MAMMALIAN PHENOTYPE - ANNOTATIONS
The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term: liver/biliary system phenotype
Accession: MP:0005370
browse the term
Definition: the observable morphological and physiological characteristics of the mammalian liver, gall bladder, or bile ducts that are manifested through development and lifespan
Synonyms: exact_synonym: hepatobiliary system phenotype
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Plau
plasminogen activator, urokinase
treatment
IMP
RGD
PMID:23018346
RGD:7241553
NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775
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Ccnd1
cyclin D1
IDA
RGD
PMID:12668975
RGD:704417
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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P2ry2
purinergic receptor P2Y2
IMP
RGD
PMID:19155635
RGD:2316657
NCBI chr 1:164,764,119...164,779,578
Ensembl chr 1:155,351,165...155,367,632
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Fmr1
fragile X messenger ribonucleoprotein 1
IMP
compared to wild type
RGD
PMID:35328827
RGD:405100966
NCBI chr X:152,284,857...152,322,686
Ensembl chr X:147,240,301...147,278,050
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Fmr1em1Sage
FMRP translational regulator 1; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
IMP
compared to wild type
RGD
PMID:35328827
RGD:405100966
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Zbtb16
zinc finger and BTB domain containing 16
IMP
compared to wild type SHR/OlaIpcv;
RGD
PMID:28396530
RGD:150340623
NCBI chr 8:57,885,886...58,073,507
Ensembl chr 8:48,994,566...49,177,011
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Zbtb16em1Ipcv
zinc finger and BTB domain containing 16; TALEN induced mutant 1, Ipcv
IMP
compared to wild type SHR/OlaIpcv;
RGD
PMID:28396530
RGD:150340623
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Atp7b
ATPase copper transporting beta
IAGP
compared to LEC/Tj;
RGD
PMID:11509115
RGD:1302456
NCBI chr16:76,654,725...76,726,092
Ensembl chr16:69,951,778...70,023,636
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Atp7bhts
ATPase copper transporting beta; hepatitis
IAGP
compared to LEC/Tj;
RGD
PMID:11509115
RGD:1302456
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Zbtb16
zinc finger and BTB domain containing 16
IMP
compared to wild type SHR/OlaIpcv;
RGD
PMID:28396530
RGD:150340623
NCBI chr 8:57,885,886...58,073,507
Ensembl chr 8:48,994,566...49,177,011
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Zbtb16em1Ipcv
zinc finger and BTB domain containing 16; TALEN induced mutant 1, Ipcv
IMP
compared to wild type SHR/OlaIpcv;
RGD
PMID:28396530
RGD:150340623
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Atp7b
ATPase copper transporting beta
IAGP
RGD
PMID:17303181
RGD:2292672
NCBI chr16:76,654,725...76,726,092
Ensembl chr16:69,951,778...70,023,636
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Atp7bhts
ATPase copper transporting beta; hepatitis
IAGP
RGD
PMID:17303181
RGD:2292672
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Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
IMP
compared to wild type
RGD
PMID:26077568
RGD:13800514
NCBI chr19:50,307,569...50,312,812
Ensembl chr19:33,397,656...33,402,899
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Hsd11b2em1Jmul
hydroxysteroid 11-beta dehydrogenase 2; ZFN induced mutant1, Jmul
IMP
compared to wild type
RGD
PMID:26077568
RGD:13800514
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Pmch
pro-melanin-concentrating hormone
IMP
RGD
PMID:19934402
RGD:150429945
NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250
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Pmchm1Hubr
pro-melanin-concentrating hormone; ENU induced mutant1, Hubr
IMP
RGD
PMID:19934402
RGD:150429945
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Fabp1
fatty acid binding protein 1
IAGP
RGD
PMID:15532708
RGD:1578454
NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:103,191,006...103,194,788
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Abcb1a
ATP binding cassette subfamily B member 1A
IAGP
RGD
PMID:23569176
RGD:8657335
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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Atp7b
ATPase copper transporting beta
IAGP
RGD
PMID:11509115
RGD:1302456
NCBI chr16:76,654,725...76,726,092
Ensembl chr16:69,951,778...70,023,636
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Atp7bhts
ATPase copper transporting beta; hepatitis
IAGP
RGD
PMID:11509115
RGD:1302456
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Apoa4
apolipoprotein A4
induces
IMP
compared to wild type
RGD
PMID:31303888
RGD:150429948
NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:46,539,082...46,541,469
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Apoa4em1Bcgen
apolipoprotein A4; TALEN induced mutant 1, Bcgn
induces
IMP
compared to wild type
RGD
PMID:31303888
RGD:150429948
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Lepr
leptin receptor
IAGP IMP
RGD
PMID:23154293 PMID:26537785
RGD:13432147 , RGD:12911216
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
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Leprem4Lizh
leptin receptor; CRISPR/Cas9 induced mutant 4, Lizh
IMP
RGD
PMID:26537785
RGD:12911216
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Leprfa
leptin receptor; fa mutant
IAGP
RGD
PMID:23154293
RGD:13432147
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Atp7b
ATPase copper transporting beta
IAGP
RGD
PMID:17303181
RGD:2292672
NCBI chr16:76,654,725...76,726,092
Ensembl chr16:69,951,778...70,023,636
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Atp7bhts
ATPase copper transporting beta; hepatitis
IAGP
RGD
PMID:17303181
RGD:2292672
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Ldlr
low density lipoprotein receptor
IMP
RGD
PMID:28469073
RGD:12910100
NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580
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Ldlrem1Sage
low density lipoprotein receptor; ZFN induced mutant 1, Sage
IMP
RGD
PMID:28469073
RGD:12910100
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Atp7b
ATPase copper transporting beta
IAGP
RGD
PMID:17303181
RGD:2292672
NCBI chr16:76,654,725...76,726,092
Ensembl chr16:69,951,778...70,023,636
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Atp7bhts
ATPase copper transporting beta; hepatitis
IAGP
RGD
PMID:17303181
RGD:2292672
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Ldlr
low density lipoprotein receptor
IMP
RGD
PMID:27378433
RGD:12910104
NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580
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Ldlrem1
low density lipoprotein receptor; ZFN induced mutant 1
IMP
RGD
PMID:27378433
RGD:12910104
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Abcc8
ATP binding cassette subfamily C member 8
IMP
compared to wild type
RGD
PMID:30616503
RGD:150573710
NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:96,598,647...96,679,510
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Abcc8em1Cgen
ATP binding cassette subfamily C member 8; TALEN induced mutant 1, Cgen
IMP
compared to wild type
RGD
PMID:30616503
RGD:150573710
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Cp
ceruloplasmin
IMP
RGD
PMID:31560858
RGD:38549582
NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:102,439,624...102,498,075
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Cpem1Ang
ceruloplasmin; CRISPR/Cas9 induced mutant1, Ang
IMP
RGD
PMID:31560858
RGD:38549582
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Atp7b
ATPase copper transporting beta
IAGP
RGD
PMID:17303181
RGD:2292672
NCBI chr16:76,654,725...76,726,092
Ensembl chr16:69,951,778...70,023,636
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Atp7bhts
ATPase copper transporting beta; hepatitis
IAGP
RGD
PMID:17303181
RGD:2292672
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Bscl2
BSCL2 lipid droplet biogenesis associated, seipin
IMP
RGD
PMID:25934999
RGD:11085488
NCBI chr 1:215,160,764...215,172,540
Ensembl chr 1:205,733,872...205,743,421
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Bscl2m1Kyo
BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo
IMP
RGD
PMID:25934999
RGD:11085488
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
induces
IMP
compared to wild type
RGD
PMID:29656108
RGD:150520032
NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794
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Cyp2j4em1Sage
cytochrome P450, family 2, subfamily j, polypeptide 4, ZFN induced mutant 1, Sage
induces
IMP
compared to wild type
RGD
PMID:29656108
RGD:150520032
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Ldlr
low density lipoprotein receptor
IMP
RGD
PMID:28469073
RGD:12910100
NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580
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Ldlrem1Sage
low density lipoprotein receptor; ZFN induced mutant 1, Sage
IMP
RGD
PMID:28469073
RGD:12910100
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Lep
leptin
IMP
DNA:nonsense mutation:cds:
RGD
PMID:23800849
RGD:8549777
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
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Lepm1Kyo
leptin; ENU induced mutant1, Kyo
IMP
RGD
PMID:23800849
RGD:8549777
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Pparg
peroxisome proliferator-activated receptor gamma
IAGP
RGD
PMID:27381370
RGD:127285618
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
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Ppargm1Kyo
peroxisome proliferator-activated receptor gamma; ENU induced mutant 1, Kyo
IAGP
RGD
PMID:27381370
RGD:127285618
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Bscl2
BSCL2 lipid droplet biogenesis associated, seipin
IMP
RGD
PMID:25934999
RGD:11085488
NCBI chr 1:215,160,764...215,172,540
Ensembl chr 1:205,733,872...205,743,421
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Bscl2m1Kyo
BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo
IMP
RGD
PMID:25934999
RGD:11085488
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
IMP
in KO rat
RGD
PMID:30893315
RGD:126908018
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
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Cdkn1bem1Musc
cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 1, Musc
IMP
RGD
PMID:30893315
RGD:126908018
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Cdkn1bem4Musc
cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 4, Musc
IMP
RGD
PMID:30893315
RGD:126908018
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Pparg
peroxisome proliferator-activated receptor gamma
induces
IAGP
RGD
PMID:27381370
RGD:127285618
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
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Ppargm1Kyo
peroxisome proliferator-activated receptor gamma; ENU induced mutant 1, Kyo
induces
IAGP
RGD
PMID:27381370
RGD:127285618
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Lamp2
lysosomal-associated membrane protein 2
IMP
in hemizygote mutant male (LAMP2y/-)
RGD
PMID:28124283
RGD:13703118
NCBI chr X:122,038,734...122,087,745
Ensembl chr X:117,057,606...117,260,522
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Lamp2em1
lysosomal-associated membrane protein 2; TALEN induced mutant1
IMP
RGD
PMID:28124283
RGD:13703118
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Atp7b
ATPase copper transporting beta
IAGP
RGD
PMID:11509115
RGD:1302456
NCBI chr16:76,654,725...76,726,092
Ensembl chr16:69,951,778...70,023,636
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Atp7bhts
ATPase copper transporting beta; hepatitis
IAGP
RGD
PMID:11509115
RGD:1302456
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Ilk
integrin-linked kinase
IDA
carbon tetrachloride-induced
RGD
PMID:16941698
RGD:2302063
NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:160,088,897...160,095,140
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
treatment
IDA IMP
mRNA:altered expression:liver (rat)
RGD
PMID:15980055 PMID:19418582
RGD:1625201 , RGD:15042868
NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:23,846,122...23,942,047
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Smad3
SMAD family member 3
IDA
RGD
PMID:14512875
RGD:2300428
NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960
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Nfe2l2
NFE2 like bZIP transcription factor 2
IMP
RGD
PMID:27071940
RGD:12910550
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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Nfe2l2em1Kyo
nuclear factor, erythroid 2-like 2; zinc finger nuclease induced mutant 1, Kyoto University
IMP
RGD
PMID:27071940
RGD:12910550
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Nfe2l2em2Kyo
nuclear factor, erythroid 2-like 2; zinc finger nuclease induced mutant 2, Kyoto University
IMP
RGD
PMID:27071940
RGD:12910550
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