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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal serotonin level
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Accession:MP:0005322 term browser browse the term
Definition:anomaly in the amount of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity
Synonyms:exact_synonym: abnormal 5-HT level;   abnormal 5-hydroxytryptamine level;   abnormal enteramine level;   abnormal hippophaine level;   abnormal hydroxytryptamine level
 related_synonym: abnormal serotonin concentration


show annotations for term's descendants           Sort by:
abnormal serotonin level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain derived neurotrophic factor IAGP MGI PMID:10611369 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) IAGP MGI PMID:15344919 NCBI chr11:56,902,342...57,221,070
Ensembl chr11:56,902,213...57,221,070 		JBrowse link
G Gtf2ird1 general transcription factor II I repeat domain-containing 1 IAGP MGI PMID:17680805 NCBI chr 5:134,386,515...134,485,628
Ensembl chr 5:134,386,510...134,485,570 		JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A IAGP MGI PMID:11080193 PMID:11483665 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630 		JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 IAGP MGI PMID:14697676 NCBI chr 4:58,435,252...58,554,601
Ensembl chr 4:58,435,255...58,553,898 		JBrowse link
G Lrp5 low density lipoprotein receptor-related protein 5 IAGP MGI PMID:19041748 NCBI chr19:3,634,825...3,736,574
Ensembl chr19:3,634,828...3,736,564 		JBrowse link
G Maged1 MAGE family member D1 IAGP MGI PMID:22457503 NCBI chr  X:93,579,080...93,585,631
Ensembl chr  X:93,579,080...93,585,749 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal IAGP MGI PMID:11158630 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell IAGP MGI PMID:10964974 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 IAGP MGI PMID:17457314 NCBI chr 2:56,996,845...57,014,152
Ensembl chr 2:56,996,842...57,014,015 		JBrowse link
G Pts 6-pyruvoyl-tetrahydropterin synthase IAGP MGI PMID:12734191 NCBI chr 9:50,432,917...50,440,017
Ensembl chr 9:50,432,917...50,440,024 		JBrowse link
G S100a10 S100 calcium binding protein A10 (calpactin) IAGP MGI PMID:16400147 NCBI chr 3:93,462,424...93,471,952
Ensembl chr 3:93,462,387...93,471,950 		JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 IAGP MGI PMID:9427250 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444 		JBrowse link
G Slitrk2 SLIT and NTRK-like family, member 2 IAGP MGI PMID:35789858 NCBI chr  X:65,692,535...65,705,008
Ensembl chr  X:65,692,924...65,704,999 		JBrowse link
G Snap25 synaptosomal-associated protein 25 IAGP MGI PMID:21949876 NCBI chr 2:136,555,359...136,624,348
Ensembl chr 2:136,555,373...136,624,348 		JBrowse link
G Tnc tenascin C IAGP MGI PMID:8660327 NCBI chr 4:63,878,022...63,965,554
Ensembl chr 4:63,878,022...63,965,252 		JBrowse link
G Tph1 tryptophan hydroxylase 1 IAGP MGI PMID:18923670 NCBI chr 7:46,294,065...46,321,961
Ensembl chr 7:46,294,065...46,321,961 		JBrowse link
G Tph2 tryptophan hydroxylase 2 IAGP MGI PMID:15247473 NCBI chr10:114,914,546...115,020,927
Ensembl chr10:114,914,546...115,020,927 		JBrowse link
decreased platelet serotonin level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G a non-agouti IAGP MGI PMID:2369371 PMID:6696991 PMID:12070017 NCBI chr 2:154,792,519...154,892,932
Ensembl chr 2:154,633,322...154,892,932 		JBrowse link
G Ap3b1 adaptor-related protein complex 3, beta 1 subunit IAGP MGI PMID:6696991 NCBI chr13:94,492,332...94,702,838
Ensembl chr13:94,495,468...94,702,825 		JBrowse link
G Ap3d1 adaptor-related protein complex 3, delta 1 subunit IAGP MGI PMID:1912584 NCBI chr10:80,542,790...80,578,137
Ensembl chr10:80,542,790...80,578,098 		JBrowse link
G Bloc1s4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino IAGP MGI PMID:11110696 NCBI chr 5:36,904,718...36,906,023
Ensembl chr 5:36,904,722...36,905,994 		JBrowse link
G Bloc1s5 biogenesis of lysosomal organelles complex-1, subunit 5, muted IAGP MGI PMID:1912584 NCBI chr13:38,786,674...38,821,093
Ensembl chr13:38,776,818...38,819,085 		JBrowse link
G Bloc1s6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin IAGP MGI PMID:6696991 NCBI chr 2:122,580,425...122,591,407
Ensembl chr 2:122,580,423...122,591,395 		JBrowse link
G Dtnbp1 dystrobrevin binding protein 1 IAGP MGI PMID:12923531 NCBI chr13:45,075,552...45,155,614
Ensembl chr13:45,075,551...45,155,623 		JBrowse link
G Hps1 HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 IAGP MGI PMID:2369371 PMID:6696991 NCBI chr19:42,743,629...42,770,013
Ensembl chr19:42,743,544...42,768,417 		JBrowse link
G Hps3 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 IAGP MGI PMID:3408670 NCBI chr 3:20,050,109...20,089,478
Ensembl chr 3:20,050,109...20,089,479 		JBrowse link
G Hps4 HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 IAGP MGI PMID:2369371 PMID:6696991 NCBI chr 5:112,490,849...112,526,290
Ensembl chr 5:112,490,949...112,526,280 		JBrowse link
G Hps5 HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 IAGP MGI PMID:2369371 PMID:6696991 NCBI chr 7:46,409,890...46,445,501
Ensembl chr 7:46,409,890...46,445,488 		JBrowse link
G Hps6 HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 IAGP MGI PMID:2369371 PMID:6696991 NCBI chr19:45,991,917...45,994,612
Ensembl chr19:45,991,947...45,994,612 		JBrowse link
G Lyst lysosomal trafficking regulator IAGP MGI PMID:6696991 NCBI chr13:13,764,896...13,953,388
Ensembl chr13:13,764,982...13,953,388 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family IAGP MGI PMID:10859366 PMID:12070017 PMID:17062724 PMID:17384153 NCBI chr 9:72,952,092...73,004,905
Ensembl chr 9:72,952,136...73,004,911 		JBrowse link
G Rab27b RAB27B, member RAS oncogene family IAGP MGI PMID:17384153 NCBI chr18:70,112,202...70,274,704
Ensembl chr18:70,112,202...70,274,676 		JBrowse link
G Rab32 RAB32, member RAS oncogene family IAGP MGI PMID:31399401 NCBI chr10:10,420,783...10,433,951
Ensembl chr10:10,420,746...10,434,009 		JBrowse link
G Rab38 RAB38, member RAS oncogene family IAGP MGI PMID:31399401 NCBI chr 7:88,079,481...88,140,780
Ensembl chr 7:88,079,481...88,140,780 		JBrowse link
G Rabggta Rab geranylgeranyl transferase, a subunit IAGP MGI PMID:8490171 NCBI chr14:55,953,321...55,959,720
Ensembl chr14:55,952,873...55,959,720 		JBrowse link
G Slc35d3 solute carrier family 35, member D3 IAGP MGI PMID:17062724 NCBI chr10:19,723,662...19,728,195
Ensembl chr10:19,723,662...19,727,205 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 IAGP MGI PMID:8699821 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
decreased serotonin level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrp agouti related neuropeptide IAGP MGI PMID:22419158 NCBI chr 8:106,293,327...106,306,477
Ensembl chr 8:106,293,330...106,364,025 		JBrowse link
G Celf6 CUGBP, Elav-like family member 6 IAGP MGI PMID:23407934 NCBI chr 9:59,485,587...59,516,316
Ensembl chr 9:59,485,200...59,514,575 		JBrowse link
G Crtc1 CREB regulated transcription coactivator 1 IAGP MGI PMID:22592058 NCBI chr 8:70,835,002...70,892,720
Ensembl chr 8:70,835,005...70,892,229 		JBrowse link
G Dbp D site albumin promoter binding protein IAGP MGI PMID:15175240 NCBI chr 7:45,354,658...45,359,579
Ensembl chr 7:45,354,512...45,359,627 		JBrowse link
G Ddc dopa decarboxylase IAGP MGI PMID:23275025 PMID:28973165 NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144 		JBrowse link
G Disc1 disrupted in schizophrenia 1 IAGP MGI PMID:21903668 NCBI chr 8:125,773,928...125,991,882
Ensembl chr 8:125,780,934...125,988,597 		JBrowse link
G En1 engrailed 1 IAGP MGI PMID:12764108 NCBI chr 1:120,530,246...120,535,719
Ensembl chr 1:120,530,147...120,535,721 		JBrowse link
G Esr2 estrogen receptor 2 (beta) IAGP MGI PMID:15642619 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Fev FEV transcription factor, ETS family member IAGP MGI PMID:20818386 NCBI chr 1:74,920,660...74,924,632
Ensembl chr 1:74,920,668...74,924,578 		JBrowse link
G Gata3 GATA binding protein 3 IAGP MGI PMID:20818386 NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845 		JBrowse link
G Gch1 GTP cyclohydrolase 1 IAGP MGI PMID:30742839 NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870 		JBrowse link
G Ghr growth hormone receptor IAGP MGI PMID:31806625 NCBI chr15:3,347,237...3,612,834
Ensembl chr15:3,347,242...3,612,974 		JBrowse link
G Hlf hepatic leukemia factor IAGP MGI PMID:15175240 NCBI chr11:90,227,361...90,281,745
Ensembl chr11:90,227,362...90,281,721 		JBrowse link
G Lmx1b LIM homeobox transcription factor 1 beta IAGP MGI PMID:21246047 NCBI chr 2:33,450,977...33,531,219
Ensembl chr 2:33,450,977...33,530,620 		JBrowse link
G Lrp5 low density lipoprotein receptor-related protein 5 IAGP MGI PMID:19041748 NCBI chr19:3,634,825...3,736,574
Ensembl chr19:3,634,828...3,736,564 		JBrowse link
G Lrtm2 leucine-rich repeats and transmembrane domains 2 IAGP MGI PMID:35615067 NCBI chr 6:119,292,094...119,315,009
Ensembl chr 6:119,292,094...119,307,727 		JBrowse link
G Maged1 MAGE family member D1 IAGP MGI PMID:22457503 NCBI chr  X:93,579,080...93,585,631
Ensembl chr  X:93,579,080...93,585,749 		JBrowse link
G Mchr1 melanin-concentrating hormone receptor 1 IAGP MGI PMID:15988472 NCBI chr15:81,119,700...81,123,165
Ensembl chr15:81,119,700...81,123,165 		JBrowse link
G Mecp2 methyl CpG binding protein 2 IAGP MGI PMID:20633611 NCBI chr  X:73,070,198...73,129,296
Ensembl chr  X:73,070,198...73,129,296 		JBrowse link
G Mitf melanogenesis associated transcription factor IAGP MGI PMID:9949161 NCBI chr 6:97,783,966...97,998,321
Ensembl chr 6:97,784,013...97,998,310 		JBrowse link
G Nenf neuron derived neurotrophic factor IAGP MGI PMID:24058337 NCBI chr 1:191,038,984...191,050,328
Ensembl chr 1:191,038,986...191,050,391 		JBrowse link
G Pah phenylalanine hydroxylase IAGP MGI PMID:12499868 PMID:33790381 NCBI chr10:87,357,657...87,419,999
Ensembl chr10:87,357,657...87,419,998 		JBrowse link
G Prss57 serine protease 57 IAGP MGI PMID:33214666 NCBI chr10:79,617,308...79,630,523
Ensembl chr10:79,617,308...79,626,795 		JBrowse link
G Pts 6-pyruvoyl-tetrahydropterin synthase IAGP MGI PMID:11517215 PMID:16135092 NCBI chr 9:50,432,917...50,440,017
Ensembl chr 9:50,432,917...50,440,024 		JBrowse link
G Rnf180 ring finger protein 180 IAGP MGI PMID:23926250 NCBI chr13:105,267,075...105,431,406
Ensembl chr13:105,266,509...105,431,323 		JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 IAGP MGI PMID:11463816 PMID:19553450 PMID:21814181 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444 		JBrowse link
G Slc25a12 solute carrier family 25 (mitochondrial carrier, Aralar), member 12 IAGP MGI PMID:23216354 NCBI chr 2:71,104,614...71,198,125
Ensembl chr 2:71,101,407...71,198,093 		JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 IAGP MGI PMID:9547354 PMID:10841514 PMID:16380550 PMID:21814181 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166 		JBrowse link
G Spr sepiapterin reductase IAGP MGI PMID:16532389 PMID:18201550 NCBI chr 6:85,110,662...85,114,746
Ensembl chr 6:85,107,158...85,114,748 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A IAGP MGI PMID:31806625 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995 		JBrowse link
G Tef thyrotroph embryonic factor IAGP MGI PMID:15175240 NCBI chr15:81,686,874...81,711,064
Ensembl chr15:81,686,622...81,711,064 		JBrowse link
G Tph1 tryptophan hydroxylase 1 IAGP MGI PMID:14597720 PMID:18923670 PMID:19041748 NCBI chr 7:46,294,065...46,321,961
Ensembl chr 7:46,294,065...46,321,961 		JBrowse link
G Tph2 tryptophan hydroxylase 2 IAGP MGI PMID:18212115 PMID:18923670 PMID:19520831 PMID:20722968 PMID:21441904 More... NCBI chr10:114,914,546...115,020,927
Ensembl chr10:114,914,546...115,020,927 		JBrowse link
G Zfp148 zinc finger protein 148 IAGP MGI PMID:23395646 NCBI chr16:33,201,145...33,324,273
Ensembl chr16:33,201,206...33,324,733 		JBrowse link
increased serotonin level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 7630403G23Rik RIKEN cDNA 7630403G23 gene IAGP MGI PMID:19630976 NCBI chr 9:33,953,667...33,970,315
Ensembl chr 9:33,953,665...33,970,315 		JBrowse link
G Adgrl3 adhesion G protein-coupled receptor L3 IAGP MGI PMID:22575564 NCBI chr 5:81,167,600...81,980,556
Ensembl chr 5:81,167,985...81,972,980 		JBrowse link
G Apba2 amyloid beta precursor protein binding family A member 2 IAGP MGI PMID:19420255 NCBI chr 7:64,151,444...64,403,620
Ensembl chr 7:64,151,454...64,403,626 		JBrowse link
G Arhgef10 Rho guanine nucleotide exchange factor 10 IAGP MGI PMID:29456827 NCBI chr 8:14,956,405...15,051,085
Ensembl chr 8:14,961,663...15,051,085 		JBrowse link
G Cdk5r1 cyclin dependent kinase 5, regulatory subunit 1 IAGP MGI PMID:20832057 NCBI chr11:80,367,849...80,372,010
Ensembl chr11:80,367,849...80,372,010 		JBrowse link
G Cmya5 cardiomyopathy associated 5 IAGP MGI PMID:34037836 NCBI chr13:93,177,221...93,281,278
Ensembl chr13:93,177,221...93,281,232 		JBrowse link
G En2 engrailed 2 IAGP MGI PMID:16935268 NCBI chr 5:28,370,694...28,377,195
Ensembl chr 5:28,370,692...28,377,164 		JBrowse link
G Foxp2 forkhead box P2 IAGP MGI PMID:19490899 NCBI chr 6:14,901,348...15,441,976
Ensembl chr 6:14,901,348...15,441,976 		JBrowse link
G Fyn Fyn proto-oncogene IAGP MGI PMID:11834300 NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377 		JBrowse link
G Gpr88 G-protein coupled receptor 88 IAGP MGI PMID:26188600 NCBI chr 3:116,043,304...116,047,123
Ensembl chr 3:116,043,303...116,047,152 		JBrowse link
G Gpx1 glutathione peroxidase 1 IAGP MGI PMID:24075852 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 IAGP MGI PMID:20178820 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:19630976 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,054,294 		JBrowse link
G Lrp5 low density lipoprotein receptor-related protein 5 IAGP MGI PMID:19041748 NCBI chr19:3,634,825...3,736,574
Ensembl chr19:3,634,828...3,736,564 		JBrowse link
G Maged1 MAGE family member D1 IAGP MGI PMID:22457503 NCBI chr  X:93,579,080...93,585,631
Ensembl chr  X:93,579,080...93,585,749 		JBrowse link
G Maoa monoamine oxidase A IAGP MGI PMID:7792602 PMID:10844034 PMID:15272015 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057 		JBrowse link
G Maob monoamine oxidase B IAGP MGI PMID:15272015 NCBI chr  X:16,575,520...16,683,605
Ensembl chr  X:16,575,521...16,683,605 		JBrowse link
G Mfn2 mitofusin 2 IAGP MGI PMID:22914740 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Mpst mercaptopyruvate sulfurtransferase IAGP MGI PMID:23759691 NCBI chr15:78,290,918...78,298,213
Ensembl chr15:78,290,616...78,298,213 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 IAGP MGI PMID:20016108 NCBI chr 2:56,996,845...57,014,152
Ensembl chr 2:56,996,842...57,014,015 		JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 IAGP MGI PMID:24075852 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase IAGP MGI PMID:24075852 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Slc17a3 solute carrier family 17 (sodium phosphate), member 3 IAGP MGI PMID:38641061 NCBI chr13:24,020,905...24,044,701
Ensembl chr13:24,023,417...24,044,699 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 IAGP MGI PMID:20016108 PMID:22131425 PMID:22914740 PMID:25331903 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 IAGP MGI PMID:22431635 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166 		JBrowse link
G Slc6a8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 IAGP MGI PMID:21249153 NCBI chr  X:72,716,739...72,726,108
Ensembl chr  X:72,716,756...72,726,108 		JBrowse link
G Stx1a syntaxin 1A (brain) IAGP MGI PMID:20576034 NCBI chr 5:135,051,473...135,079,954
Ensembl chr 5:135,052,336...135,079,954 		JBrowse link
G Taar1 trace amine-associated receptor 1 IAGP MGI PMID:22114263 NCBI chr10:23,796,304...23,797,302
Ensembl chr10:23,796,254...23,797,367 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase IAGP MGI PMID:19323847 NCBI chr 3:81,865,719...81,883,035
Ensembl chr 3:81,864,397...81,883,509 		JBrowse link
G Th tyrosine hydroxylase IAGP MGI PMID:12704806 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
G Tnf tumor necrosis factor IAGP MGI PMID:11063830 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Ube3a ubiquitin protein ligase E3A IAGP MGI PMID:22916201 NCBI chr 7:58,871,891...58,960,585
Ensembl chr 7:58,878,498...58,961,284 		JBrowse link
Term paths to the root
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  mammalian phenotype 16962
    homeostasis/metabolism phenotype 7866
      abnormal homeostasis 7015
        abnormal hormone level 1305
          abnormal serotonin level 94
            abnormal platelet serotonin level + 20
            decreased serotonin level + 54
            increased serotonin level + 32
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