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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal class switch recombination
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Accession:MP:0004816 term browser browse the term
Definition:anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions
Synonyms:exact_synonym: abnormal CSR;   abnormal isotype switching


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Path 1
Term Annotations click to browse term
  mammalian phenotype 0
    immune system phenotype 0
      abnormal immune system physiology 0
        abnormal immune cell physiology 0
          abnormal professional antigen presenting cell physiology 0
            abnormal B cell physiology 0
              abnormal class switch recombination 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 0
    hematopoietic system phenotype 0
      abnormal hematopoietic system morphology/development 0
        abnormal hematopoietic cell morphology 0
          abnormal blood cell morphology 0
            abnormal hemopoiesis 0
              abnormal definitive hematopoiesis 0
                abnormal leukopoiesis 0
                  abnormal lymphopoiesis 0
                    abnormal B cell differentiation 0
                      abnormal class switch recombination 0
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