increased circulating interleukin-12 level - Ontology Report

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Term:	increased circulating interleukin-12 level	go back to main search page
Accession:	MP:0008617	browse the term
Definition:	increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells
Comment:	Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa (IL-12b) and 35 kDa (IL-12a) subunits. The 40 kDa subunit (IL-12b) also is a component of interleukin-23 together with the IL-23a ( 19kDa) chain.
Synonyms:	exact_synonym:	increased circulating IL-12 level; increased circulating IL-12 p70 level; increased circulating IL12 level; increased circulating cytotoxic lymphocyte maturation factor level; increased circulating interleukin-12 p70 level; increased circulating natural killer cell stimulatory factor level

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Term paths to the root

Path 1
Term	Annotations
mammalian phenotype	5417
immune system phenotype	498
abnormal immune system physiology	384
abnormal immune serum protein physiology	92
abnormal cytokine level	39
abnormal interleukin level	23
abnormal circulating interleukin level	23
abnormal circulating interleukin-12 level	0
increased circulating interleukin-12 level	0
increased circulating interleukin-12a level	0
Path 2
Term	Annotations
mammalian phenotype	5417
homeostasis/metabolism phenotype	1423
abnormal homeostasis	1324
abnormal protein level	137
abnormal intercellular signaling peptide or protein level	43
abnormal cytokine level	39
abnormal circulating cytokine level	29
abnormal circulating interleukin level	23
abnormal circulating interleukin-12 level	0
increased circulating interleukin-12 level	0
increased circulating interleukin-12a level	0

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