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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased CD4-positive, alpha-beta T cell number
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Accession:MP:0008074 term browser browse the term
Definition:greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production
Comment:Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625). Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624). T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
Synonyms:exact_synonym: increased CD4+ T cell number;   increased CD4-positive T cell number


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increased CD4-positive, alpha-beta T cell number term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S LEW/Crl Lewis induces IAGP compared to mAb OX8,341 treated and CB8KO rat RGD PMID:23664330 RGD:38508908
S SHRSP.SHR-(rs197197017 -rs198445122)/Utx IAGP compared to SHR/Utx kidney RGD PMID:32075490 RGD:150429819
S SHRSP/BbbUtx IAGP compared to SHR/Utx, SHRSP.SHR-(rs197197017-rs198445122)/Utx kidney RGD PMID:32075490 RGD:150429819
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S BBDP.ACI-(D2Mit8-D2Arb16)(D2Rat354-D2Rat69)/Sunn IAGP compared to BBDP/WorSunn RGD PMID:24920533 RGD:10043114 NCBI chr 2:143,657,411...190,602,963
NCBI chr 2:191,987,426...191,987,650 		JBrowse link
increased T-helper 2 cell number term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S BB.SHR-(D6Rat184-D6Rat3)/K IAGP compared to BB/OK RGD PMID:11327715 RGD:619685 NCBI chr 6:116,506,292...138,922,889 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5417
    immune system phenotype 498
      abnormal immune system morphology 190
        abnormal immune system cell morphology 150
          abnormal leukocyte morphology 150
            abnormal leukocyte cell number 136
              abnormal lymphocyte cell number 93
                abnormal T cell number 63
                  abnormal alpha-beta T cell number 19
                    abnormal CD4-positive, alpha-beta T cell number 13
                      increased CD4-positive, alpha-beta T cell number 5
                        increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 1
                        increased CD4-positive, alpha-beta memory T cell number + 0
                        increased KLRG1+ CD4 alpha-beta T cell number 0
                        increased T follicular helper cell number 0
                        increased T-helper 1 cell number 0
                        increased T-helper 17 cell number 0
                        increased T-helper 2 cell number 1
Path 2
Term Annotations click to browse term
  mammalian phenotype 5417
    immune system phenotype 498
      abnormal immune system morphology 190
        abnormal immune system cell morphology 150
          abnormal leukocyte morphology 150
            abnormal mononuclear cell morphology 125
              abnormal lymphocyte morphology 97
                abnormal T cell morphology 67
                  abnormal effector T cell morphology 21
                    abnormal CD4-positive, alpha beta T cell morphology 15
                      abnormal CD4-positive, alpha-beta T cell number 13
                        increased CD4-positive, alpha-beta T cell number 5
                          increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 1
                          increased CD4-positive, alpha-beta memory T cell number + 0
                          increased KLRG1+ CD4 alpha-beta T cell number 0
                          increased T follicular helper cell number 0
                          increased T-helper 1 cell number 0
                          increased T-helper 17 cell number 0
                          increased T-helper 2 cell number 1
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