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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased susceptibility to type II hypersensitivity reaction
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Accession:MP:0005613 term browser browse the term
Definition:greater likelihood or resistance to developing a response caused by an Ag-Ab reaction; antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues; most often involves IgG and IgM; complement activation is usually involved
Comment:Examples of this include: autoimmune diseases: autoimmune hemolytic anemias, antibody-dependent cellular cytotoxicity (ADCC), Goodpasture disease, myasthenia gravis, Graves disease, pemphigus, and pemphigoid.
Synonyms:exact_synonym: decreased resistance to antibody-mediated cellular toxicity;   decreased resistance to cytotoxic type hypersensitivity;   decreased resistance to type II hypersensitivity reaction;   increased susceptibility to antibody-mediated cellular toxicity;   increased susceptibility to cytotoxic type hypersensitivity


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increased susceptibility to type II hypersensitivity reaction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
Q Iresp1 Immunoglobin response QTL1 QTM RGD PMID:10898507 RGD:619646 NCBI chr20:9,039,719...13,461,775 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5374
    immune system phenotype 492
      abnormal immune system physiology 377
        abnormal adaptive immunity 59
          abnormal type II hypersensitivity reaction 1
            increased susceptibility to type II hypersensitivity reaction 1
Path 2
Term Annotations click to browse term
  mammalian phenotype 5374
    immune system phenotype 492
      abnormal immune system physiology 377
        abnormal inflammatory response 228
          abnormal acute inflammation 5
            abnormal type II hypersensitivity reaction 1
              increased susceptibility to type II hypersensitivity reaction 1
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