decreased circulating interleukin-12 level - Ontology Report

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Term:	decreased circulating interleukin-12 level	go back to main search page
Accession:	MP:0008618	browse the term
Definition:	reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells
Comment:	Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa (IL-12b) and 35 kDa (IL-12a) subunits. The 40 kDa subunit (IL-12b) also is a component of interleukin-23 together with the IL-23a ( 19kDa) chain.
Synonyms:	exact_synonym:	decreased circulating IL-12 level; decreased circulating IL-12 p70 level; decreased circulating IL12 level; decreased circulating cytotoxic lymphocyte maturation factor level; decreased circulating interleukin-12 p70 level; decreased circulating natural killer cell stimulatory factor level; reduced circulating IL-12 level; reduced circulating IL-12 p70 level; reduced circulating IL12 level; reduced circulating cytotoxic lymphocyte maturation factor level; reduced circulating interleukin-12 p70 level; reduced circulating natural killer cell stimulatory factor level

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Term paths to the root

Path 1
Term	Annotations
mammalian phenotype	5417
immune system phenotype	498
abnormal immune system physiology	384
abnormal immune serum protein physiology	92
abnormal cytokine level	39
abnormal interleukin level	23
abnormal circulating interleukin level	23
abnormal circulating interleukin-12 level	0
decreased circulating interleukin-12 level	0
decreased circulating interleukin-12a level	0
Path 2
Term	Annotations
mammalian phenotype	5417
homeostasis/metabolism phenotype	1423
abnormal homeostasis	1324
abnormal protein level	137
abnormal intercellular signaling peptide or protein level	43
abnormal cytokine level	39
abnormal circulating cytokine level	29
abnormal circulating interleukin level	23
abnormal circulating interleukin-12 level	0
decreased circulating interleukin-12 level	0
decreased circulating interleukin-12a level	0

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