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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased circulating tumor necrosis factor level
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Accession:MP:0008553 term browser browse the term
Definition:greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
Synonyms:exact_synonym: increased circulating TNFA level;   increased circulating cachectin level;   increased circulating tumor necrosis factor alpha level;   increased circulating tumour necrosis factor alpha level;   increased circulating tumour necrosis factor level
 narrow_synonym: Abnormality of serum cytokine level
 related_synonym: increased circulating TNF level
 xref: HP:0011112


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Path 1
Term Annotations click to browse term
  mammalian phenotype 8
    homeostasis/metabolism phenotype 0
      abnormal homeostasis 0
        abnormal protein level 0
          abnormal circulating protein level 0
            increased circulating protein level 0
              increased circulating cytokine level 0
                increased circulating tumor necrosis factor level 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 8
    homeostasis/metabolism phenotype 0
      abnormal homeostasis 0
        abnormal protein level 0
          abnormal intercellular signaling peptide or protein level 0
            abnormal cytokine level 0
              abnormal circulating cytokine level 0
                abnormal circulating tumor necrosis factor level 0
                  increased circulating tumor necrosis factor level 0
paths to the root