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ONTOLOGY REPORT - ANNOTATIONS


Term:increased circulating leptin level
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Accession:MP:0005669 term browser browse the term
Definition:greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance
Synonyms:exact_synonym: hyperleptinaemia
 narrow_synonym: hyperleptinemia


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increased circulating leptin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G a nonagouti JBrowse link 2 154,950,599 155,051,012 RGD:5509061
G Adipor1 adiponectin receptor 1 JBrowse link 1 134,415,378 134,433,351 RGD:5509061
G Adra1b adrenergic receptor, alpha 1b JBrowse link 11 43,774,605 43,901,250 RGD:5509061
G Adrb1 adrenergic receptor, beta 1 JBrowse link 19 56,722,117 56,725,150 RGD:5509061
G Adrb3 adrenergic receptor, beta 3 JBrowse link 8 27,225,776 27,230,845 RGD:5509061
G Akr1b7 aldo-keto reductase family 1, member B7 JBrowse link 6 34,412,362 34,423,137 RGD:5509061
G Alms1 ALMS1, centrosome and basal body associated JBrowse link 6 85,587,498 85,726,611 RGD:5509061
G Alox5 arachidonate 5-lipoxygenase JBrowse link 6 116,410,071 116,461,178 RGD:5509061
G Angptl6 angiopoietin-like 6 JBrowse link 9 20,873,808 20,879,822 RGD:5509061
G Ankrd26 ankyrin repeat domain 26 JBrowse link 6 118,501,300 118,562,280 RGD:5509061
G Apmap adipocyte plasma membrane associated protein JBrowse link 2 150,583,080 150,608,567 RGD:5509061
G Apoc3 apolipoprotein C-III JBrowse link 9 46,233,050 46,235,636 RGD:5509061
G Apoe apolipoprotein E JBrowse link 7 19,696,244 19,701,310 RGD:5509061
G Ar androgen receptor JBrowse link X 98,148,757 98,323,218 RGD:5509061
G Bbs1 Bardet-Biedl syndrome 1 (human) JBrowse link 19 4,886,878 4,906,653 RGD:5509061
G Bbs10 Bardet-Biedl syndrome 10 (human) JBrowse link 10 111,298,679 111,301,736 RGD:5509061
G Bbs12 Bardet-Biedl syndrome 12 (human) JBrowse link 3 37,312,547 37,321,450 RGD:5509061
G Bbs4 Bardet-Biedl syndrome 4 (human) JBrowse link 9 59,321,966 59,353,508 RGD:5509061
G Bcl2 B cell leukemia/lymphoma 2 JBrowse link 1 106,538,176 106,714,290 RGD:5509061
G Bcl6 B cell leukemia/lymphoma 6 JBrowse link 16 23,965,050 23,988,866 RGD:5509061
G Bdnf brain derived neurotrophic factor JBrowse link 2 109,674,700 109,727,043 RGD:5509061
G Brd2 bromodomain containing 2 JBrowse link 17 34,112,019 34,122,814 RGD:5509061
G Brs3 bombesin-like receptor 3 JBrowse link X 57,043,074 57,048,758 RGD:5509061
G C1qtnf9 C1q and tumor necrosis factor related protein 9 JBrowse link 14 60,768,134 60,780,869 RGD:5509061
G Capn10 calpain 10 JBrowse link 1 92,934,408 92,947,948 RGD:5509061
G Ccdc80 coiled-coil domain containing 80 JBrowse link 16 45,093,407 45,127,924 RGD:5509061
G Ccl2 chemokine (C-C motif) ligand 2 JBrowse link 11 82,035,577 82,037,452 RGD:5509061
G Ccr2 chemokine (C-C motif) receptor 2 JBrowse link 9 124,101,918 124,109,140 RGD:5509061
G Cd36 CD36 molecule JBrowse link 5 17,781,690 17,888,959 RGD:5509061
G Cdkal1 CDK5 regulatory subunit associated protein 1-like 1 JBrowse link 13 29,191,746 29,855,683 RGD:5509061
G Ceacam2 carcinoembryonic antigen-related cell adhesion molecule 2 JBrowse link 7 25,516,042 25,540,004 RGD:5509061
G Clock circadian locomotor output cycles kaput JBrowse link 5 76,209,868 76,305,603 RGD:5509061
G Cpe carboxypeptidase E JBrowse link 8 64,592,542 64,693,109 RGD:5509061
G Crebbp CREB binding protein JBrowse link 16 4,081,334 4,213,957 RGD:5509061
G Crh corticotropin releasing hormone JBrowse link 3 19,693,401 19,695,396 RGD:5509061
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) JBrowse link 11 54,247,270 54,249,899 RGD:5509061
G Ctf1 cardiotrophin 1 JBrowse link 7 127,712,676 127,718,188 RGD:5509061
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 9 54,165,937 54,268,164 RGD:5509061
G Drd3 dopamine receptor D3 JBrowse link 16 43,754,015 43,825,982 RGD:5509061
G Esr1 estrogen receptor 1 (alpha) JBrowse link 10 4,611,989 5,005,633 RGD:5509061
G Esr2 estrogen receptor 2 (beta) JBrowse link 12 76,120,419 76,177,259 RGD:5509061
G Fabp2 fatty acid binding protein 2, intestinal JBrowse link 3 122,895,072 122,899,506 RGD:5509061
G Ffar4 free fatty acid receptor 4 JBrowse link 19 38,097,079 38,114,263 RGD:5509061
G Fgf21 fibroblast growth factor 21 JBrowse link 7 45,613,890 45,615,490 RGD:5509061
G Fto fat mass and obesity associated JBrowse link 8 91,313,367 91,668,433 RGD:5509061
G Ghr growth hormone receptor JBrowse link 15 3,317,755 3,583,352 RGD:5509061
G Ghrhr growth hormone releasing hormone receptor JBrowse link 6 55,376,295 55,388,530 RGD:5509061
G Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus JBrowse link 2 174,284,320 174,346,744 RGD:5509061
G Gpr26 G protein-coupled receptor 26 JBrowse link 7 131,966,162 131,985,633 RGD:5509061
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano JBrowse link 6 113,067,428 113,077,244 RGD:5509061
G Gucy2c guanylate cyclase 2c JBrowse link 6 136,697,284 136,781,742 RGD:5509061
G Hdc histidine decarboxylase JBrowse link 2 126,593,659 126,624,025 RGD:5509061
G Helz2 helicase with zinc finger 2, transcriptional coactivator JBrowse link 2 181,227,615 181,242,058 RGD:5509061
G Hint2 histidine triad nucleotide binding protein 2 JBrowse link 4 43,654,227 43,656,445 RGD:5509061
G Hrh1 histamine receptor H1 JBrowse link 6 114,397,936 114,483,298 RGD:5509061
G Hrh3 histamine receptor H3 JBrowse link 2 180,099,465 180,104,484 RGD:5509061
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C JBrowse link X 146,962,464 147,197,277 RGD:5509061
G Igf1 insulin-like growth factor 1 JBrowse link 10 87,858,265 87,937,047 RGD:5509061
G Il1r1 interleukin 1 receptor, type I JBrowse link 1 40,222,480 40,316,201 RGD:5509061
G Insr insulin receptor JBrowse link 8 3,150,922 3,279,649 RGD:5509061
G Irs2 insulin receptor substrate 2 JBrowse link 8 10,984,681 11,008,929 RGD:5509061
G Irs4 insulin receptor substrate 4 JBrowse link X 141,710,998 141,725,217 RGD:5509061
G Kdm3a lysine (K)-specific demethylase 3A JBrowse link 6 71,588,970 71,632,990 RGD:5509061
G Lep leptin JBrowse link 6 29,060,221 29,073,876 RGD:5509061
G Lepr leptin receptor JBrowse link 4 101,717,137 101,815,352 RGD:5509061
G Lif leukemia inhibitory factor JBrowse link 11 4,257,568 4,272,514 RGD:5509061
G Lipe lipase, hormone sensitive JBrowse link 7 25,379,527 25,398,486 RGD:5509061
G Lnpep leucyl/cystinyl aminopeptidase JBrowse link 17 17,527,723 17,624,489 RGD:5509061
G Mc3r melanocortin 3 receptor JBrowse link 2 172,248,492 172,251,114 RGD:5509061
G Mc4r melanocortin 4 receptor JBrowse link 18 66,857,705 66,860,487 RGD:5509061
G Med13 mediator complex subunit 13 JBrowse link 11 86,267,033 86,357,596 RGD:5509061
G Mkks McKusick-Kaufman syndrome JBrowse link 2 136,873,780 136,891,406 RGD:5509061
G Mrap2 melanocortin 2 receptor accessory protein 2 JBrowse link 9 87,144,236 87,184,051 RGD:5509061
G Ncoa1 nuclear receptor coactivator 1 JBrowse link 12 4,247,362 4,477,206 RGD:5509061
G Ncoa3 nuclear receptor coactivator 3 JBrowse link 2 165,992,637 166,073,242 RGD:5509061
G Neil1 nei endonuclease VIII-like 1 (E. coli) JBrowse link 9 57,142,788 57,148,688 RGD:5509061
G Nmu neuromedin U JBrowse link 5 76,333,495 76,363,777 RGD:5509061
G Nos1 nitric oxide synthase 1, neuronal JBrowse link 5 117,866,839 117,958,840 RGD:5509061
G Nos3 nitric oxide synthase 3, endothelial cell JBrowse link 5 24,364,816 24,384,474 RGD:5509061
G Npbwr1 neuropeptides B/W receptor 1 JBrowse link 1 5,913,707 5,917,398 RGD:5509061
G Npffr2 neuropeptide FF receptor 2 JBrowse link 5 89,526,840 89,583,914 RGD:5509061
G Npy1r neuropeptide Y receptor Y1 JBrowse link 8 66,697,149 66,706,800 RGD:5509061
G Npy5r neuropeptide Y receptor Y5 JBrowse link 8 66,679,965 66,688,094 RGD:5509061
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 JBrowse link 13 58,806,472 59,133,970 RGD:5509061
G Nts neurotensin JBrowse link 10 102,481,756 102,490,418 RGD:5509061
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 JBrowse link 1 131,910,458 131,936,321 RGD:5509061
G Oma1 OMA1 zinc metallopeptidase JBrowse link 4 103,311,875 103,371,869 RGD:5509061
G Osmr oncostatin M receptor JBrowse link 15 6,813,568 6,874,968 RGD:5509061
G Otp orthopedia homeobox JBrowse link 13 94,875,636 94,885,125 RGD:5509061
G Pcsk1 proprotein convertase subtilisin/kexin type 1 JBrowse link 13 75,089,420 75,134,861 RGD:5509061
G Per1 period circadian clock 1 JBrowse link 11 69,095,108 69,109,965 RGD:5509061
G Per2 period circadian clock 2 JBrowse link 1 91,415,977 91,459,351 RGD:5509061
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 3 32,397,065 32,466,112 RGD:5509061
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta JBrowse link 9 99,038,402 99,140,235 RGD:5509061
G Plin1 perilipin 1 JBrowse link 7 79,721,164 79,732,904 RGD:5509061
G Plscr3 phospholipid scramblase 3 JBrowse link 11 69,846,372 69,852,058 RGD:5509061
G Pnpla2 patatin-like phospholipase domain containing 2 JBrowse link 7 141,455,188 141,460,743 RGD:5509061
G Pomc pro-opiomelanocortin-alpha JBrowse link 12 3,954,945 3,960,643 RGD:5509061
G Pparg peroxisome proliferator activated receptor gamma JBrowse link 6 115,360,879 115,490,404 RGD:5509061
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C JBrowse link 19 36,731,731 36,736,604 RGD:5509061
G Prep prolyl endopeptidase JBrowse link 10 45,067,216 45,162,751 RGD:5509061
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit JBrowse link 4 105,029,649 105,109,898 RGD:5509061
G Prkci protein kinase C, iota JBrowse link 3 30,995,742 31,052,740 RGD:5509061
G Prlh prolactin releasing hormone JBrowse link 1 90,951,709 90,954,121 RGD:5509061
G Prlhr prolactin releasing hormone receptor JBrowse link 19 60,465,641 60,468,933 RGD:5509061
G Prlr prolactin receptor JBrowse link 15 10,177,238 10,349,190 RGD:5509061
G Prox1 prospero homeobox 1 JBrowse link 1 190,118,035 190,170,827 RGD:5509061
G Ptcd1 pentatricopeptide repeat domain 1 JBrowse link 5 145,147,378 145,167,104 RGD:5509061
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:5509061
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 2 167,930,750 167,979,385 RGD:5509061
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 5 121,130,533 121,191,397 RGD:5509061
G Pyy peptide YY JBrowse link 11 102,106,676 102,107,832 RGD:5509061
G Rai1 retinoic acid induced 1 JBrowse link 11 60,104,917 60,199,197 RGD:5509061
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 10,064,401 10,182,251 RGD:5509061
G Rsc1a1 regulatory solute carrier protein, family 1, member 1 JBrowse link 4 141,683,563 141,685,716 RGD:5509061
G Sat1 spermidine/spermine N1-acetyl transferase 1 JBrowse link X 155,213,126 155,216,449 RGD:5509061
G Selenom selenoprotein M JBrowse link 11 3,514,684 3,517,351 RGD:5509061
G Serpina12 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 JBrowse link 12 104,028,769 104,044,443 RGD:5509061
G Sim1 single-minded family bHLH transcription factor 1 JBrowse link 10 50,894,698 50,989,156 RGD:5509061
G Snap25 synaptosomal-associated protein 25 JBrowse link 2 136,713,439 136,782,428 RGD:5509061
G Sqstm1 sequestosome 1 JBrowse link 11 50,200,152 50,210,820 RGD:5509061
G Sstr5 somatostatin receptor 5 JBrowse link 17 25,489,875 25,497,288 RGD:5509061
G Stat3 signal transducer and activator of transcription 3 JBrowse link 11 100,886,806 100,939,594 RGD:5509061
G Stat5a signal transducer and activator of transcription 5A JBrowse link 11 100,859,351 100,885,169 RGD:5509061
G Stat5b signal transducer and activator of transcription 5B JBrowse link 11 100,780,731 100,859,004 RGD:5509061
G Steap4 STEAP family member 4 JBrowse link 5 7,960,472 7,982,213 RGD:5509061
G Tbl1xr1 transducin (beta)-like 1X-linked receptor 1 JBrowse link 3 22,076,253 22,216,594 RGD:5509061
G Thra thyroid hormone receptor alpha JBrowse link 11 98,740,776 98,769,006 RGD:5509061
G Tmem163 transmembrane protein 163 JBrowse link 1 127,490,342 127,678,021 RGD:5509061
G Ubb ubiquitin B JBrowse link 11 62,551,171 62,553,213 RGD:5509061
G Wdtc1 WD and tetratricopeptide repeats 1 JBrowse link 4 133,292,466 133,353,469 RGD:5509061
G Zeb1 zinc finger E-box binding homeobox 1 JBrowse link 18 5,591,327 5,775,468 RGD:5509061

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Term Annotations click to browse term
  mammalian phenotype 14671
    homeostasis/metabolism phenotype 6151
      abnormal homeostasis 5366
        abnormal blood homeostasis 3980
          abnormal circulating hormone level 1100
            abnormal circulating leptin level 251
              increased circulating leptin level 140
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.