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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:tau protein deposits
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Accession:MP:0004250 term browser browse the term
Definition:formation of self-assembled tangles of paired helical filaments and straight filaments due to hyperphosphorylation of the tau protein; often seen in neuronal tissues of individuals with neurodegenerative disorders
Synonyms:exact_synonym: tau protein tangles


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tau protein deposits term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S BDIV-Myo5a/StcRrrc IAGP in brain stem, mesencephalon, olfactory bulb, frontal cortex; compared to control BD-IV RGD PMID:29217155 RGD:42721980
S SHR-Tg(Thy1-MAPT)318 IMP RGD PMID:16753151 RGD:2290296
S SHR-Tg(Thy1-MAPT)72 IMP RGD PMID:16753151 RGD:2290296
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5402
    nervous system phenotype 369
      abnormal nervous system morphology 215
        nervous system inclusion bodies 10
          tau protein deposits 3
Path 2
Term Annotations click to browse term
  mammalian phenotype 5402
    nervous system phenotype 369
      abnormal nervous system morphology 215
        abnormal brain morphology 139
          brain lesion 16
            tau protein deposits 3
paths to the root