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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:decreased circulating tumor necrosis factor level
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Accession:MP:0008554 term browser browse the term
Definition:reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
Synonyms:exact_synonym: decreased circulating TNF level;   decreased circulating TNFA level;   decreased circulating cachectin level;   decreased circulating tumor necrosis factor alpha level;   decreased circulating tumour necrosis factor alpha level;   decreased circulating tumour necrosis factor level;   reduced circulating TNF level;   reduced circulating TNFA level;   reduced circulating cachectin level;   reduced circulating tumor necrosis factor alpha level;   reduced circulating tumor necrosis factor level;   reduced circulating tumour necrosis factor alpha level;   reduced circulating tumour necrosis factor level


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decreased circulating tumor necrosis factor level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1rl2 interleukin 1 receptor-like 2 IMP compared to Wild Type in cardiopulmonary bypass model RGD PMID:32048631 RGD:126925167 NCBI chr 9:42,591,658...42,639,351
Ensembl chr 9:42,591,934...42,636,667 		JBrowse link
G Il1rl2tm1(Myh6-cre)Mhzh interleukin 1 receptor-like 2; tm1 (Myh6-cre), Mhzh IMP compared to Wild Type in cardiopulmonary bypass model RGD PMID:32048631 RGD:126925167
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5417
    homeostasis/metabolism phenotype 1423
      abnormal homeostasis 1324
        abnormal protein level 137
          abnormal circulating protein level 109
            decreased circulating protein level 50
              decreased circulating cytokine level 10
                decreased circulating tumor necrosis factor level 3
Path 2
Term Annotations click to browse term
  mammalian phenotype 5417
    homeostasis/metabolism phenotype 1423
      abnormal homeostasis 1324
        abnormal protein level 137
          abnormal intercellular signaling peptide or protein level 43
            abnormal cytokine level 39
              abnormal circulating cytokine level 29
                abnormal circulating tumor necrosis factor level 12
                  decreased circulating tumor necrosis factor level 3
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