decreased Langerhans cell number - Ontology Report

MAMMALIAN PHENOTYPE - ANNOTATIONS	{{ watchLinkText }}
The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:	decreased Langerhans cell number	go back to main search page
Accession:	MP:0008119	browse the term
Definition:	reduction in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus
Synonyms:	exact_synonym:	decreased number of Langerhans cells; reduced Langerhans cell number; reduced number of Langerhans cells

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Rat (3) Mouse (13) Human (0) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (2) Strains (1)

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Csf1r

colony stimulating factor 1 receptor

RGD

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

colony stimulating factor 1 receptor; target mutant, Tset

RGD

Term paths to the root

Path 1
Term	Annotations
mammalian phenotype	5402
hematopoietic system phenotype	250
abnormal hematopoietic system morphology/development	230
abnormal hematopoietic cell morphology	186
abnormal hematopoietic cell number	145
decreased hematopoietic cell number	96
decreased dendritic cell number	3
decreased myeloid dendritic cell number	3
decreased Langerhans cell number	3
absent Langerhans cell	0
Path 2
Term	Annotations
mammalian phenotype	5402
hematopoietic system phenotype	250
abnormal hematopoietic system morphology/development	230
abnormal hematopoietic cell morphology	186
abnormal leukocyte morphology	154
abnormal myeloid leukocyte morphology	70
abnormal phagocyte morphology	47
abnormal mononuclear phagocyte morphology	42
abnormal myeloid dendritic cell morphology	3
abnormal myeloid dendritic cell number	3
decreased myeloid dendritic cell number	3
decreased Langerhans cell number	3
absent Langerhans cell	0

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