth factor-2 secretion


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decreased interleukin-4 secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 1700016L21Rik RIKEN cDNA 1700016L21 gene IAGP MGI PMID:15644449 NCBI chr 1:80,423,649...80,453,377
Ensembl chr 1:80,405,912...80,457,752 		JBrowse link
G Arhgef5 Rho guanine nucleotide exchange factor 5 IAGP MGI PMID:19713215 NCBI chr 6:43,242,578...43,266,250
Ensembl chr 6:43,242,516...43,266,254 		JBrowse link
G B2m beta-2 microglobulin IAGP MGI PMID:9164958 NCBI chr 2:121,978,168...121,983,563
Ensembl chr 2:121,978,167...121,983,564 		JBrowse link
G Batf basic leucine zipper transcription factor, ATF-like IAGP MGI PMID:20421391 NCBI chr12:85,733,494...85,755,861
Ensembl chr12:85,733,443...85,755,861 		JBrowse link
G Bcl6 B cell leukemia/lymphoma 6 IAGP MGI PMID:23980208 NCBI chr16:23,780,058...23,807,602
Ensembl chr16:23,783,802...23,807,602 		JBrowse link
G C3ar1 complement component 3a receptor 1 IAGP MGI PMID:12421977 NCBI chr 6:122,824,099...122,833,116
Ensembl chr 6:122,824,097...122,833,120 		JBrowse link
G Cadm1 cell adhesion molecule 1 IAGP MGI PMID:22084409 NCBI chr 9:47,441,468...47,773,578
Ensembl chr 9:47,441,471...47,769,413 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IAGP MGI PMID:9463410 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccr4 C-C motif chemokine receptor 4 IAGP MGI PMID:12154006 NCBI chr 9:114,319,384...114,334,544
Ensembl chr 9:114,319,384...114,333,984 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 IAGP MGI PMID:18258848 NCBI chr17:8,454,875...8,477,353
Ensembl chr17:8,454,875...8,475,973 		JBrowse link
G Ccrl2 C-C motif chemokine receptor-like 2 IAGP MGI PMID:20606167 NCBI chr 9:110,883,902...110,886,586
Ensembl chr 9:110,883,554...110,886,587 		JBrowse link
G Cd1d1 CD1d1 antigen IAGP MGI PMID:9133426 PMID:12902521 PMID:22393151 NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748 		JBrowse link
G Cd274 CD274 antigen IAGP MGI PMID:16606670 NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495 		JBrowse link
G Cd28 CD28 antigen IAGP MGI PMID:8808683 NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518 		JBrowse link
G Chi3l1 chitinase 3 like 1 IAGP MGI PMID:19414556 NCBI chr 1:134,109,894...134,117,769
Ensembl chr 1:134,109,914...134,117,919 		JBrowse link
G Clnk cytokine-dependent hematopoietic cell linker IAGP MGI PMID:16439675 NCBI chr 5:38,858,951...39,034,201
Ensembl chr 5:38,863,805...39,034,155 		JBrowse link
G Col10a1 collagen, type X, alpha 1 IAGP MGI PMID:22692895 NCBI chr10:34,265,977...34,273,081
Ensembl chr10:34,265,977...34,273,081 		JBrowse link
G Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) IAGP MGI PMID:18178860 NCBI chr15:78,210,000...78,235,201
Ensembl chr15:78,209,952...78,238,047 		JBrowse link
G Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) IAGP MGI PMID:18178860 NCBI chr15:78,166,707...78,189,921
Ensembl chr15:78,166,707...78,189,921 		JBrowse link
G Cxcl16 C-X-C motif chemokine ligand 16 IAGP MGI PMID:18056360 NCBI chr11:70,345,215...70,350,810
Ensembl chr11:70,344,809...70,350,810 		JBrowse link
G Ebi3 Epstein-Barr virus induced gene 3 IAGP MGI PMID:12482940 NCBI chr17:56,259,623...56,264,022
Ensembl chr17:56,259,640...56,264,022 		JBrowse link
G Ehmt2 euchromatic histone lysine N-methyltransferase 2 IAGP MGI PMID:20421388 NCBI chr17:35,117,427...35,133,049
Ensembl chr17:35,117,445...35,133,028 		JBrowse link
G Fbn1 fibrillin 1 IAGP MGI PMID:10486156 NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913 		JBrowse link
G Fpr2 formyl peptide receptor 2 IAGP MGI PMID:20200280 NCBI chr17:18,108,086...18,114,214
Ensembl chr17:18,108,086...18,114,214 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta IAGP MGI PMID:14691480 NCBI chr10:80,765,925...80,768,038
Ensembl chr10:80,765,907...80,768,038 		JBrowse link
G Gata3 GATA binding protein 3 IAGP MGI PMID:17658279 NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845 		JBrowse link
G Gimap5 GTPase, IMAP family member 5 IAGP MGI PMID:20190135 NCBI chr 6:48,723,131...48,731,134
Ensembl chr 6:48,723,131...48,731,144 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 IAGP MGI PMID:12944494 NCBI chr  X:52,076,955...52,110,537
Ensembl chr  X:52,077,014...52,110,536 		JBrowse link
G Icos inducible T cell co-stimulator IAGP MGI PMID:17549732 PMID:19915142 NCBI chr 1:60,999,909...61,039,481
Ensembl chr 1:61,017,086...61,039,479 		JBrowse link
G Icosl icos ligand IAGP MGI PMID:12714510 NCBI chr10:77,904,921...77,915,359
Ensembl chr10:77,905,136...77,919,747 		JBrowse link
G Il13 interleukin 13 IAGP MGI PMID:9768762 PMID:11070175 PMID:11323701 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il13ra2 interleukin 13 receptor, alpha 2 IAGP MGI PMID:12642602 NCBI chr  X:146,166,474...146,214,982
Ensembl chr  X:146,166,472...146,212,188 		JBrowse link
G Il17b interleukin 17B IAGP MGI PMID:25888259 NCBI chr18:61,821,006...61,825,609
Ensembl chr18:61,817,958...61,825,609 		JBrowse link
G Il1b interleukin 1 beta IAGP MGI PMID:11265638 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 IAGP MGI PMID:10727469 NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575 		JBrowse link
G Il20rb interleukin 20 receptor beta IAGP MGI PMID:19124723 NCBI chr 9:100,339,772...100,368,526
Ensembl chr 9:100,339,772...100,368,841 		JBrowse link
G Il21r interleukin 21 receptor IAGP MGI PMID:16778988 PMID:19075398 NCBI chr 7:125,202,424...125,232,742
Ensembl chr 7:125,202,601...125,232,742 		JBrowse link
G Il25 interleukin 25 IAGP MGI PMID:20154671 PMID:25888259 NCBI chr14:55,170,152...55,173,294
Ensembl chr14:55,170,152...55,173,294 		JBrowse link
G Il2rg interleukin 2 receptor, gamma chain IAGP MGI PMID:7697543 NCBI chr  X:100,307,991...100,311,861
Ensembl chr  X:100,307,984...100,311,861 		JBrowse link
G Il4 interleukin 4 IAGP MGI PMID:8384701 PMID:8906833 PMID:10486156 PMID:11163225 PMID:11323701 More... NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il4ra interleukin 4 receptor, alpha IAGP MGI PMID:9380721 NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646 		JBrowse link
G Il6st interleukin 6 signal transducer IAGP MGI PMID:10661409 NCBI chr13:112,600,604...112,643,394
Ensembl chr13:112,600,604...112,646,620 		JBrowse link
G Impdh1 inosine monophosphate dehydrogenase 1 IAGP MGI PMID:12944494 NCBI chr 6:29,200,435...29,216,363
Ensembl chr 6:29,200,433...29,216,363 		JBrowse link
G Itk IL2 inducible T cell kinase IAGP MGI PMID:15345221 NCBI chr11:46,215,975...46,280,342
Ensembl chr11:46,215,977...46,280,342 		JBrowse link
G Klra8 killer cell lectin-like receptor, subfamily A, member 8 IAGP MGI PMID:15784573 NCBI chr 6:130,092,189...130,106,861
Ensembl chr 6:130,092,189...130,106,861 		JBrowse link
G Lyz2 lysozyme 2 IAGP MGI PMID:22393151 NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226 		JBrowse link
G Maf MAF bZIP transcription factor IAGP MGI PMID:10403649 NCBI chr 8:116,429,992...116,433,633
Ensembl chr 8:116,409,681...116,434,533 		JBrowse link
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 IAGP MGI PMID:21983831 NCBI chr17:80,887,942...81,039,118
Ensembl chr17:80,887,941...81,035,914 		JBrowse link
G Mgat5 mannoside acetylglucosaminyltransferase 5 IAGP MGI PMID:15585841 NCBI chr 1:127,132,450...127,413,760
Ensembl chr 1:127,132,752...127,416,073 		JBrowse link
G Mgl2 macrophage galactose N-acetyl-galactosamine specific lectin 2 IAGP MGI PMID:24076051 NCBI chr11:70,020,953...70,028,368
Ensembl chr11:70,021,155...70,028,376 		JBrowse link
G Mir155 microRNA 155 IAGP MGI PMID:17463289 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mir21a microRNA 21a IAGP MGI PMID:21849676 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984 		JBrowse link
G Ms4a4a membrane-spanning 4-domains, subfamily A, member 4A IAGP MGI PMID:32589266 NCBI chr19:11,352,827...11,370,682
Ensembl chr19:11,352,887...11,370,154 		JBrowse link
G Nbr1 NBR1, autophagy cargo receptor IAGP MGI PMID:20808283 NCBI chr11:101,442,933...101,472,777
Ensembl chr11:101,442,975...101,472,777 		JBrowse link
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 IAGP MGI PMID:9462518 NCBI chr18:80,649,418...80,756,286
Ensembl chr18:80,649,420...80,756,286 		JBrowse link
G Nfatc2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 IAGP MGI PMID:12150890 NCBI chr 2:168,318,330...168,443,900
Ensembl chr 2:168,318,330...168,443,577 		JBrowse link
G Nfatc2ip nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein IAGP MGI PMID:20133688 NCBI chr 7:125,982,025...125,995,909
Ensembl chr 7:125,982,026...125,995,909 		JBrowse link
G Nfil3 nuclear factor, interleukin 3, regulated IAGP MGI PMID:20080759 NCBI chr13:53,121,245...53,136,914
Ensembl chr13:53,121,245...53,135,109 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 IAGP MGI PMID:9529315 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Notch1 notch 1 IAGP MGI PMID:17658279 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675 		JBrowse link
G Notch2 notch 2 IAGP MGI PMID:17658279 NCBI chr 3:97,920,854...98,057,683
Ensembl chr 3:97,920,843...98,057,677 		JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 IAGP MGI PMID:18591248 NCBI chr 5:123,153,078...123,168,515
Ensembl chr 5:123,153,137...123,168,519 		JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 IAGP MGI PMID:16606670 NCBI chr19:29,388,319...29,450,327
Ensembl chr19:29,388,319...29,448,561 		JBrowse link
G Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform IAGP MGI PMID:8627154 NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488 		JBrowse link
G Prkcq protein kinase C, theta IAGP MGI PMID:15528385 PMID:16493044 PMID:18155708 NCBI chr 2:11,176,922...11,306,033
Ensembl chr 2:11,176,919...11,306,033 		JBrowse link
G Rad50 RAD50 double strand break repair protein IAGP MGI PMID:15608641 PMID:20483988 PMID:23569250 NCBI chr11:53,540,346...53,598,146
Ensembl chr11:53,540,346...53,598,146 		JBrowse link
G Rag1 recombination activating 1 IAGP MGI PMID:15345221 NCBI chr 2:101,468,597...101,479,877
Ensembl chr 2:101,468,627...101,479,846 		JBrowse link
G Rasal3 RAS protein activator like 3 IAGP MGI PMID:25652366 NCBI chr17:32,609,633...32,622,586
Ensembl chr17:32,609,633...32,622,557 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region IAGP MGI PMID:17658279 NCBI chr 5:53,713,121...53,814,787
Ensembl chr 5:53,623,494...53,814,704 		JBrowse link
G Rftn1 raftlin lipid raft linker 1 IAGP MGI PMID:19414744 NCBI chr17:50,300,287...50,497,525
Ensembl chr17:50,299,285...50,497,702 		JBrowse link
G Rnf128 ring finger protein 128 IAGP MGI PMID:20493730 NCBI chr  X:138,464,089...138,573,894
Ensembl chr  X:138,464,065...138,573,894 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 IAGP MGI PMID:19047684 NCBI chr12:26,492,742...26,506,451
Ensembl chr12:26,492,745...26,506,451 		JBrowse link
G Sash3 SAM and SH3 domain containing 3 IAGP MGI PMID:16227612 NCBI chr  X:47,235,313...47,250,442
Ensembl chr  X:47,235,313...47,250,442 		JBrowse link
G Sbsn suprabasin IAGP MGI PMID:32884021 NCBI chr 7:30,432,099...30,455,559
Ensembl chr 7:30,450,896...30,455,559 		JBrowse link
G Slamf6 SLAM family member 6 IAGP MGI PMID:15879084 NCBI chr 1:171,745,002...171,776,525
Ensembl chr 1:171,745,082...171,780,737 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 IAGP MGI PMID:15721841 NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 IAGP MGI PMID:8624821 PMID:10486156 PMID:12441072 PMID:15721841 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826 		JBrowse link
G Stim2 stromal interaction molecule 2 IAGP MGI PMID:18327260 NCBI chr 5:54,155,865...54,278,399
Ensembl chr 5:54,155,841...54,278,399 		JBrowse link
G Tcra T cell receptor alpha chain IAGP MGI PMID:18155708 NCBI chr14:52,665,424...54,461,655 JBrowse link
G Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 IAGP MGI PMID:20808283 NCBI chr 4:156,098,049...156,101,070
Ensembl chr 4:156,098,300...156,101,069 		JBrowse link
G Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 IAGP MGI PMID:12023342 NCBI chr 4:151,004,612...151,030,561
Ensembl chr 4:150,999,019...151,030,559 		JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 IAGP MGI PMID:9950424 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483 		JBrowse link
G Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 IAGP MGI PMID:12070288 NCBI chr17:57,496,437...57,501,182
Ensembl chr17:57,496,492...57,501,177 		JBrowse link
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 IAGP MGI PMID:10626891 NCBI chr 1:161,223,009...161,245,777
Ensembl chr 1:161,222,980...161,245,981 		JBrowse link
G Vav1 vav 1 oncogene IAGP MGI PMID:11500824 NCBI chr17:57,586,080...57,636,236
Ensembl chr17:57,586,100...57,635,031 		JBrowse link
G Vipr2 vasoactive intestinal peptide receptor 2 IAGP MGI PMID:11698667 NCBI chr12:116,041,040...116,117,842
Ensembl chr12:116,041,346...116,109,881 		JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 IAGP MGI PMID:16914726 NCBI chr 3:100,732,775...100,805,555
Ensembl chr 3:100,732,775...100,804,238 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 16734
    immune system phenotype 5613
      abnormal immune system physiology 3422
        abnormal immune serum protein physiology 1440
          abnormal cytokine secretion 819
            abnormal interleukin secretion 600
              abnormal interleukin-4 secretion 164
                decreased interleukin-4 secretion 89
paths to the root