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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal regulatory T cell morphology
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Accession:MP:0004941 term browser browse the term
Definition:any structural anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function
Synonyms:exact_synonym: abnormal regulatory T lymphocyte morphology;   abnormal regulatory T-lymphocyte;   abnormal suppressor T cell morphology;   abnormal suppressor T cell morphology/development;   abnormal suppressor T lymphocyte morphology;   suppressor T cell abnormalities
 narrow_synonym: abnormal Treg cell morphology
 alt_id: MP:0002437
 xref: CL:0000815


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increased regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sh2b3 SH2B adaptor protein 3 IMP RGD PMID:25776069 RGD:13442483 NCBI chr12:34,731,934...34,753,617
Ensembl chr12:34,731,911...34,753,616 		JBrowse link
G Sh2b3em1Mcwi SH2B adaptor protein 3; zinc finger nuclease induced mutant 1, Medical College of Wisconsin IMP RGD PMID:25776069 RGD:13442483
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  mammalian phenotype 5420
    hematopoietic system phenotype 250
      abnormal hematopoietic system morphology/development 230
        abnormal hematopoietic cell morphology 186
          abnormal leukocyte morphology 154
            abnormal mononuclear cell morphology 127
              abnormal lymphocyte morphology 99
                abnormal T cell morphology 69
                  abnormal regulatory T cell morphology 7
                    abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology + 3
                    abnormal CD8-positive, alpha-beta regulatory T cell morphology 0
                    abnormal regulatory T cell number + 7
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