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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal CD4-positive, alpha-beta T cell number
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Accession:MP:0008073 term browser browse the term
Definition:anomaly in the number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production
Comment:Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625). Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624). T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
Synonyms:exact_synonym: abnormal CD4+ T cell number;   abnormal CD4-positive T cell number


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decreased CD4-positive, alpha-beta T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2rg interleukin 2 receptor subunit gamma IMP RGD PMID:29688994 RGD:13628403 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Il2rgem1Ang interleukin 2 receptor subunit gamma;TALEN induced mutant1, Ang IMP RGD PMID:29688994 RGD:13628403
G Rag1 recombination activating 1 IMP RGD PMID:29688994 RGD:13628403 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon IMP RGD PMID:29688994 RGD:13628403
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5417
    hematopoietic system phenotype 246
      abnormal hematopoietic system morphology/development 226
        abnormal hematopoietic cell morphology 182
          abnormal hematopoietic cell number 143
            abnormal leukocyte cell number 136
              abnormal lymphocyte cell number 93
                abnormal T cell number 63
                  abnormal alpha-beta T cell number 19
                    abnormal CD4-positive, alpha-beta T cell number 13
                      abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 3
                      abnormal CD4-positive, alpha-beta memory T cell number + 0
                      abnormal KLRG1+ CD4 alpha-beta T cell number + 0
                      abnormal T follicular helper cell number + 0
                      abnormal T-helper 1 cell number + 0
                      abnormal T-helper 17 cell number + 0
                      abnormal T-helper 2 cell number + 1
                      decreased CD4-positive, alpha-beta T cell number + 8
                      increased CD4-positive, alpha-beta T cell number + 5
Path 2
Term Annotations click to browse term
  mammalian phenotype 5417
    immune system phenotype 498
      abnormal immune system morphology 190
        abnormal immune system cell morphology 150
          abnormal leukocyte morphology 150
            abnormal mononuclear cell morphology 125
              abnormal lymphocyte morphology 97
                abnormal T cell morphology 67
                  abnormal alpha-beta T cell morphology 32
                    abnormal alpha-beta T cell number 19
                      abnormal CD4-positive, alpha-beta T cell number 13
                        abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 3
                        abnormal CD4-positive, alpha-beta memory T cell number + 0
                        abnormal KLRG1+ CD4 alpha-beta T cell number + 0
                        abnormal T follicular helper cell number + 0
                        abnormal T-helper 1 cell number + 0
                        abnormal T-helper 17 cell number + 0
                        abnormal T-helper 2 cell number + 1
                        decreased CD4-positive, alpha-beta T cell number + 8
                        increased CD4-positive, alpha-beta T cell number + 5
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