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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal circulating interleukin-1 alpha level
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Accession:MP:0008637 term browser browse the term
Definition:anomaly in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active
Synonyms:exact_synonym: abnormal circulating IL-1a level;   abnormal circulating IL-1alpha level;   abnormal circulating IL1 alpha level;   abnormal circulating IL1a level;   abnormal circulating haematopoietin-1 level;   abnormal circulating hematopoietin-1 level



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decreased circulating interleukin-1 alpha level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 IAGP MGI PMID:7859282 PMID:22002608 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase IAGP MGI PMID:7859282 PMID:9491891 PMID:22002608 NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783
JBrowse link
G Gba1 glucosylceramidase beta 1 IAGP MGI PMID:20962279 NCBI chr 3:89,110,235...89,119,944
Ensembl chr 3:89,110,235...89,116,273
JBrowse link
G Il1a interleukin 1 alpha IAGP MGI PMID:9565638 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1b interleukin 1 beta IAGP MGI PMID:9565638 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il22 interleukin 22 IAGP MGI PMID:22038916 NCBI chr10:118,040,456...118,045,952
Ensembl chr10:118,040,847...118,045,952
JBrowse link
G Mmp25 matrix metallopeptidase 25 IAGP MGI PMID:27259858 NCBI chr17:23,847,289...23,864,006
Ensembl chr17:23,847,285...23,864,251
JBrowse link
G Slc6a14 solute carrier family 6 (neurotransmitter transporter), member 14 IAGP MGI PMID:26173258 NCBI chr  X:21,581,139...21,608,597
Ensembl chr  X:21,581,135...21,608,594
JBrowse link
G Tnf tumor necrosis factor IAGP MGI PMID:9426403 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
increased circulating interleukin-1 alpha level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endonuclease 1 IAGP MGI PMID:16936011 NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596
JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:23293022 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,055,336
JBrowse link
G Il10 interleukin 10 IAGP MGI PMID:19941312 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il10ra interleukin 10 receptor, alpha IAGP MGI PMID:19941312 NCBI chr 9:45,165,135...45,180,447
Ensembl chr 9:45,165,135...45,180,447
JBrowse link
G Il1r2 interleukin 1 receptor, type II IAGP MGI PMID:38329807 NCBI chr 1:40,123,872...40,164,390
Ensembl chr 1:40,113,239...40,164,391
JBrowse link
G Itln1 intelectin 1 (galactofuranose binding) IAGP MGI PMID:29619269 NCBI chr 1:171,345,691...171,362,893
Ensembl chr 1:171,345,690...171,362,862
JBrowse link
G Lyz2 lysozyme 2 IAGP MGI PMID:19941312 NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha IAGP MGI PMID:20696914 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Wasl WASP like actin nucleation promoting factor IAGP MGI PMID:28779153 NCBI chr 6:24,613,809...24,665,185
Ensembl chr 6:24,613,804...24,665,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 17090
    immune system phenotype 5778
      abnormal immune system physiology 3513
        abnormal immune serum protein physiology 1487
          abnormal cytokine level 610
            abnormal interleukin level 403
              abnormal circulating interleukin level 347
                abnormal circulating interleukin-1 level 94
                  abnormal circulating interleukin-1 alpha level 18
                    decreased circulating interleukin-1 alpha level 9
                    increased circulating interleukin-1 alpha level 9
Path 2
Term Annotations click to browse term
  mammalian phenotype 17090
    homeostasis/metabolism phenotype 7931
      abnormal homeostasis 7064
        abnormal protein level 2376
          abnormal intercellular signaling peptide or protein level 625
            abnormal cytokine level 610
              abnormal circulating cytokine level 460
                abnormal circulating interleukin level 347
                  abnormal circulating interleukin-1 level 94
                    abnormal circulating interleukin-1 alpha level 18
                      decreased circulating interleukin-1 alpha level 9
                      increased circulating interleukin-1 alpha level 9
paths to the root