decreased circulating interleukin-1 beta level - Ontology Report

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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:	decreased circulating interleukin-1 beta level	go back to main search page
Accession:	MP:0008642	browse the term
Definition:	reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane
Synonyms:	exact_synonym:	decreased circulating IL-1 beta level; decreased circulating IL-1b level; decreased circulating Il1b level; decreased circulating catabloin level; reduced circulating IL-1 beta level; reduced circulating IL-1b level; reduced circulating Il1b level; reduced circulating catabloin level

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Strains (1)

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BN/Ka

Brown Norway Katholiek (kininogen or kinin deficient)

MODEL: induced

compared to BN

RGD

Term paths to the root

Path 1
Term	Annotations
mammalian phenotype	5420
immune system phenotype	519
abnormal immune system physiology	384
abnormal immune serum protein physiology	92
abnormal cytokine level	39
abnormal interleukin level	23
abnormal circulating interleukin level	23
abnormal circulating interleukin-1 level	2
decreased circulating interleukin-1 level	1
decreased circulating interleukin-1 beta level	1
Path 2
Term	Annotations
mammalian phenotype	5420
homeostasis/metabolism phenotype	1426
abnormal homeostasis	1327
abnormal protein level	137
abnormal intercellular signaling peptide or protein level	43
abnormal cytokine level	39
abnormal interleukin level	23
abnormal circulating interleukin level	23
decreased circulating interleukin level	7
decreased circulating interleukin-1 level	1
decreased circulating interleukin-1 beta level	1

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