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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:decreased circulating interleukin-1 level
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Accession:MP:0008592 term browser browse the term
Definition:reduction in the amount in the blood of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens
Synonyms:exact_synonym: decreased circulating IL-1 level;   decreased circulating T helper factor level;   decreased circulating epidermal cell derived thymocyte-activating factor level;   decreased circulating interleukin I level;   decreased circulating lymphocyte-activating factor level;   decreased circulating macrophage cell factor level;   reduced circulating IL-1 level;   reduced circulating T helper factor level;   reduced circulating epidermal cell derived thymocyte-activating factor level;   reduced circulating interleukin I level;   reduced circulating lymphocyte-activating factor level;   reduced circulating macrophage cell factor level


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decreased circulating interleukin-1 level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1rn interleukin 1 receptor antagonist IAGP MGI PMID:8855299 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 IAGP MGI PMID:11923871 NCBI chr15:94,441,495...94,466,198
Ensembl chr15:94,441,524...94,479,696 		JBrowse link
decreased circulating interleukin-1 alpha level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 IAGP MGI PMID:7859282 PMID:22002608 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase IAGP MGI PMID:7859282 PMID:9491891 PMID:22002608 NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783 		JBrowse link
G Gba1 glucosylceramidase beta 1 IAGP MGI PMID:20962279 NCBI chr 3:89,110,235...89,119,944
Ensembl chr 3:89,110,235...89,116,273 		JBrowse link
G Il1a interleukin 1 alpha IAGP MGI PMID:9565638 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta IAGP MGI PMID:9565638 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il22 interleukin 22 IAGP MGI PMID:22038916 NCBI chr10:118,040,456...118,045,952
Ensembl chr10:118,040,847...118,045,952 		JBrowse link
G Mmp25 matrix metallopeptidase 25 IAGP MGI PMID:27259858 NCBI chr17:23,847,289...23,864,006
Ensembl chr17:23,847,285...23,864,251 		JBrowse link
G Slc6a14 solute carrier family 6 (neurotransmitter transporter), member 14 IAGP MGI PMID:26173258 NCBI chr  X:21,581,139...21,608,597
Ensembl chr  X:21,581,135...21,608,594 		JBrowse link
G Tnf tumor necrosis factor IAGP MGI PMID:9426403 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
decreased circulating interleukin-1 beta level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 IAGP MGI PMID:7859282 PMID:22002608 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase IAGP MGI PMID:7859282 PMID:9491891 PMID:22002608 NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783 		JBrowse link
G Ccdc92 coiled-coil domain containing 92 IAGP MGI PMID:36594018 NCBI chr 5:124,911,482...124,939,261
Ensembl chr 5:124,911,482...124,939,488 		JBrowse link
G F3 coagulation factor III IAGP MGI PMID:15215187 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G Gba1 glucosylceramidase beta 1 IAGP MGI PMID:20962279 NCBI chr 3:89,110,235...89,119,944
Ensembl chr 3:89,110,235...89,116,273 		JBrowse link
G Gbp5 guanylate binding protein 5 IAGP MGI PMID:22461501 NCBI chr 3:142,202,695...142,228,105
Ensembl chr 3:142,199,739...142,228,105 		JBrowse link
G Hectd3 HECT domain E3 ubiquitin protein ligase 3 IAGP MGI PMID:29920190 NCBI chr 4:116,852,491...116,862,474
Ensembl chr 4:116,852,514...116,862,474 		JBrowse link
G Ifi204 interferon activated gene 204 IAGP MGI PMID:29472103 NCBI chr 1:173,574,859...173,594,606
Ensembl chr 1:173,574,859...173,594,509 		JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 IAGP MGI PMID:24014876 NCBI chr19:34,527,961...34,553,934
Ensembl chr19:34,528,094...34,553,819 		JBrowse link
G Il1a interleukin 1 alpha IAGP MGI PMID:9565638 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta IAGP MGI PMID:7621081 PMID:9565638 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6ra interleukin 6 receptor, alpha IAGP MGI PMID:22467660 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503 		JBrowse link
G Jmjd8 jumonji domain containing 8 IAGP MGI PMID:34957483 NCBI chr17:26,048,017...26,050,817
Ensembl chr17:26,047,841...26,050,817 		JBrowse link
G Lacc1 laccase domain containing 1 IAGP MGI PMID:27478939 NCBI chr14:77,261,640...77,274,344
Ensembl chr14:77,261,640...77,274,344 		JBrowse link
G Lyz2 lysozyme 2 IAGP MGI PMID:22467660 NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226 		JBrowse link
G Mtfmt mitochondrial methionyl-tRNA formyltransferase IAGP MGI PMID:36983072 NCBI chr 9:65,343,064...65,360,336
Ensembl chr 9:65,343,064...65,360,336 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 IAGP MGI PMID:12101242 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta IAGP MGI PMID:20740013 NCBI chr 7:28,457,676...28,466,069
Ensembl chr 7:28,457,676...28,466,937 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 IAGP MGI PMID:16546100 PMID:22002608 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 IAGP MGI PMID:15489954 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Peli2 pellino 2 IAGP MGI PMID:29674674 NCBI chr14:48,358,096...48,519,035
Ensembl chr14:48,358,280...48,519,032 		JBrowse link
G Pilrb1 paired immunoglobin-like type 2 receptor beta 1 IAGP MGI PMID:20065029 NCBI chr 5:137,850,403...137,856,687
Ensembl chr 5:137,850,409...137,856,368 		JBrowse link
G Prkce protein kinase C, epsilon IAGP MGI PMID:11696589 NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347 		JBrowse link
G Pycard PYD and CARD domain containing IAGP MGI PMID:16546100 PMID:22002608 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039 		JBrowse link
G Slc15a4 solute carrier family 15, member 4 IAGP MGI PMID:21277849 NCBI chr 5:127,668,795...127,710,356
Ensembl chr 5:127,672,728...127,709,961 		JBrowse link
G Smg1 SMG1 nonsense mediated mRNA decay associated PI3K related kinase IAGP MGI PMID:23277562 NCBI chr 7:117,730,531...117,843,026
Ensembl chr 7:117,730,531...117,842,893 		JBrowse link
G Tlr2 toll-like receptor 2 IAGP MGI PMID:16980352 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tnf tumor necrosis factor IAGP MGI PMID:9426403 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a IAGP MGI PMID:20457915 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 17065
    immune system phenotype 5763
      abnormal immune system physiology 3496
        abnormal immune serum protein physiology 1479
          abnormal cytokine level 606
            abnormal interleukin level 401
              abnormal circulating interleukin level 345
                abnormal circulating interleukin-1 level 94
                  decreased circulating interleukin-1 level 34
                    decreased circulating interleukin-1 alpha level 9
                    decreased circulating interleukin-1 beta level 29
Path 2
Term Annotations click to browse term
  mammalian phenotype 17065
    homeostasis/metabolism phenotype 7909
      abnormal homeostasis 7051
        abnormal protein level 2371
          abnormal intercellular signaling peptide or protein level 621
            abnormal cytokine level 606
              abnormal circulating cytokine level 457
                abnormal circulating interleukin level 345
                  abnormal circulating interleukin-1 level 94
                    decreased circulating interleukin-1 level 34
                      decreased circulating interleukin-1 alpha level 9
                      decreased circulating interleukin-1 beta level 29
paths to the root